Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene namesi
Name:hse1
ORF Names:ATEG_06036
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_06036.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Class E vacuolar protein-sorting machinery protein hse1PRO_0000292489Add
BLAST

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of HSE1 and VPS27.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ0CJU8.
SMRiQ0CJU8. Positions 229-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 145130VHSPROSITE-ProRule annotationAdd
BLAST
Domaini162 – 18120UIMCuratedAdd
BLAST
Domaini224 – 28360SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi381 – 592212Pro-richAdd
BLAST
Compositional biasi447 – 51973Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the STAM family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOGENOMiHOG000048362.
OMAiMREPDRS.
OrthoDBiEOG092C454D.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CJU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAL
60 70 80 90 100
IKRLAHRNAN VQLYTLELGN ALAQNCGPKI HRELASRSFT DALLRLANDR
110 120 130 140 150
NTHQQVKAKI LERMQEWTEM FASNPDFGIM EQAYMKLKTQ NPNLQPPSKP
160 170 180 190 200
GKREITEADR QKEEEELQMA LALSIREKPS TAPHPQAESS ASAAAAATTP
210 220 230 240 250
TGAASAGQAQ PAASQAVPSG TSAATVSRVR ALFDFQPSEP GELQFRKGDV
260 270 280 290 300
IAVLESVYKD WWKGSLRGQT GIFPLNYVEK LPDPTVEELQ REAQMEAEVF
310 320 330 340 350
GQIKNVEKLL TLLSTRSSEP NVQDNEEITA LYHSTLAIRP KLIELIGKYS
360 370 380 390 400
QKKDEFTQLN EKFIKARRDY EALLEASMSH PAQPQYGRPG QPQYPYPGPG
410 420 430 440 450
APMGYPPGGP QPDQRYFSPR PQGHMYPPTS QSPGPRNHTP PAAAPYQQAP
460 470 480 490 500
SHPPAQPQQH TAPDAYPPQH HRPESTYDHP QELSTSVYDS PVEQRPPYPG
510 520 530 540 550
AQIPAAIHQH FQQQQQQQQD YSPSVYSPDE SKPPGTQQVP YPATPAANQP
560 570 580 590
PPMHQPPPVP GAAAAPTPYP VNAPGASYQA YKPPQGGPAS NPASFYQ
Length:597
Mass (Da):65,592
Last modified:October 17, 2006 - v1
Checksum:i6889980721DD6CEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476601 Genomic DNA. Translation: EAU33797.1.
RefSeqiXP_001215214.1. XM_001215214.1.

Genome annotation databases

EnsemblFungiiCADATEAT00001453; CADATEAP00001453; CADATEAG00001453.
GeneIDi4321440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476601 Genomic DNA. Translation: EAU33797.1.
RefSeqiXP_001215214.1. XM_001215214.1.

3D structure databases

ProteinModelPortaliQ0CJU8.
SMRiQ0CJU8. Positions 229-278.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00001453; CADATEAP00001453; CADATEAG00001453.
GeneIDi4321440.

Organism-specific databases

EuPathDBiFungiDB:ATEG_06036.

Phylogenomic databases

HOGENOMiHOG000048362.
OMAiMREPDRS.
OrthoDBiEOG092C454D.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSE1_ASPTN
AccessioniPrimary (citable) accession number: Q0CJU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.