Q0CIL2 (XKS1_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable D-xylulose kinase A
Short name=Xylulokinase A
EC=2.7.1.17

Gene names

Name:	xkiA
ORF Names:	ATEG_06472

Organism

Aspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus terreus

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.
Catalytic activity	ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
Subcellular location	Cytoplasm By similarity.
Induction	By D-xylose, L-arabinose or L-arabitol.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xylulokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 573	573	Probable D-xylulose kinase A		PRO_0000393523

Sequences

	Sequence		Length	Mass (Da)
	Q0CIL2 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: DE092A70270D0BAA	FASTA	573	63,415
	10 20 30 40 50 60 MAISAAQNPL YIGFDLSTQQ LKGLVVNSDL KVVYLSKFDF DADSRGFPIK KGVITNEAEH 70 80 90 100 110 120 EVYAPVAMWL QALDTVLDGL RQQGLDFSRV KGISGAGQQH GSVYWGDRAE DLLQNLDPSK 130 140 150 160 170 180 SLEAQLSDAF SHPYSPNWQD ASTQKECDEF DAYLGSQEAL AQATGSKAHH RFTGPQILRF 190 200 210 220 230 240 QRKYPDVYRH TQRISLVSSF LASLFLGRFA PFDISDVCGM NLWNIKQGAY DEKLLKLCAG 250 260 270 280 290 300 SFGVDDLKRK LGPVYEDGGL NLGSIHRYYV DRYGFNPDCT IIPATGDNPA TILALPLRPS 310 320 330 340 350 360 DAMVSLGTST TFLMSTPSYQ PHPATHFFNH PTTAGLYMFM LCYKNGGLAR EQIRDAVNDK 370 380 390 400 410 420 LGSSDDVWAN FDRTALQTPP LGQKADSDPM KMGLFFPRPE IVPNLRSGQW RFDYNPADGS 430 440 450 460 470 480 LHETTAGWDQ PLDEARAIIE SQMLSLRLRS RGLTSSPGDG KPPQPRRVYL VGGGSKNKAI 490 500 510 520 530 540 AKIAGEILGG SEGVYKLEIG DNACALGAAY KAVWALERSN GQTFEDLIGQ RWKEEDFIEK 550 560 570 IADGYQPGVF EKYGQAVEGF EKMELQVLQQ EKK

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIH 2624 / FGSC A1156.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476602 Genomic DNA. Translation: EAU33016.1.
RefSeq	XP_001215650.1. XM_001215650.1.
3D structure databases
ProteinModelPortal	Q0CIL2.
ModBase	Search...
Protein-protein interaction databases
STRING	33178.CADATEAP00007642.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADATEAT00007642; CADATEAP00007642; CADATEAG00007642.
GeneID	4322249.
Phylogenomic databases
eggNOG	COG1070.
HOGENOM	HOG000174850.
OrthoDB	EOG4578GH.
Family and domain databases
InterPro	IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. [Graphical view]
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XKS1_ASPTN

Accession

Primary (citable) accession number: Q0CIL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 20, 2010
Last sequence update:	October 17, 2006
Last modified:	April 3, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program