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Q0CIC7 (MPKC_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase mpkC

Short name=MAP kinase C
EC=2.7.11.24
Gene names
Name:mpkC
ORF Names:ATEG_06557
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-170 and Tyr-172, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence EAU33101.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 370370Mitogen-activated protein kinase mpkC
PRO_0000289716

Regions

Domain19 – 298280Protein kinase
Nucleotide binding25 – 339ATP By similarity
Motif170 – 1723TXY

Sites

Active site1401Proton acceptor By similarity
Binding site481ATP By similarity

Amino acid modifications

Modified residue1701Phosphothreonine By similarity
Modified residue1721Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0CIC7 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: 34405D9F5FEA3EF4

FASTA37042,635
        10         20         30         40         50         60 
MDFIRSEILG TKFETTIRYA NVRPVGLGAF GLVCSAYDQI TQQSVAIKKM MSPFASSAIA 

        70         80         90        100        110        120 
KRTYREVKLL KKLRHENLIG LCDIFISPLE DIYLVTELLG TDLSRLLRSK PLENKFAQFF 

       130        140        150        160        170        180 
MYQLMRGLKY IHSAGVIHRD LKPSNLLINE NCDLKICDFG LARVQEPRMT GYVSTRYYRA 

       190        200        210        220        230        240 
PEIMLTWQRY GVEVDIWSAG CILAEMLRGV PLFPGKDHIN QFYLITDMIG NPPLEVIEKI 

       250        260        270        280        290        300 
TSKNTRHIVD SLPHKEPRQL KTIFNEEDAE AVDLLEKMLL FDQSKRISAA ESLEHPYLAP 

       310        320        330        340        350        360 
YHDPTDEPVA EEKFDWSFND ADLPKESWKY MIYSEVLDFH SMEAHSSGYM TQDDFASVLE 

       370 
FVDQNQFAET 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476602 Genomic DNA. Translation: EAU33101.1. Sequence problems.
RefSeqXP_001215735.1. XM_001215735.1.

3D structure databases

ProteinModelPortalQ0CIC7.
SMRQ0CIC7. Positions 2-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00006482.

Proteomic databases

PRIDEQ0CIC7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4322342.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPKC_ASPTN
AccessionPrimary (citable) accession number: Q0CIC7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families