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Q0CI79

- PMIP_ASPTN

UniProt

Q0CI79 - PMIP_ASPTN

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Protein

Mitochondrial intermediate peptidase

Gene
oct1, ATEG_06605
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi565 – 5651Zinc; catalytic By similarity
Active sitei566 – 5661 By similarity
Metal bindingi569 – 5691Zinc; catalytic By similarity
Metal bindingi572 – 5721Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:ATEG_06605
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion Reviewed predictionAdd
BLAST
Chaini25 – 802778Mitochondrial intermediate peptidasePRO_0000338574Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00008513.

Structurei

3D structure databases

ProteinModelPortaliQ0CI79.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CI79-1 [UniParc]FASTAAdd to Basket

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MGGPKLLMPL RPRPWTCRTC LQRLHSARRS LKTAASPSPQ STSFEYNRSA    50
HNTQKSTTDD ETLRRVFDSP SFWKEFSQRS SLHTKPTGLV QNQYLTSPEG 100
FRTFANVSLH KCQAIVHKVL AASTLEEYRD MARDLDRLSD LLCRVIDLSD 150
FIRVIHPDPQ VQEAATQAYA LMFDYMNVLN TTTGLNDQLK KAAANPDVTS 200
HWSAEEKIVA QILIKDFSNS AIHMPPNERQ RFVNLSNEIS QLGSNFVNAA 250
EPAKSHVVVG TNSLRGLDPL LVQQIKRWNR TASVPTMGMI PRLVLRSVHD 300
EGVRKDVYLA TRTSSSRQIK RLEQLLAKRA ELAQLSGYAS FGHMTLSDKM 350
AKSPEAVSNF LTSLVGSNRQ FVHEELAQLQ GMKGSSPLQA WDHAYYVHQR 400
VMQYSQSRRS RELSIVPEFF SLGTVMQGLS RLFNRLYGVR LVPQETAPGE 450
TWNPDVRRLD VVDEAERHIA VIYCDLFSRP NKHPNPAHFT LRCSREISNQ 500
EVAECASMDQ SAHPNDGMAT AVDPQSKTLR QLPTIALVCD FPDPPATSAG 550
RPSLLSEHSV RTLFHEMGHA LHSILGQTRL QSISGTRCAT DFAELPSVLM 600
ERFATAPEVL SMYARHWQTD QPLSENMMRS MEQDRTAHGS IYGAVENEAQ 650
ILMALVDQAY HSVPAEAAGK IDSTAIYHQV SQAHSSLPEP SDTQPPTSWQ 700
GFFGHLYGYG ATYYSYIFDR AIANKLWEDV FQSGQASVDR NAGERYKNEV 750
LRWGGGRNGW DCVAGVLGSG NPSNADGRLV EGGDDAMREV GRWGLGRDGV 800
SG 802
Length:802
Mass (Da):89,472
Last modified:June 10, 2008 - v2
Checksum:i3E92F4BA281CEB5F
GO

Sequence cautioni

The sequence EAU33149.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence EAU33149.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33149.1. Sequence problems.
RefSeqiXP_001215783.1. XM_001215783.1.

Genome annotation databases

GeneIDi4322361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33149.1 . Sequence problems.
RefSeqi XP_001215783.1. XM_001215783.1.

3D structure databases

ProteinModelPortali Q0CI79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00008513.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4322361.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiPMIP_ASPTN
AccessioniPrimary (citable) accession number: Q0CI79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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