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Q0CMF3

- BGALB_ASPTN

UniProt

Q0CMF3 - BGALB_ASPTN

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Protein

Probable beta-galactosidase B

Gene
lacB, ATEG_05131
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Binding sitei136 – 1361Substrate; via amide nitrogen By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei195 – 1951Substrate By similarity
Active sitei196 – 1961Proton donor Reviewed prediction
Binding sitei265 – 2651Substrate By similarity
Active sitei308 – 3081Nucleophile Reviewed prediction
Binding sitei373 – 3731Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:ATEG_05131
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 10221002Probable beta-galactosidase BPRO_0000395227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi271 ↔ 324 By similarity
Glycosylationi411 – 4111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi541 – 5411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi554 – 5541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi626 – 6261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi777 – 7771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi790 – 7901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi832 – 8321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi880 – 8801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi881 – 8811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00004534.

Structurei

3D structure databases

ProteinModelPortaliQ0CMF3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CMF3-1 [UniParc]FASTAAdd to Basket

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MARFPQLLFL LLASIGLLSA AQNHSDSEWP LHDNGLSTVV QWDHYSFHVH     50
GQRIFVFSGE FHYWRIPVPG LWRDILEKIK AAGFTAFAFY SSWGYHAPNN 100
HTVDFSTGAR DITPIYELAK ELGMYIIVRP GPYVNAEASA GGYPLWVTTG 150
AYGSLRNDDA RYTAAWKPYF AKMSEITSQY QVTDGHNTFC YQIENEYGQQ 200
WIGDPVDRNP NQTAVAYMEL LEASARENGI VVPLTANDPN MNTKSWGSDW 250
SHAGGNVDVV GLDSYPSCWT CDVTQCTSTN GEYVPYKVMQ YYDYFQEVQP 300
TMPGFMPEFQ GGSYNPWAGP EGGCPGDTGV DFANLFYRWN IAQRVTAMSL 350
YMLYGGTNWG AIAAPVTATS YDYSSPISED RSIGSKYYET KLLALFTRSA 400
TDLTMTDRIG NGTHYTNNPA VAAYELRNPV TNGAFYVTIH ADSTVGTDES 450
FRLNVNTSAG ALTVPSKGSI RLNGHQSKII VTDFRFGPSH TLLYSTAEVL 500
THAVMDKKAT LVLWVPTGES GEFAVKGAKS GKVERCPQCS NATFTRKKDV 550
LVVNFTQAGG MSVLQLNNGV RVVLLDRAAA YKFWAPPLTD DPFAPETDLV 600
LVQGPYLVRS ASLSGSTLAL RGDSANETAL EVFASKKVHT VTWNGKRIKT 650
SRSSYGSLTA SLAAPPAVSL PALSSAQWKS QDSLPERLPS YDDSGPAWVD 700
ANHMTTQNPR TPDTLPVLYA DEYGFHNGIR LWRGSFTDAA SGVYLNVQGG 750
AAFGWSAYLN GHFLGSHLGT ATTSQANKTL LFPAGTLRKN TTNTILVIHD 800
DTGHDQTTGA LNPRGILAAR LLAPSDSSTA PNFTQWRVAG TAGGESDLDP 850
VRGVYNEDGL FAERMGWHLP GFDDADWPAN NSTTTRGAQV SLSVTGATVR 900
FFRAVVPLHL PRGVDASISF MLGTPAGAST AYRAQLFVNG YQYGRFYPHI 950
GNQVVYPVPA GVLDYDGENT IGVAVWAQSE AGAEMSLDWR VNYVADSSLD 1000
AVRVAAEGAL RPGWSEERLQ YA 1022
Length:1,022
Mass (Da):111,471
Last modified:July 13, 2010 - v2
Checksum:i032C051812784E46
GO

Sequence cautioni

The sequence EAU34200.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476600 Genomic DNA. Translation: EAU34200.1. Sequence problems.
RefSeqiXP_001214309.1. XM_001214309.1.

Genome annotation databases

GeneIDi4320669.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476600 Genomic DNA. Translation: EAU34200.1 . Sequence problems.
RefSeqi XP_001214309.1. XM_001214309.1.

3D structure databases

ProteinModelPortali Q0CMF3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00004534.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4320669.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiBGALB_ASPTN
AccessioniPrimary (citable) accession number: Q0CMF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi