Reviewed, UniProtKB/Swiss-Prot Q0CLX3 (ATG1_ASPTN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	atg1
ORF Names:	ATEG_05311

Organism

Aspergillus terreus (strain NIH 2624) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	964 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 964	964	Serine/threonine-protein kinase atg1		PRO_0000317790
Regions
	Domain	26 – 331	306	Protein kinase
	Nucleotide binding	32 – 40	9	ATP By similarity
Sites
	Active site	169	1	Proton acceptor By similarity
	Binding site	55	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0CLX3-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: E5834643C699499C	FASTA	964	105,333
	10 20 30 40 50 60 MASAHHSRRP RETSQTSQSE MSVGRYTRLG QIGKGSFATV YQGVHTKSRT YVAIKSVNLS 70 80 90 100 110 120 QLNKKLKENL FSEIHILKGL YHPHIVALID CHETTSHIHL VMEYCALGDL SQFIRHRNTL 130 140 150 160 170 180 GEHRYTRDMI AKYPNPRGGA LNEVVVRHFL KQLASALKFL RDRNLIHRDI KPQNLLLCPS 190 200 210 220 230 240 PTSYRAGVAQ IVPFKGSEDS FSPATGLDSL PMLKIADFGF ARSLPATSLA ETLCGSPLYM 250 260 270 280 290 300 APEILRYEKY DAKADLWSVG TVLYEMVVGK PPFRASNHVE LLRRIERGED NIKFPPENPA 310 320 330 340 350 360 SDDIKALIRM LLKRNPVERM NFADFFESNV ITSPIPGLIP DDTGTLRRPS ADLDPLGQNS 370 380 390 400 410 420 PAEPQPSPGA AAGSRREKDV SREDQITYPQ RTTAQTPRSG TPPSSVPMRR GGSADKAPST 430 440 450 460 470 480 PKDTATTYPQ RPSTVSHATA PGRQELLDRN ATTAAMERQR NRHTFGPSQH ERPVDKAKEE 490 500 510 520 530 540 QERAAQDVAF ERDYVVVEKR AVEVNAFADE LAHSPRIQGG FTRNAQTGAI SRRATVQGPQ 550 560 570 580 590 600 TTATSPLASN TKAMQVFPGR SRADSTHARQ SSYERRYGQS PTSATSAISK ALNMASGRLF 610 620 630 640 650 660 GMGFSPPMAI TKGGRSPPLA YNPFPAYPAA QPTLLPIGDG SKTNATLDED AKTVQVIEEC 670 680 690 700 710 720 ATRSDVVYGF AEVKYKQLIP LAPSVPTDPS GRSSLPGGYR EPSDSTDGGL TVDAVVTLSE 730 740 750 760 770 780 EALVLYVKAL SLLAKSMDIA SAWWNRKNRV DVFGDSTINR TDASMTVVGS RINNVVQWVR 790 800 810 820 830 840 SRFNEVLEKA EFVRLKLIEG QKRLPPDHPS HPNNHSIGSS LGSGASVDVV VSPGVTAEKL 850 860 870 880 890 900 MYDRALEMSR AAAINELTGE DLSGCEIAYV TAIRMLEAVL EEDEMPSTAG DKADRKDGEQ 910 920 930 940 950 960 TMLDSVQAED RQVVVKLVSS IRGRLTALQK KLTVLAKRPT GSLGKTPSSN LTPVAHAVGA TPPR

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH476600 Genomic DNA. Translation: EAU34380.1.
RefSeq	XP_001214489.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4320695.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_ASPTN

Accession

Primary (citable) accession number: Q0CLX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 17, 2006
Last modified:	November 25, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)