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Protein

Riboflavin kinase

Gene

fmn1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.By similarity

Catalytic activityi

ATP + riboflavin = ADP + FMN.

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Zinc or magnesium.By similarity

Pathway:iFMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin kinase (fmn1)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Magnesium or zincBy similarity
Active sitei104 – 1041NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
Flavin mononucleotide kinase 1
Gene namesi
Name:fmn1
ORF Names:ATEG_06773
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_06773.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Riboflavin kinasePRO_0000301837Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ0CHR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the flavokinase family.Curated

Phylogenomic databases

eggNOGiCOG0196.
HOGENOMiHOG000260803.
OMAiFHKLPDF.
OrthoDBiEOG7K3V05.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
InterProiIPR023468. Riboflavin_kinase.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF01687. Flavokinase. 1 hit.
[Graphical view]
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0CHR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPDTSRDPV AGPDSGPEPP FPIRLAGPVI KGFGRGSKEL GIPTANIPAD
60 70 80 90 100
GLAEYPDLQV GVYYGVVALN PAQSEVPSTS AQILPAVLSI GYNPFYKNTT
110 120 130 140 150
RSIEIHIMPP LTAPSPTATG TPGHVTFHKL PDFYGTSLKL LILGYIRPEY
160 170 180 190 200
DYVSAEALIE DIRVDCEVAR RSLQRGAYVR YLGAGADENE ENEEVQEQRR

WLTTF
Length:205
Mass (Da):22,385
Last modified:October 17, 2006 - v1
Checksum:i655D3733D10B2371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33317.1.
RefSeqiXP_001215951.1. XM_001215951.1.

Genome annotation databases

EnsemblFungiiCADATEAT00009371; CADATEAP00009371; CADATEAG00009371.
GeneIDi4321940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476602 Genomic DNA. Translation: EAU33317.1.
RefSeqiXP_001215951.1. XM_001215951.1.

3D structure databases

ProteinModelPortaliQ0CHR1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00009371; CADATEAP00009371; CADATEAG00009371.
GeneIDi4321940.

Organism-specific databases

EuPathDBiFungiDB:ATEG_06773.

Phylogenomic databases

eggNOGiCOG0196.
HOGENOMiHOG000260803.
OMAiFHKLPDF.
OrthoDBiEOG7K3V05.

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
InterProiIPR023468. Riboflavin_kinase.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF01687. Flavokinase. 1 hit.
[Graphical view]
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiRIFK_ASPTN
AccessioniPrimary (citable) accession number: Q0CHR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.