ID   PHYA_ASPTN              Reviewed;         466 AA.
AC   Q0CLV1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=3-phytase A;
DE            EC=3.1.3.8;
DE   AltName: Full=3 phytase A;
DE   AltName: Full=Myo-inositol-hexaphosphate 3-phosphohydrolase A;
DE   AltName: Full=Myo-inositol hexakisphosphate phosphohydrolase A;
DE   Flags: Precursor;
GN   Name=phyA; ORFNames=ATEG_05333;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC   mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M.,
RA   Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S.,
RA   White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C.,
RA   Denning D.W., Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of inorganic orthophosphate
CC       from phytate (By similarity).
CC   -!- CATALYTIC ACTIVITY: Myo-inositol hexakisphosphate + H(2)O = 1D-
CC       myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
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DR   EMBL; CH476600; EAU34402.1; -; Genomic_DNA.
DR   RefSeq; XP_001214511.1; -.
DR   GeneID; 4320687; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016158; F:3-phytase activity; IEA:EC.
DR   GO; GO:0003993; F:acid phosphatase activity; IEA:InterPro.
DR   InterPro; IPR000560; Histidine_acid_Pase.
DR   InterPro; IPR016274; Histidine_acid_Pase_euk.
DR   Pfam; PF00328; Acid_phosphat_A; 1.
DR   PIRSF; PIRSF000894; Acid_phosphatase; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Secreted;
KW   Signal.
FT   SIGNAL        1     19       By similarity.
FT   CHAIN        20    466       3-phytase A.
FT                                /FTId=PRO_0000283713.
FT   ACT_SITE     82     82       Nucleophile (By similarity).
FT   ACT_SITE    362    362       Proton donor (By similarity).
FT   CARBOHYD     27     27       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    105    105       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    120    120       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    207    207       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    230    230       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    339    339       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    352    352       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    376    376       N-linked (GlcNAc...) (Potential).
FT   DISULFID     31     40       By similarity.
FT   DISULFID     71    414       By similarity.
FT   DISULFID    215    465       By similarity.
FT   DISULFID    264    282       By similarity.
FT   DISULFID    436    444       By similarity.
SQ   SEQUENCE   466 AA;  51088 MW;  95C75138C6F10045 CRC64;
     MGVFVVLLSI ATLFGSTSGT ALGPRGNHSD CNSVDHGYQC FPELSHKWGL YAPYFSLQDE
     SPFPLDVPDD CQITFVQALA RHGARSPTDS KTKAYAATIA AIQKNATTFP GKYAFLKSYN
     YSMGSEDLTP FGRNQLQDMG AQFYRRYDTL TRHINPFIRA ADSSRVHESA EKFVEGFQNA
     RQGDPRANPH QPSPRVDVVI PEGTAYNNTL EHSICTAFED STVGDAAADN FTAVFAPAIA
     KRLEADLPGV QLSADDVINL MAMCPFETVS LTDDAHTLSP FCDLFTAAEW TQYNYLLSLD
     KYYGYGGGNP LGPVQGVGWA NELIARLTHS PVHDHTCVNN TLDANPATFP LNATLYADFS
     HDSNLVSIFW ALGLYNGTKA LSQTTVEDTT QTDGYAAAWT VPFAARAYIE MMQCRAEKQP
     LVRVLVNDRV MPLHGCAVDN LGRCKRDDFV EGLSFARAGG NWAECF
//