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Q0CI48

- MANBA_ASPTN

UniProt

Q0CI48 - MANBA_ASPTN

Protein

Beta-mannosidase A

Gene

mndA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 2 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei480 – 4801Proton donorBy similarity

    GO - Molecular functioni

    1. beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00280.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-mannosidase A (EC:3.2.1.25)
    Alternative name(s):
    Mannanase A
    Short name:
    Mannase A
    Gene namesi
    Name:mndA
    ORF Names:ATEG_06636
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 932913Beta-mannosidase APRO_0000394648Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi551 – 5511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi739 – 7391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00009356.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000216059.
    OMAiCHATQLF.
    OrthoDBiEOG78D7TH.

    Family and domain databases

    InterProiIPR006102. Glyco_hydro_2_Ig-like.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0CI48-1 [UniParc]FASTAAdd to Basket

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    MRVPAQATIA VLASAVSSPL NDPQIYDLGK LGWTLSSPAL NRTVPGHLPS    50
    QVHLDLLRAG VIDDPYHDLN DFNLRWIADA NWTYTSDPIR GLGNNTHSTW 100
    LVFEGLDTFA TIKYCDKQIA STNNQFRQYA FDISEAVKDC TADPVLSLNF 150
    GSAPKIVDQI AADPASPQWP FGIQQSYEYP NRWFMRKEQS DFGWDWGPAF 200
    APAGPWKPAY LVQLSSEQNV HVLNTDLDIY RQGQINYLPP DQTQPWVLNA 250
    SIDFFGSLPS NSSMSIAISE TNSGAELTTQ SLRNITILNG SITGVAVLKD 300
    ASPKLWWPYG LGEQNLYNVT ITVSDGVRSL ARVTKRTGFR TIFLNQRNIT 350
    DTEIAQGVAP GAHWNFEVNG HEFYAKGSNL IPPDAFWARV TTTKMARLFD 400
    SVVAANQNML RVWSSGAYLP DFMYDLADER GVLLWSEFEF SDAMYPVDKA 450
    FLDNVAAEVV YNVRRVNHHP SLALWAGGNE IESLILPTIE RSYPDQYAKY 500
    VGDYETLYIN LILPLVYENT HSITYSPSST TEGYLDVNLS AKIVMAERYQ 550
    NLTEGHYYGD TDYYNYDTSV AFDFSQYPVG RFANEFGFHS MPSLQSWQQA 600
    VDPEDLHFNS SVIMLRNHHY PAGNLSTHNF HNTSMGMGET TMGVMNYYPV 650
    PDKTDPIANF SAWCHATQLF QADFYKSQIQ FYRRGSGMPE RQLGSLYWQL 700
    EDIWQAPSWA GIEYDGRWKV LHYVARDIYQ PVIVSPFWNS TTRRLDVYVT 750
    SDLWEPVSGT VDLAWMDLSG KPIAQNARTP KTAAFVVGAL NTTKIYSMNI 800
    NERALPDPKN SVLILSVQAE GHLPNSNKKS TLTHQGHFTP VFPKDLMLVD 850
    PHLELRYNAK TLTFTVQAKA GVSLYTWLDY PAGVVGYFED NGFVLVPGQK 900
    RDIRFVMQED KTDGNWVQDV TVRSLWDQTT KT 932
    Length:932
    Mass (Da):105,189
    Last modified:March 19, 2014 - v2
    Checksum:i2B1436F3E4E53D88
    GO

    Sequence cautioni

    The sequence EAU33180.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33180.1. Sequence problems.
    RefSeqiXP_001215814.1. XM_001215814.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00009356; CADATEAP00009356; CADATEAG00009356.
    GeneIDi4321960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476602 Genomic DNA. Translation: EAU33180.1 . Sequence problems.
    RefSeqi XP_001215814.1. XM_001215814.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00009356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00009356 ; CADATEAP00009356 ; CADATEAG00009356 .
    GeneIDi 4321960.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000216059.
    OMAi CHATQLF.
    OrthoDBi EOG78D7TH.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .

    Family and domain databases

    InterProi IPR006102. Glyco_hydro_2_Ig-like.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.
    2. "Phylogenetic analysis and substrate specificity of GH2 beta-mannosidases from Aspergillus species."
      Reddy S.K., Rosengren A., Klaubauf S., Kulkarni T., Karlsson E.N., de Vries R.P., Stalbrand H.
      FEBS Lett. 587:3444-3449(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE MODEL REVISION.

    Entry informationi

    Entry nameiMANBA_ASPTN
    AccessioniPrimary (citable) accession number: Q0CI48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3