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Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
Active sitei566 – 5661PROSITE-ProRule annotation
Metal bindingi569 – 5691Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi572 – 5721Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:ATEG_06605
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_06605.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence AnalysisAdd
BLAST
Chaini25 – 802778Mitochondrial intermediate peptidasePRO_0000338574Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0CI79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CI79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGPKLLMPL RPRPWTCRTC LQRLHSARRS LKTAASPSPQ STSFEYNRSA
60 70 80 90 100
HNTQKSTTDD ETLRRVFDSP SFWKEFSQRS SLHTKPTGLV QNQYLTSPEG
110 120 130 140 150
FRTFANVSLH KCQAIVHKVL AASTLEEYRD MARDLDRLSD LLCRVIDLSD
160 170 180 190 200
FIRVIHPDPQ VQEAATQAYA LMFDYMNVLN TTTGLNDQLK KAAANPDVTS
210 220 230 240 250
HWSAEEKIVA QILIKDFSNS AIHMPPNERQ RFVNLSNEIS QLGSNFVNAA
260 270 280 290 300
EPAKSHVVVG TNSLRGLDPL LVQQIKRWNR TASVPTMGMI PRLVLRSVHD
310 320 330 340 350
EGVRKDVYLA TRTSSSRQIK RLEQLLAKRA ELAQLSGYAS FGHMTLSDKM
360 370 380 390 400
AKSPEAVSNF LTSLVGSNRQ FVHEELAQLQ GMKGSSPLQA WDHAYYVHQR
410 420 430 440 450
VMQYSQSRRS RELSIVPEFF SLGTVMQGLS RLFNRLYGVR LVPQETAPGE
460 470 480 490 500
TWNPDVRRLD VVDEAERHIA VIYCDLFSRP NKHPNPAHFT LRCSREISNQ
510 520 530 540 550
EVAECASMDQ SAHPNDGMAT AVDPQSKTLR QLPTIALVCD FPDPPATSAG
560 570 580 590 600
RPSLLSEHSV RTLFHEMGHA LHSILGQTRL QSISGTRCAT DFAELPSVLM
610 620 630 640 650
ERFATAPEVL SMYARHWQTD QPLSENMMRS MEQDRTAHGS IYGAVENEAQ
660 670 680 690 700
ILMALVDQAY HSVPAEAAGK IDSTAIYHQV SQAHSSLPEP SDTQPPTSWQ
710 720 730 740 750
GFFGHLYGYG ATYYSYIFDR AIANKLWEDV FQSGQASVDR NAGERYKNEV
760 770 780 790 800
LRWGGGRNGW DCVAGVLGSG NPSNADGRLV EGGDDAMREV GRWGLGRDGV

SG
Length:802
Mass (Da):89,472
Last modified:June 10, 2008 - v2
Checksum:i3E92F4BA281CEB5F
GO

Sequence cautioni

The sequence EAU33149.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAU33149.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33149.1. Sequence problems.
RefSeqiXP_001215783.1. XM_001215783.1.

Genome annotation databases

GeneIDi4322361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33149.1. Sequence problems.
RefSeqiXP_001215783.1. XM_001215783.1.

3D structure databases

ProteinModelPortaliQ0CI79.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4322361.

Organism-specific databases

EuPathDBiFungiDB:ATEG_06605.

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiPMIP_ASPTN
AccessioniPrimary (citable) accession number: Q0CI79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 22, 2015
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.