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Protein

Probable beta-glucosidase btgE

Gene

btgE

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei495 – 4951NucleophileBy similarity
Active sitei549 – 5491Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase btgE (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase btgE
Cellobiase btgE
Gentiobiase btgE
Gene namesi
Name:btgE
ORF Names:ATEG_07755
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_07755.

Subcellular locationi

  • Secretedcell wall By similarity

  • Note: Covalently-linked to the cell wall.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 558540Probable beta-glucosidase btgEPRO_0000395135Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00001314.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 281238Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000158427.
OMAiYSTDCDT.
OrthoDBiEOG73FQWG.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CEX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAILATAA ALTGSALADV AHMRRGHDSF HHRRAMHAQE PEETCGCTTE
60 70 80 90 100
VITFYGSPTL VPISTPSATP TPAPAPETTS TEEVTTTLHS TSTSTVTVTA
110 120 130 140 150
TPETPEVTLP TPGVTSFSST GVYTIPATTL TVTDTTTVCG ATSTELPSGT
160 170 180 190 200
ATYGGVTTVV ETSTTVVCPY ATVKPSGSTV TSVIETTTYV CPSAGTYTVV
210 220 230 240 250
PPTTTYVPTS TVMVYPTPAT FTPGTYTQDA QTVTVTRTDY TYVCPTFHPE
260 270 280 290 300
LPSSSAPAPT TSAVPTTTAV PTSTVVPSST TSVPASSSSS SAEVPQTTGS
310 320 330 340 350
GQMGMTYSPY TNAGGCKSKA DVLQDIATIK QKGFTHVRVY STDCSSLEWI
360 370 380 390 400
GEGAKQQGLI MILGVYIDSS GVSGAQSQVT DIANWAEWDL VSLIVVGNEA
410 420 430 440 450
IQNGYCTASE LASFITSAKQ AFKAAGYSGQ VTTTEPINVW ESSGSALCSS
460 470 480 490 500
IDILGANIHP FFNSEVTASQ AGKFVQSQVD ILEKICPGKD VINLETGWPS
510 520 530 540 550
KGSANGLAIP GTSQQSEAIK SLRNDVGALS VFFSFSNDLW KSPGAFDVEQ

YWGCIDQF
Length:558
Mass (Da):58,036
Last modified:October 17, 2006 - v1
Checksum:i6192971E1E0EFE0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476604 Genomic DNA. Translation: EAU32017.1.
RefSeqiXP_001216376.1. XM_001216376.1.

Genome annotation databases

EnsemblFungiiCADATEAT00001314; CADATEAP00001314; CADATEAG00001314.
GeneIDi4322886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476604 Genomic DNA. Translation: EAU32017.1.
RefSeqiXP_001216376.1. XM_001216376.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi33178.CADATEAP00001314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00001314; CADATEAP00001314; CADATEAG00001314.
GeneIDi4322886.

Organism-specific databases

EuPathDBiFungiDB:ATEG_07755.

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000158427.
OMAiYSTDCDT.
OrthoDBiEOG73FQWG.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiBTGE_ASPTN
AccessioniPrimary (citable) accession number: Q0CEX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 17, 2006
Last modified: April 29, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.