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Q0CI48

- MANBA_ASPTN

UniProt

Q0CI48 - MANBA_ASPTN

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Protein

Beta-mannosidase A

Gene

mndA

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei480 – 4801Proton donorBy similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:ATEG_06636
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 932913Beta-mannosidase APRO_0000394648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi551 – 5511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi739 – 7391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi33178.CADATEAP00009356.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000216059.
OMAiCHATQLF.
OrthoDBiEOG78D7TH.

Family and domain databases

InterProiIPR006102. Glyco_hydro_2_Ig-like.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CI48 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVPAQATIA VLASAVSSPL NDPQIYDLGK LGWTLSSPAL NRTVPGHLPS
60 70 80 90 100
QVHLDLLRAG VIDDPYHDLN DFNLRWIADA NWTYTSDPIR GLGNNTHSTW
110 120 130 140 150
LVFEGLDTFA TIKYCDKQIA STNNQFRQYA FDISEAVKDC TADPVLSLNF
160 170 180 190 200
GSAPKIVDQI AADPASPQWP FGIQQSYEYP NRWFMRKEQS DFGWDWGPAF
210 220 230 240 250
APAGPWKPAY LVQLSSEQNV HVLNTDLDIY RQGQINYLPP DQTQPWVLNA
260 270 280 290 300
SIDFFGSLPS NSSMSIAISE TNSGAELTTQ SLRNITILNG SITGVAVLKD
310 320 330 340 350
ASPKLWWPYG LGEQNLYNVT ITVSDGVRSL ARVTKRTGFR TIFLNQRNIT
360 370 380 390 400
DTEIAQGVAP GAHWNFEVNG HEFYAKGSNL IPPDAFWARV TTTKMARLFD
410 420 430 440 450
SVVAANQNML RVWSSGAYLP DFMYDLADER GVLLWSEFEF SDAMYPVDKA
460 470 480 490 500
FLDNVAAEVV YNVRRVNHHP SLALWAGGNE IESLILPTIE RSYPDQYAKY
510 520 530 540 550
VGDYETLYIN LILPLVYENT HSITYSPSST TEGYLDVNLS AKIVMAERYQ
560 570 580 590 600
NLTEGHYYGD TDYYNYDTSV AFDFSQYPVG RFANEFGFHS MPSLQSWQQA
610 620 630 640 650
VDPEDLHFNS SVIMLRNHHY PAGNLSTHNF HNTSMGMGET TMGVMNYYPV
660 670 680 690 700
PDKTDPIANF SAWCHATQLF QADFYKSQIQ FYRRGSGMPE RQLGSLYWQL
710 720 730 740 750
EDIWQAPSWA GIEYDGRWKV LHYVARDIYQ PVIVSPFWNS TTRRLDVYVT
760 770 780 790 800
SDLWEPVSGT VDLAWMDLSG KPIAQNARTP KTAAFVVGAL NTTKIYSMNI
810 820 830 840 850
NERALPDPKN SVLILSVQAE GHLPNSNKKS TLTHQGHFTP VFPKDLMLVD
860 870 880 890 900
PHLELRYNAK TLTFTVQAKA GVSLYTWLDY PAGVVGYFED NGFVLVPGQK
910 920 930
RDIRFVMQED KTDGNWVQDV TVRSLWDQTT KT
Length:932
Mass (Da):105,189
Last modified:March 19, 2014 - v2
Checksum:i2B1436F3E4E53D88
GO

Sequence cautioni

The sequence EAU33180.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33180.1. Sequence problems.
RefSeqiXP_001215814.1. XM_001215814.1.

Genome annotation databases

EnsemblFungiiCADATEAT00009356; CADATEAP00009356; CADATEAG00009356.
GeneIDi4321960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476602 Genomic DNA. Translation: EAU33180.1 . Sequence problems.
RefSeqi XP_001215814.1. XM_001215814.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00009356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00009356 ; CADATEAP00009356 ; CADATEAG00009356 .
GeneIDi 4321960.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000216059.
OMAi CHATQLF.
OrthoDBi EOG78D7TH.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

InterProi IPR006102. Glyco_hydro_2_Ig-like.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.
  2. "Phylogenetic analysis and substrate specificity of GH2 beta-mannosidases from Aspergillus species."
    Reddy S.K., Rosengren A., Klaubauf S., Kulkarni T., Karlsson E.N., de Vries R.P., Stalbrand H.
    FEBS Lett. 587:3444-3449(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE MODEL REVISION.

Entry informationi

Entry nameiMANBA_ASPTN
AccessioniPrimary (citable) accession number: Q0CI48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 19, 2014
Last modified: October 29, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3