Q0CLV1 (PHYA_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phytase A
EC=3.1.3.8

Alternative name(s):
3 phytase A
Myo-inositol hexakisphosphate phosphohydrolase A
Myo-inositol-hexaphosphate 3-phosphohydrolase A

Gene names

Name:	phyA
ORF Names:	ATEG_05333

Organism

Aspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus terreus

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of inorganic orthophosphate from phytate By similarity.
Catalytic activity	Myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate.
Subunit structure	Monomer By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the histidine acid phosphatase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-phytase activity Inferred from electronic annotation. Source: EC acid phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 466	447	3-phytase A		PRO_0000283713
Sites
	Active site	82	1	Nucleophile By similarity
	Active site	362	1	Proton donor By similarity
Amino acid modifications
	Glycosylation	27	1	N-linked (GlcNAc...) Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	230	1	N-linked (GlcNAc...) Potential
	Glycosylation	339	1	N-linked (GlcNAc...) Potential
	Glycosylation	352	1	N-linked (GlcNAc...) Potential
	Glycosylation	376	1	N-linked (GlcNAc...) Potential
	Disulfide bond	31 ↔ 40		By similarity
	Disulfide bond	71 ↔ 414		By similarity
	Disulfide bond	215 ↔ 465		By similarity
	Disulfide bond	264 ↔ 282		By similarity
	Disulfide bond	436 ↔ 444		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0CLV1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 95C75138C6F10045	FASTA	466	51,088
	10 20 30 40 50 60 MGVFVVLLSI ATLFGSTSGT ALGPRGNHSD CNSVDHGYQC FPELSHKWGL YAPYFSLQDE 70 80 90 100 110 120 SPFPLDVPDD CQITFVQALA RHGARSPTDS KTKAYAATIA AIQKNATTFP GKYAFLKSYN 130 140 150 160 170 180 YSMGSEDLTP FGRNQLQDMG AQFYRRYDTL TRHINPFIRA ADSSRVHESA EKFVEGFQNA 190 200 210 220 230 240 RQGDPRANPH QPSPRVDVVI PEGTAYNNTL EHSICTAFED STVGDAAADN FTAVFAPAIA 250 260 270 280 290 300 KRLEADLPGV QLSADDVINL MAMCPFETVS LTDDAHTLSP FCDLFTAAEW TQYNYLLSLD 310 320 330 340 350 360 KYYGYGGGNP LGPVQGVGWA NELIARLTHS PVHDHTCVNN TLDANPATFP LNATLYADFS 370 380 390 400 410 420 HDSNLVSIFW ALGLYNGTKA LSQTTVEDTT QTDGYAAAWT VPFAARAYIE MMQCRAEKQP 430 440 450 460 LVRVLVNDRV MPLHGCAVDN LGRCKRDDFV EGLSFARAGG NWAECF

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIH 2624 / FGSC A1156.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476600 Genomic DNA. Translation: EAU34402.1.
RefSeq	XP_001214511.1. XM_001214511.1.
3D structure databases
ProteinModelPortal	Q0CLV1.
SMR	Q0CLV1. Positions 31-466.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADATEAT00004553; CADATEAP00004553; CADATEAG00004553.
GeneID	4320687.
Phylogenomic databases
OrthoDB	EOG42Z7ZR.
Family and domain databases
InterPro	IPR000560. His_Pase_superF_clade-2. IPR016274. Histidine_acid_Pase_euk. [Graphical view]
Pfam	PF00328. His_Phos_2. 1 hit. [Graphical view]
PIRSF	PIRSF000894. Acid_phosphatase. 1 hit.
PROSITE	PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHYA_ASPTN

Accession

Primary (citable) accession number: Q0CLV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 17, 2006
Last modified:	July 11, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program