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Q0CIC7

- MPKC_ASPTN

UniProt

Q0CIC7 - MPKC_ASPTN

Protein

Mitogen-activated protein kinase mpkC

Gene

mpkC

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by tyrosine and threonine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481ATPPROSITE-ProRule annotation
    Active sitei140 – 1401Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi25 – 339ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase mpkC (EC:2.7.11.24)
    Short name:
    MAP kinase C
    Gene namesi
    Name:mpkC
    ORF Names:ATEG_06557
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Mitogen-activated protein kinase mpkCPRO_0000289716Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei170 – 1701PhosphothreonineBy similarity
    Modified residuei172 – 1721PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-170 and Tyr-172, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ0CIC7.

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00006482.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CIC7.
    SMRiQ0CIC7. Positions 2-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 298280Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi170 – 1723TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0CIC7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFIRSEILG TKFETTIRYA NVRPVGLGAF GLVCSAYDQI TQQSVAIKKM    50
    MSPFASSAIA KRTYREVKLL KKLRHENLIG LCDIFISPLE DIYLVTELLG 100
    TDLSRLLRSK PLENKFAQFF MYQLMRGLKY IHSAGVIHRD LKPSNLLINE 150
    NCDLKICDFG LARVQEPRMT GYVSTRYYRA PEIMLTWQRY GVEVDIWSAG 200
    CILAEMLRGV PLFPGKDHIN QFYLITDMIG NPPLEVIEKI TSKNTRHIVD 250
    SLPHKEPRQL KTIFNEEDAE AVDLLEKMLL FDQSKRISAA ESLEHPYLAP 300
    YHDPTDEPVA EEKFDWSFND ADLPKESWKY MIYSEVLDFH SMEAHSSGYM 350
    TQDDFASVLE FVDQNQFAET 370
    Length:370
    Mass (Da):42,635
    Last modified:May 29, 2007 - v2
    Checksum:i34405D9F5FEA3EF4
    GO

    Sequence cautioni

    The sequence EAU33101.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33101.1. Sequence problems.
    RefSeqiXP_001215735.1. XM_001215735.1.

    Genome annotation databases

    GeneIDi4322342.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33101.1 . Sequence problems.
    RefSeqi XP_001215735.1. XM_001215735.1.

    3D structure databases

    ProteinModelPortali Q0CIC7.
    SMRi Q0CIC7. Positions 2-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00006482.

    Proteomic databases

    PRIDEi Q0CIC7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4322342.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiMPKC_ASPTN
    AccessioniPrimary (citable) accession number: Q0CIC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3