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Q0CIL2

- XKS1_ASPTN

UniProt

Q0CIL2 - XKS1_ASPTN

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Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001SubstrateBy similarity
Binding sitei171 – 1711SubstrateBy similarity
Binding sitei287 – 2871SubstrateBy similarity
Binding sitei288 – 2881SubstrateBy similarity
Binding sitei368 – 3681ATPBy similarity
Binding sitei477 – 4771ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi473 – 4742ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:ATEG_06472
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Probable D-xylulose kinase APRO_0000393523Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00007642.

Structurei

3D structure databases

ProteinModelPortaliQ0CIL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
OMAiMICYCNG.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CIL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAISAAQNPL YIGFDLSTQQ LKGLVVNSDL KVVYLSKFDF DADSRGFPIK
60 70 80 90 100
KGVITNEAEH EVYAPVAMWL QALDTVLDGL RQQGLDFSRV KGISGAGQQH
110 120 130 140 150
GSVYWGDRAE DLLQNLDPSK SLEAQLSDAF SHPYSPNWQD ASTQKECDEF
160 170 180 190 200
DAYLGSQEAL AQATGSKAHH RFTGPQILRF QRKYPDVYRH TQRISLVSSF
210 220 230 240 250
LASLFLGRFA PFDISDVCGM NLWNIKQGAY DEKLLKLCAG SFGVDDLKRK
260 270 280 290 300
LGPVYEDGGL NLGSIHRYYV DRYGFNPDCT IIPATGDNPA TILALPLRPS
310 320 330 340 350
DAMVSLGTST TFLMSTPSYQ PHPATHFFNH PTTAGLYMFM LCYKNGGLAR
360 370 380 390 400
EQIRDAVNDK LGSSDDVWAN FDRTALQTPP LGQKADSDPM KMGLFFPRPE
410 420 430 440 450
IVPNLRSGQW RFDYNPADGS LHETTAGWDQ PLDEARAIIE SQMLSLRLRS
460 470 480 490 500
RGLTSSPGDG KPPQPRRVYL VGGGSKNKAI AKIAGEILGG SEGVYKLEIG
510 520 530 540 550
DNACALGAAY KAVWALERSN GQTFEDLIGQ RWKEEDFIEK IADGYQPGVF
560 570
EKYGQAVEGF EKMELQVLQQ EKK
Length:573
Mass (Da):63,415
Last modified:October 17, 2006 - v1
Checksum:iDE092A70270D0BAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33016.1.
RefSeqiXP_001215650.1. XM_001215650.1.

Genome annotation databases

EnsemblFungiiCADATEAT00007642; CADATEAP00007642; CADATEAG00007642.
GeneIDi4322249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33016.1 .
RefSeqi XP_001215650.1. XM_001215650.1.

3D structure databases

ProteinModelPortali Q0CIL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00007642.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00007642 ; CADATEAP00007642 ; CADATEAG00007642 .
GeneIDi 4322249.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000174850.
OMAi MICYCNG.
OrthoDBi EOG7CRTZN.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiXKS1_ASPTN
AccessioniPrimary (citable) accession number: Q0CIL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3