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Q0CIL2

- XKS1_ASPTN

UniProt

Q0CIL2 - XKS1_ASPTN

Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.By similarity

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001SubstrateBy similarity
    Binding sitei171 – 1711SubstrateBy similarity
    Binding sitei287 – 2871SubstrateBy similarity
    Binding sitei288 – 2881SubstrateBy similarity
    Binding sitei368 – 3681ATPBy similarity
    Binding sitei477 – 4771ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi473 – 4742ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable D-xylulose kinase A (EC:2.7.1.17)
    Short name:
    Xylulokinase A
    Gene namesi
    Name:xkiA
    ORF Names:ATEG_06472
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Probable D-xylulose kinase APRO_0000393523Add
    BLAST

    Expressioni

    Inductioni

    By D-xylose, L-arabinose or L-arabitol.

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00007642.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CIL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.
    HOGENOMiHOG000174850.
    OMAiMICYCNG.
    OrthoDBiEOG7CRTZN.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0CIL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAISAAQNPL YIGFDLSTQQ LKGLVVNSDL KVVYLSKFDF DADSRGFPIK    50
    KGVITNEAEH EVYAPVAMWL QALDTVLDGL RQQGLDFSRV KGISGAGQQH 100
    GSVYWGDRAE DLLQNLDPSK SLEAQLSDAF SHPYSPNWQD ASTQKECDEF 150
    DAYLGSQEAL AQATGSKAHH RFTGPQILRF QRKYPDVYRH TQRISLVSSF 200
    LASLFLGRFA PFDISDVCGM NLWNIKQGAY DEKLLKLCAG SFGVDDLKRK 250
    LGPVYEDGGL NLGSIHRYYV DRYGFNPDCT IIPATGDNPA TILALPLRPS 300
    DAMVSLGTST TFLMSTPSYQ PHPATHFFNH PTTAGLYMFM LCYKNGGLAR 350
    EQIRDAVNDK LGSSDDVWAN FDRTALQTPP LGQKADSDPM KMGLFFPRPE 400
    IVPNLRSGQW RFDYNPADGS LHETTAGWDQ PLDEARAIIE SQMLSLRLRS 450
    RGLTSSPGDG KPPQPRRVYL VGGGSKNKAI AKIAGEILGG SEGVYKLEIG 500
    DNACALGAAY KAVWALERSN GQTFEDLIGQ RWKEEDFIEK IADGYQPGVF 550
    EKYGQAVEGF EKMELQVLQQ EKK 573
    Length:573
    Mass (Da):63,415
    Last modified:October 17, 2006 - v1
    Checksum:iDE092A70270D0BAA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33016.1.
    RefSeqiXP_001215650.1. XM_001215650.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00007642; CADATEAP00007642; CADATEAG00007642.
    GeneIDi4322249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33016.1 .
    RefSeqi XP_001215650.1. XM_001215650.1.

    3D structure databases

    ProteinModelPortali Q0CIL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00007642.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00007642 ; CADATEAP00007642 ; CADATEAG00007642 .
    GeneIDi 4322249.

    Phylogenomic databases

    eggNOGi COG1070.
    HOGENOMi HOG000174850.
    OMAi MICYCNG.
    OrthoDBi EOG7CRTZN.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiXKS1_ASPTN
    AccessioniPrimary (citable) accession number: Q0CIL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3