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Q0CI48 (MANBA_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-mannosidase A
EC=3.2.1.25
Alternative name(s):
Mannanase A
Short name=Mannase A
Gene names
Name:mndA
ORF Names:ATEG_06636
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus ›

Protein attributes

Sequence length783 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides. Involved in the degradation of mannan and galactomannan By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathway

Glycan metabolism; N-glycan degradation.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-mannosidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 783764Probable beta-mannosidase A
PRO_0000394648

Sites

Active site4461Proton donor By similarity

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2551N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation5041N-linked (GlcNAc...) Potential
Glycosylation5171N-linked (GlcNAc...) Potential
Glycosylation5751N-linked (GlcNAc...) Potential
Glycosylation5901N-linked (GlcNAc...) Potential
Glycosylation5981N-linked (GlcNAc...) Potential
Glycosylation6251N-linked (GlcNAc...) Potential
Glycosylation7051N-linked (GlcNAc...) Potential
Glycosylation7571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0CI48 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: DA41290DB2C67DBD

FASTA78388,526
        10         20         30         40         50         60 
MRVPAQATIA VLASAVSSPL NDPQIYDLDD PYHDLNDFNL RWIADANWTY TSDPIRGLGN 

        70         80         90        100        110        120 
NTHSTWLVFE GLDTFATIKY CDKQIASTNN QFRQYAFDIS EAVKDCTADP VLSLNFGSAP 

       130        140        150        160        170        180 
KIVDQIAADP ASPQWPFGIQ QSYEYPNRWF MRKEQSDFGW DWGPAFAPAG PWKPAYLVQL 

       190        200        210        220        230        240 
SSEQNVHVLN TDLDIYRQGQ INYLPPDQTQ PWVLNASIDF FGSLPSNSSM SIAISETNSG 

       250        260        270        280        290        300 
AELTTQSLRN ITILNGSITG VAVLKDASPK LWWPYGLGEQ NLYNVTITVS DGVRSLARVT 

       310        320        330        340        350        360 
KRTGFRTIFL NQRNITDTEI AQGVAPGAHW NFEVNGHEFY AKGSNLIPPD AFWARVTTTK 

       370        380        390        400        410        420 
MARLFDSVVA ANQNMLRVWS SGAYLPDFMY DLADERGVLL WSEFEFSDAM YPVDKAFLDN 

       430        440        450        460        470        480 
VAAEVVYNVR RVNHHPSLAL WAGGNEIESL ILPTIERSYP DQYAKYVGDY ETLYINLILP 

       490        500        510        520        530        540 
LVYENTHSIT YSPSSTTEGY LDVNLSAKIV MAERYQNLTE GHYYGDTDYY NYDTSVAFDF 

       550        560        570        580        590        600 
SQYPVGRFAN EFGFHSMPSL QSWQQAVDPE DLHFNSSVIM LRNHHYPAGN LSTHNFHNTS 

       610        620        630        640        650        660 
MGMGETTMGV MNYYPVPDKT DPIANFSAWC HATQLFQADF YKSQIQFYRR GSGMPERQLG 

       670        680        690        700        710        720 
SLYWQLEDIW QAPSWAGIEY DGRWKVLHYV ARDIYQPVIV SPFWNSTTRR LDVYVTSDLW 

       730        740        750        760        770        780 
EPVSGTVDLA WMDLSGKPIA QNARTPKTAA FVVGALNTTK IYSMNINERA LPDPKNSVLI 


FPG

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH476602 Genomic DNA. Translation: EAU33180.1.
RefSeqXP_001215814.1. XM_001215814.1.

3D structure databases

ProteinModelPortalQ0CI48.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00009356; CADATEAP00009356; CADATEAG00009356.
GeneID4321960.

Phylogenomic databases

eggNOGCOG3250.
HOGENOMHOG000216059.
OrthoDBEOG47DDQ6.

Enzyme and pathway databases

UniPathwayUPA00280.

Family and domain databases

Gene3D2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProIPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMSSF49303. Glyco_hydro_2Ig. 2 hits.
SSF51445. Glyco_hydro_cat. 1 hit.
PROSITEPS00719. GLYCOSYL_HYDROL_F2_1. False negative.
PS00608. GLYCOSYL_HYDROL_F2_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANBA_ASPTN
AccessionPrimary (citable) accession number: Q0CI48
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 17, 2006
Last modified: May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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