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Q0CI48

- MANBA_ASPTN

UniProt

Q0CI48 - MANBA_ASPTN

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Protein
Beta-mannosidase A
Gene
mndA, ATEG_06636
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei480 – 4801Proton donor By similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:ATEG_06636
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 932913Beta-mannosidase A
PRO_0000394648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi289 – 2891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi551 – 5511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi609 – 6091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi624 – 6241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi632 – 6321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi659 – 6591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi739 – 7391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi791 – 7911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi33178.CADATEAP00009356.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000216059.
OMAiCHATQLF.
OrthoDBiEOG78D7TH.

Family and domain databases

InterProiIPR006102. Glyco_hydro_2_Ig-like.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CI48-1 [UniParc]FASTAAdd to Basket

« Hide

MRVPAQATIA VLASAVSSPL NDPQIYDLGK LGWTLSSPAL NRTVPGHLPS    50
QVHLDLLRAG VIDDPYHDLN DFNLRWIADA NWTYTSDPIR GLGNNTHSTW 100
LVFEGLDTFA TIKYCDKQIA STNNQFRQYA FDISEAVKDC TADPVLSLNF 150
GSAPKIVDQI AADPASPQWP FGIQQSYEYP NRWFMRKEQS DFGWDWGPAF 200
APAGPWKPAY LVQLSSEQNV HVLNTDLDIY RQGQINYLPP DQTQPWVLNA 250
SIDFFGSLPS NSSMSIAISE TNSGAELTTQ SLRNITILNG SITGVAVLKD 300
ASPKLWWPYG LGEQNLYNVT ITVSDGVRSL ARVTKRTGFR TIFLNQRNIT 350
DTEIAQGVAP GAHWNFEVNG HEFYAKGSNL IPPDAFWARV TTTKMARLFD 400
SVVAANQNML RVWSSGAYLP DFMYDLADER GVLLWSEFEF SDAMYPVDKA 450
FLDNVAAEVV YNVRRVNHHP SLALWAGGNE IESLILPTIE RSYPDQYAKY 500
VGDYETLYIN LILPLVYENT HSITYSPSST TEGYLDVNLS AKIVMAERYQ 550
NLTEGHYYGD TDYYNYDTSV AFDFSQYPVG RFANEFGFHS MPSLQSWQQA 600
VDPEDLHFNS SVIMLRNHHY PAGNLSTHNF HNTSMGMGET TMGVMNYYPV 650
PDKTDPIANF SAWCHATQLF QADFYKSQIQ FYRRGSGMPE RQLGSLYWQL 700
EDIWQAPSWA GIEYDGRWKV LHYVARDIYQ PVIVSPFWNS TTRRLDVYVT 750
SDLWEPVSGT VDLAWMDLSG KPIAQNARTP KTAAFVVGAL NTTKIYSMNI 800
NERALPDPKN SVLILSVQAE GHLPNSNKKS TLTHQGHFTP VFPKDLMLVD 850
PHLELRYNAK TLTFTVQAKA GVSLYTWLDY PAGVVGYFED NGFVLVPGQK 900
RDIRFVMQED KTDGNWVQDV TVRSLWDQTT KT 932
Length:932
Mass (Da):105,189
Last modified:March 19, 2014 - v2
Checksum:i2B1436F3E4E53D88
GO

Sequence cautioni

The sequence EAU33180.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33180.1. Sequence problems.
RefSeqiXP_001215814.1. XM_001215814.1.

Genome annotation databases

EnsemblFungiiCADATEAT00009356; CADATEAP00009356; CADATEAG00009356.
GeneIDi4321960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33180.1 . Sequence problems.
RefSeqi XP_001215814.1. XM_001215814.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00009356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00009356 ; CADATEAP00009356 ; CADATEAG00009356 .
GeneIDi 4321960.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000216059.
OMAi CHATQLF.
OrthoDBi EOG78D7TH.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

InterProi IPR006102. Glyco_hydro_2_Ig-like.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.
  2. "Phylogenetic analysis and substrate specificity of GH2 beta-mannosidases from Aspergillus species."
    Reddy S.K., Rosengren A., Klaubauf S., Kulkarni T., Karlsson E.N., de Vries R.P., Stalbrand H.
    FEBS Lett. 587:3444-3449(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE MODEL REVISION.

Entry informationi

Entry nameiMANBA_ASPTN
AccessioniPrimary (citable) accession number: Q0CI48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 19, 2014
Last modified: July 9, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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