Q0CFZ0 (AMPP3_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase pepP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	pepP
ORF Names:	ATEG_06859

Organism

Aspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus terreus

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Probable Xaa-Pro aminopeptidase pepP		PRO_0000411867
Sites
	Metal binding	264	1	Manganese 2 By similarity
	Metal binding	275	1	Manganese 1 By similarity
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	398	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0CFZ0 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 33A03A2617A0496D	FASTA	466	51,859
	10 20 30 40 50 60 MATVDTILQG KYPAKAHARR VAEYLQAQCP GNPGVIYLES QKTRMIEDND ETMPFRQRRP 70 80 90 100 110 120 FFYLSGCLLP EASLVYDVSA DKLTLFIPAI DPEDVIWSGL PLSPSEAMEL YDVDNVLTTP 130 140 150 160 170 180 EVNATLASIA SAHNGKAVAY AIQGRTSPET KFEGFQDANF TLLNGWIEQA RVVKDAYEIA 190 200 210 220 230 240 LLRKANDIST KAHIAAIKAA KTATNEREIE GAFIATCIAN GAREQSYHPI VACGENGATL 250 260 270 280 290 300 HYPKNDAELT DPVTKQRKKN VLIDAGGEYR TYCADITRVI PLGGRFAQET RQIYQIVLQM 310 320 330 340 350 360 QLECIAMLKD GVLWDDVHAH AHRVAIKGLL QLGILRGSED ELFEKRVSVA FFPHGLGHYL 370 380 390 400 410 420 GMDTHDTGGN PNYGDKDKMF RYLRVRGHLP AGSVITVEPG IYFCRFIIEP YIKSPETSKY 430 440 450 460 IDTDVLERYW SVGGVRIEDN VHVTKDGYEN LTTAPKIMEE VESLAL

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIH 2624 / FGSC A1156.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476603 Genomic DNA. Translation: EAU32243.1.
RefSeq	XP_001209544.1. XM_001209544.1.
3D structure databases
ProteinModelPortal	Q0CFZ0.
ModBase	Search...
Protein-protein interaction databases
STRING	33178.CADATEAP00001671.
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADATEAT00001671; CADATEAP00001671; CADATEAG00001671.
GeneID	4318863.
Phylogenomic databases
HOGENOM	HOG000008763.
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_ASPTN

Accession

Primary (citable) accession number: Q0CFZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	October 17, 2006
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program