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Protein

Probable alpha-L-arabinofuranosidase B

Gene

abfB

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Able to hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.

Pathway: L-arabinan degradation

This protein is involved in the pathway L-arabinan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway L-arabinan degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei184 – 1852Cis-peptide bondBy similarity
Binding sitei227 – 2271SubstrateBy similarity
Active sitei229 – 2291NucleophileBy similarity
Binding sitei230 – 2301Substrate; via amide nitrogenBy similarity
Binding sitei304 – 3041Substrate; via amide nitrogenBy similarity
Active sitei305 – 3051Proton donorBy similarity
Binding sitei424 – 4241SubstrateBy similarity
Binding sitei427 – 4271Substrate; via amide nitrogenBy similarity
Binding sitei443 – 4431SubstrateBy similarity
Binding sitei471 – 4711SubstrateBy similarity
Binding sitei476 – 4761Substrate; via amide nitrogenBy similarity
Binding sitei496 – 4961SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00667.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-L-arabinofuranosidase B (EC:3.2.1.55)
Short name:
ABF B
Short name:
Arabinosidase B
Gene namesi
Name:abfB
ORF Names:ATEG_07939
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_07939.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 506480Probable alpha-L-arabinofuranosidase BPRO_0000394608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 39By similarity
Disulfide bondi89 ↔ 94By similarity
Disulfide bondi184 ↔ 185By similarity
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi409 ↔ 447By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0CEE5.
SMRiQ0CEE5. Positions 27-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 343317CatalyticBy similarityAdd
BLAST
Regioni344 – 506163ABDBy similarityAdd
BLAST

Domaini

Organized into two domains: an N-terminal catalytic domain and a C-terminal arabinose-binding domain (ABD).By similarity

Sequence similaritiesi

Belongs to the glycosyl hydrolase 54 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG83819.
HOGENOMiHOG000187007.
OMAiNIVAAKY.
OrthoDBiEOG7DFXNQ.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR015289. A-L-arabinofuranosidase_B_cat.
IPR007934. AbfB_ABD.
IPR013320. ConA-like_dom.
[Graphical view]
PfamiPF05270. AbfB. 1 hit.
PF09206. ArabFuran-catal. 1 hit.
[Graphical view]
SUPFAMiSSF110221. SSF110221. 1 hit.
SSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CEE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPRGFNRA VVTALGVVGT GTLVAAGPCD IYSSGGTPCV AAHSTTRALY
60 70 80 90 100
SAYTGPLYQV KRGSDGATTN IAPLSAGGVA NAAAQDSFCA GTTCLITIIY
110 120 130 140 150
DQSGRGNHLT QAPPGGFKGP EANGYDNLAS AIGAPVTLNG QKAYGVFISP
160 170 180 190 200
GTGYRNNAAS GTATGDAPEG MYAVLDGTHY NGGCCFDYGN AETSSTDTGN
210 220 230 240 250
GHMEAIYFGD NTVWGSGSGS GPWIMADLEN GLFSGSSTKN NAGDPSVSYR
260 270 280 290 300
FLTAIVKGKP NQWAIRGANA ASGSLSTYYN GARPNASGYN PMSKEGAIIL
310 320 330 340 350
GIGGDNSIGA QGTFYEGVMT SGYPSDATEN SVQANIVAAK YAVAPLTSGP
360 370 380 390 400
SLTVGSSISL RATTSCCTTR YLAHNGSTVN TQVVSSSSST ALKQQASWTV
410 420 430 440 450
RAGLANSACF SFESKDTPGS FIRHYDFVLQ LSANDGTKQF YEDATFCPQS
460 470 480 490 500
GLNGQGSSIR SWNYPTRYFR HYNNVLYAAS NGGVHTFDAT GSFNDDVSWV

VSTSFA
Length:506
Mass (Da):52,197
Last modified:October 17, 2006 - v1
Checksum:i10913205A0B91DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476604 Genomic DNA. Translation: EAU32201.1.
RefSeqiXP_001216560.1. XM_001216560.1.

Genome annotation databases

EnsemblFungiiCADATEAT00002379; CADATEAP00002379; CADATEAG00002379.
GeneIDi4322793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476604 Genomic DNA. Translation: EAU32201.1.
RefSeqiXP_001216560.1. XM_001216560.1.

3D structure databases

ProteinModelPortaliQ0CEE5.
SMRiQ0CEE5. Positions 27-506.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00002379; CADATEAP00002379; CADATEAG00002379.
GeneIDi4322793.

Organism-specific databases

EuPathDBiFungiDB:ATEG_07939.

Phylogenomic databases

eggNOGiNOG83819.
HOGENOMiHOG000187007.
OMAiNIVAAKY.
OrthoDBiEOG7DFXNQ.

Enzyme and pathway databases

UniPathwayiUPA00667.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR015289. A-L-arabinofuranosidase_B_cat.
IPR007934. AbfB_ABD.
IPR013320. ConA-like_dom.
[Graphical view]
PfamiPF05270. AbfB. 1 hit.
PF09206. ArabFuran-catal. 1 hit.
[Graphical view]
SUPFAMiSSF110221. SSF110221. 1 hit.
SSF49899. SSF49899. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiABFB_ASPTN
AccessioniPrimary (citable) accession number: Q0CEE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 17, 2006
Last modified: June 24, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.