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Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Binding sitei287SubstrateBy similarity1
Binding sitei288SubstrateBy similarity1
Binding sitei368ATPBy similarity1
Binding sitei477ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi473 – 474ATPBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:ATEG_06472
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_06472.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003935231 – 573Probable D-xylulose kinase AAdd BLAST573

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Structurei

3D structure databases

ProteinModelPortaliQ0CIL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000174850.
OMAiCGMNLYD.
OrthoDBiEOG092C1IUM.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CIL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISAAQNPL YIGFDLSTQQ LKGLVVNSDL KVVYLSKFDF DADSRGFPIK
60 70 80 90 100
KGVITNEAEH EVYAPVAMWL QALDTVLDGL RQQGLDFSRV KGISGAGQQH
110 120 130 140 150
GSVYWGDRAE DLLQNLDPSK SLEAQLSDAF SHPYSPNWQD ASTQKECDEF
160 170 180 190 200
DAYLGSQEAL AQATGSKAHH RFTGPQILRF QRKYPDVYRH TQRISLVSSF
210 220 230 240 250
LASLFLGRFA PFDISDVCGM NLWNIKQGAY DEKLLKLCAG SFGVDDLKRK
260 270 280 290 300
LGPVYEDGGL NLGSIHRYYV DRYGFNPDCT IIPATGDNPA TILALPLRPS
310 320 330 340 350
DAMVSLGTST TFLMSTPSYQ PHPATHFFNH PTTAGLYMFM LCYKNGGLAR
360 370 380 390 400
EQIRDAVNDK LGSSDDVWAN FDRTALQTPP LGQKADSDPM KMGLFFPRPE
410 420 430 440 450
IVPNLRSGQW RFDYNPADGS LHETTAGWDQ PLDEARAIIE SQMLSLRLRS
460 470 480 490 500
RGLTSSPGDG KPPQPRRVYL VGGGSKNKAI AKIAGEILGG SEGVYKLEIG
510 520 530 540 550
DNACALGAAY KAVWALERSN GQTFEDLIGQ RWKEEDFIEK IADGYQPGVF
560 570
EKYGQAVEGF EKMELQVLQQ EKK
Length:573
Mass (Da):63,415
Last modified:October 17, 2006 - v1
Checksum:iDE092A70270D0BAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33016.1.
RefSeqiXP_001215650.1. XM_001215650.1.

Genome annotation databases

EnsemblFungiiCADATEAT00007642; CADATEAP00007642; CADATEAG00007642.
GeneIDi4322249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33016.1.
RefSeqiXP_001215650.1. XM_001215650.1.

3D structure databases

ProteinModelPortaliQ0CIL2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00007642; CADATEAP00007642; CADATEAG00007642.
GeneIDi4322249.

Organism-specific databases

EuPathDBiFungiDB:ATEG_06472.

Phylogenomic databases

HOGENOMiHOG000174850.
OMAiCGMNLYD.
OrthoDBiEOG092C1IUM.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXKS1_ASPTN
AccessioniPrimary (citable) accession number: Q0CIL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.