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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

tpc1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:tpc1
ORF Names:ATEG_07845
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_07845.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 35Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei91 – 107Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei125 – 145Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei180 – 197Helical; Name=4Sequence analysisAdd BLAST18
Transmembranei219 – 239Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei283 – 300Helical; Name=6Sequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204581 – 320Mitochondrial thiamine pyrophosphate carrier 1Add BLAST320

Structurei

3D structure databases

ProteinModelPortaliQ0CEN9.
SMRiQ0CEN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 110Solcar 1Add BLAST99
Repeati119 – 205Solcar 2Add BLAST87
Repeati213 – 308Solcar 3Add BLAST96

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165726.
OMAiWKGNVPA.
OrthoDBiEOG092C3KDM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q0CEN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGEHLKD EGTRRQVVLA GGIAGLVSRF CVAPLDVVKI RLQLQIHSLS
60 70 80 90 100
DPSSHRNVSG PIYKGTISTM RAIIREEGIT GLWKGNIPAE LMYVCYGGVQ
110 120 130 140 150
FTTYRTTTQA LAQLPHRLPQ PVESFVAGAS AGGLATAATY PLDLLRTRFA
160 170 180 190 200
AQGTERVYTS LLASVRDIAR IEGPAGFFRG CSAAVGQIVP YMGLFFATYE
210 220 230 240 250
SLRPSLATVQ DLPFGSGDAL AGMIASVLAK TGVFPLDLVR KRLQVQGPTR
260 270 280 290 300
SRYIHRNIPE YRGVFNTLAL ILRTQGVRGL YRGLTVSLFK AAPASAVTMW
310 320
TYEETLRALQ AMEVAAQKDE
Length:320
Mass (Da):34,635
Last modified:October 17, 2006 - v1
Checksum:i69C5CC3B23B6BD58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476604 Genomic DNA. Translation: EAU32107.1.
RefSeqiXP_001216466.1. XM_001216466.1.

Genome annotation databases

EnsemblFungiiCADATEAT00001323; CADATEAP00001323; CADATEAG00001323.
GeneIDi4323017.

Similar proteinsi

Entry informationi

Entry nameiTPC1_ASPTN
AccessioniPrimary (citable) accession number: Q0CEN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 17, 2006
Last modified: June 7, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families