Q0CDB3 (AMPP1_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	ampp
ORF Names:	ATEG_08321

Organism

Aspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]

Taxonomic identifier

341663 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus terreus

Protein attributes

Sequence length	654 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 654	654	Probable Xaa-Pro aminopeptidase P		PRO_0000411784
Sites
	Metal binding	449	1	Manganese 2 By similarity
	Metal binding	460	1	Manganese 1 By similarity
	Metal binding	460	1	Manganese 2 By similarity
	Metal binding	558	1	Manganese 1 By similarity
	Metal binding	572	1	Manganese 1 By similarity
	Metal binding	572	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0CDB3 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: B70CCB470E934A7F	FASTA	654	72,744
	10 20 30 40 50 60 MLFSHPPIRL AWSSAFRSAR QLPLSRPRFF SISVPRYAVD METVDTTERL SRLRQLMKDH 70 80 90 100 110 120 QVDVYIVPSE DSHQSEYIAP CDGRREFISG FSGSAGTAIV SLTKAALSTD GRYFNQASKQ 130 140 150 160 170 180 LDSNWVLLKR GVEGVQTWQE WTTEQAEGGK VVGVDPALIT ASGARSLSET LQKNGSSLKG 190 200 210 220 230 240 IRPNLVDLVW GNDRPSPPRE KVTVHPEKFA GKSFQDKISE LRKELEKKKT AGFVISMLDE 250 260 270 280 290 300 IAWLFNLRGT DIPYNPVFFS YAIITPTTAE LYVDDDKLTP EVKAHLGQDV VVKPYDSIYA 310 320 330 340 350 360 DAEALSAARK QDAGDAAPKF LLSNKASWAL SLSLGGEEQT EEVRSPIADA KAVKNDVELS 370 380 390 400 410 420 GMRACHIRDG AALIEYFAWL ENELVNKKTT LDEVDAADKL EQIRSKHELF AGLSFDTISS 430 440 450 460 470 480 TGPNGAVIHY KPEKGSCSII DPNAIYLCDS GAQFLDGTTD VTRTFHFGKP TELEKKAFTL 490 500 510 520 530 540 VLKGMIALDS AVFPKGTSGF ALDVLARQYL WQEGLDYLHG TGHGIGSYLN VHEGPMGIGT 550 560 570 580 590 600 RVQYTEVPIA PGNVISNEPG FYEDGKFGIR IENVIMAREV QTPHKFGDRP WLGFEHVTMA 610 620 630 640 650 PIGLNLIEPS LLSDSEIKWV NDYHAEVWEK THHFFQNDER TRSWLQRETQ PISK

References

[1]

"Annotation of the Aspergillus terreus NIH2624 genome." Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NIH 2624 / FGSC A1156.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476605 Genomic DNA. Translation: EAU31494.1.
RefSeq	XP_001216942.1. XM_001216942.1.
3D structure databases
ProteinModelPortal	Q0CDB3.
ModBase	Search...
Protein-protein interaction databases
STRING	33178.CADATEAP00004725.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADATEAT00004725; CADATEAP00004725; CADATEAG00004725.
GeneID	4353118.
Phylogenomic databases
HOGENOM	HOG000255713.
OrthoDB	EOG45F0XX.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_ASPTN

Accession

Primary (citable) accession number: Q0CDB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	October 17, 2006
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program