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Q0CMF3 (BGALB_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase B

EC=3.2.1.23
Alternative name(s):
Lactase B
Gene names
Name:lacB
ORF Names:ATEG_05131
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1022 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Sequence caution

The sequence EAU34200.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 10221002Probable beta-galactosidase B
PRO_0000395227

Sites

Active site1961Proton donor Potential
Active site3081Nucleophile Potential
Binding site901Substrate By similarity
Binding site1351Substrate By similarity
Binding site1361Substrate; via amide nitrogen By similarity
Binding site1371Substrate By similarity
Binding site1951Substrate By similarity
Binding site2651Substrate By similarity
Binding site3731Substrate By similarity

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation4111N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation5411N-linked (GlcNAc...) Potential
Glycosylation5541N-linked (GlcNAc...) Potential
Glycosylation6261N-linked (GlcNAc...) Potential
Glycosylation7771N-linked (GlcNAc...) Potential
Glycosylation7901N-linked (GlcNAc...) Potential
Glycosylation8321N-linked (GlcNAc...) Potential
Glycosylation8801N-linked (GlcNAc...) Potential
Glycosylation8811N-linked (GlcNAc...) Potential
Disulfide bond271 ↔ 324 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0CMF3 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: 032C051812784E46

FASTA1,022111,471
        10         20         30         40         50         60 
MARFPQLLFL LLASIGLLSA AQNHSDSEWP LHDNGLSTVV QWDHYSFHVH GQRIFVFSGE 

        70         80         90        100        110        120 
FHYWRIPVPG LWRDILEKIK AAGFTAFAFY SSWGYHAPNN HTVDFSTGAR DITPIYELAK 

       130        140        150        160        170        180 
ELGMYIIVRP GPYVNAEASA GGYPLWVTTG AYGSLRNDDA RYTAAWKPYF AKMSEITSQY 

       190        200        210        220        230        240 
QVTDGHNTFC YQIENEYGQQ WIGDPVDRNP NQTAVAYMEL LEASARENGI VVPLTANDPN 

       250        260        270        280        290        300 
MNTKSWGSDW SHAGGNVDVV GLDSYPSCWT CDVTQCTSTN GEYVPYKVMQ YYDYFQEVQP 

       310        320        330        340        350        360 
TMPGFMPEFQ GGSYNPWAGP EGGCPGDTGV DFANLFYRWN IAQRVTAMSL YMLYGGTNWG 

       370        380        390        400        410        420 
AIAAPVTATS YDYSSPISED RSIGSKYYET KLLALFTRSA TDLTMTDRIG NGTHYTNNPA 

       430        440        450        460        470        480 
VAAYELRNPV TNGAFYVTIH ADSTVGTDES FRLNVNTSAG ALTVPSKGSI RLNGHQSKII 

       490        500        510        520        530        540 
VTDFRFGPSH TLLYSTAEVL THAVMDKKAT LVLWVPTGES GEFAVKGAKS GKVERCPQCS 

       550        560        570        580        590        600 
NATFTRKKDV LVVNFTQAGG MSVLQLNNGV RVVLLDRAAA YKFWAPPLTD DPFAPETDLV 

       610        620        630        640        650        660 
LVQGPYLVRS ASLSGSTLAL RGDSANETAL EVFASKKVHT VTWNGKRIKT SRSSYGSLTA 

       670        680        690        700        710        720 
SLAAPPAVSL PALSSAQWKS QDSLPERLPS YDDSGPAWVD ANHMTTQNPR TPDTLPVLYA 

       730        740        750        760        770        780 
DEYGFHNGIR LWRGSFTDAA SGVYLNVQGG AAFGWSAYLN GHFLGSHLGT ATTSQANKTL 

       790        800        810        820        830        840 
LFPAGTLRKN TTNTILVIHD DTGHDQTTGA LNPRGILAAR LLAPSDSSTA PNFTQWRVAG 

       850        860        870        880        890        900 
TAGGESDLDP VRGVYNEDGL FAERMGWHLP GFDDADWPAN NSTTTRGAQV SLSVTGATVR 

       910        920        930        940        950        960 
FFRAVVPLHL PRGVDASISF MLGTPAGAST AYRAQLFVNG YQYGRFYPHI GNQVVYPVPA 

       970        980        990       1000       1010       1020 
GVLDYDGENT IGVAVWAQSE AGAEMSLDWR VNYVADSSLD AVRVAAEGAL RPGWSEERLQ 


YA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476600 Genomic DNA. Translation: EAU34200.1. Sequence problems.
RefSeqXP_001214309.1. XM_001214309.1.

3D structure databases

ProteinModelPortalQ0CMF3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00004534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4320669.

Phylogenomic databases

eggNOGCOG1874.
HOGENOMHOG000181922.
OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SMARTSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALB_ASPTN
AccessionPrimary (citable) accession number: Q0CMF3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries