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Q0CI96

- BTGC_ASPTN

UniProt

Q0CI96 - BTGC_ASPTN

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Protein

Probable glucan endo-1,3-beta-glucosidase btgC

Gene

btgC

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan By similarity.By similarity

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei557 – 5571NucleophileBy similarity
Active sitei625 – 6251Proton donorBy similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan endo-1,3-beta-glucosidase btgC (EC:3.2.1.39)
Alternative name(s):
Endo-1,3-beta-glucanase btgC
Laminarinase btgC
Gene namesi
Name:btgC
ORF Names:ATEG_06588
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 655655Probable glucan endo-1,3-beta-glucosidase btgCPRO_0000395127Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi602 – 6021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 282282CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini304 – 655352ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei283 – 30321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi143 – 15513Poly-AlaAdd
BLAST
Compositional biasi228 – 30881Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000173877.
OrthoDBiEOG7P8PHC.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0CI96-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSGDPRSFSF NQGDDHPIDS SQQPLHPTNT MADSYSDRNW GAPGGLDHTH
60 70 80 90 100
SMRTQSTATP GMDNLGPAAV GGGISGIALG VANSHDRQSG VDAFRDTDGG
110 120 130 140 150
NFPAERGYNA PGSDNPYVPP PPAAAYDSSD NLTARSGAYG SSAALAAAAS
160 170 180 190 200
APAGASNTSR RSFVDSPYQG VGALDAGPYQ RQSVYNNGDY PLVINPDEII
210 220 230 240 250
DDGDDGFALP NSKSAGHKSR AVPAAAAGAA GGAAAGGLLG GIFKSKAAAE
260 270 280 290 300
GPSYGPVPGA GIEAAEKGQW AKPKPGTGSR KRGWIVGIIL AVVIVGAIVG
310 320 330 340 350
GAVGGTLGNR EKESPSSSET ASGDEKVNGD LGKDSDEIKS LMNNPNLHKV
360 370 380 390 400
FPGMDYTPWG TQYPLCQKYP PSQNNVTRDI AVLSQLTNTV RLYGTDCNQT
410 420 430 440 450
EMVLHAIDRL ELTEMKLWLG VWIDTNKTTC ERQLNQLYDV LDKTKDHSIF
460 470 480 490 500
KGAIIGNEAL YRAGSSIAEA EKTLISYMTE VRDHFKKNNI NIPIATSDLG
510 520 530 540 550
DNWNAELVKA SDVVMANVHP FFAGVSVDLA ASWTWDFWNN HNLVLTKGTD
560 570 580 590 600
KKQIISEVGW PSGGGNDCGD GGNCPNDSAG SVAGIDEMNQ FMSDWVCQAL
610 620 630 640 650
DNGTDYFWFE AFDEPWKIVY NTKNENWEDK WGLMDPARNL KDGLKIPDCG

GKTAT
Length:655
Mass (Da):69,420
Last modified:June 15, 2010 - v2
Checksum:iC2560B77C3B3CAC5
GO

Sequence cautioni

The sequence EAU33132.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence EAU33132.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33132.1. Sequence problems.
RefSeqiXP_001215766.1. XM_001215766.1.

Genome annotation databases

GeneIDi4322381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33132.1 . Sequence problems.
RefSeqi XP_001215766.1. XM_001215766.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4322381.

Phylogenomic databases

eggNOGi COG5309.
HOGENOMi HOG000173877.
OrthoDBi EOG7P8PHC.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiBTGC_ASPTN
AccessioniPrimary (citable) accession number: Q0CI96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 35 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3