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Q0CI79

- PMIP_ASPTN

UniProt

Q0CI79 - PMIP_ASPTN

Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
    Active sitei566 – 5661PROSITE-ProRule annotation
    Metal bindingi569 – 5691Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi572 – 5721Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct1
    ORF Names:ATEG_06605
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionSequence AnalysisAdd
    BLAST
    Chaini25 – 802778Mitochondrial intermediate peptidasePRO_0000338574Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00008513.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CI79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0CI79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGPKLLMPL RPRPWTCRTC LQRLHSARRS LKTAASPSPQ STSFEYNRSA    50
    HNTQKSTTDD ETLRRVFDSP SFWKEFSQRS SLHTKPTGLV QNQYLTSPEG 100
    FRTFANVSLH KCQAIVHKVL AASTLEEYRD MARDLDRLSD LLCRVIDLSD 150
    FIRVIHPDPQ VQEAATQAYA LMFDYMNVLN TTTGLNDQLK KAAANPDVTS 200
    HWSAEEKIVA QILIKDFSNS AIHMPPNERQ RFVNLSNEIS QLGSNFVNAA 250
    EPAKSHVVVG TNSLRGLDPL LVQQIKRWNR TASVPTMGMI PRLVLRSVHD 300
    EGVRKDVYLA TRTSSSRQIK RLEQLLAKRA ELAQLSGYAS FGHMTLSDKM 350
    AKSPEAVSNF LTSLVGSNRQ FVHEELAQLQ GMKGSSPLQA WDHAYYVHQR 400
    VMQYSQSRRS RELSIVPEFF SLGTVMQGLS RLFNRLYGVR LVPQETAPGE 450
    TWNPDVRRLD VVDEAERHIA VIYCDLFSRP NKHPNPAHFT LRCSREISNQ 500
    EVAECASMDQ SAHPNDGMAT AVDPQSKTLR QLPTIALVCD FPDPPATSAG 550
    RPSLLSEHSV RTLFHEMGHA LHSILGQTRL QSISGTRCAT DFAELPSVLM 600
    ERFATAPEVL SMYARHWQTD QPLSENMMRS MEQDRTAHGS IYGAVENEAQ 650
    ILMALVDQAY HSVPAEAAGK IDSTAIYHQV SQAHSSLPEP SDTQPPTSWQ 700
    GFFGHLYGYG ATYYSYIFDR AIANKLWEDV FQSGQASVDR NAGERYKNEV 750
    LRWGGGRNGW DCVAGVLGSG NPSNADGRLV EGGDDAMREV GRWGLGRDGV 800
    SG 802
    Length:802
    Mass (Da):89,472
    Last modified:June 10, 2008 - v2
    Checksum:i3E92F4BA281CEB5F
    GO

    Sequence cautioni

    The sequence EAU33149.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence EAU33149.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33149.1. Sequence problems.
    RefSeqiXP_001215783.1. XM_001215783.1.

    Genome annotation databases

    GeneIDi4322361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33149.1 . Sequence problems.
    RefSeqi XP_001215783.1. XM_001215783.1.

    3D structure databases

    ProteinModelPortali Q0CI79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00008513.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4322361.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiPMIP_ASPTN
    AccessioniPrimary (citable) accession number: Q0CI79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3