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Protein

Catalase-peroxidase

Gene

katG

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei86 – 861Transition state stabilizerUniRule annotation
Active sitei90 – 901Proton acceptorUniRule annotation
Metal bindingi260 – 2601Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3413. AteCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:ATEG_08422
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_08422.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Catalase-peroxidasePRO_0000354103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki89 ↔ 219Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-245)UniRule annotation
Cross-linki219 ↔ 245Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-89)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ0CD12.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ0CD12.
SMRiQ0CD12. Positions 14-728.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
OMAiTESKCPF.
OrthoDBiEOG7BKD32.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0CD12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGESKCPVNF AGGGTRNKDW WPDQLRLNIL RQHTSASNPL DADFDYAAAF
60 70 80 90 100
NSLDYNALKK DLEALMTDSQ DWWPADFGHY GGLFIRMAWH SAGTYRVFDG
110 120 130 140 150
RGGAGQGQQR FAPLNSWPDN ASLDKARRLL WPIKQKYGNK ISWADLMILA
160 170 180 190 200
GNVALESMGF KPFGFSGGRA DTWEADESVY WGGEKTWFPK GNDVRYPNDD
210 220 230 240 250
IYTRDLENPL AASHMGLIYV NPEGPNGNPD PKAAARDIRV TFGRMAMNDE
260 270 280 290 300
ETVALIAGGH SFGKTHGASS GDHCGPEPEA AGLEAQGLGW QSKYGSGSGR
310 320 330 340 350
DAITSGLEVT WTKTPTRWST NFLEYLFAFD WELTKSPAGA NQWVAKNADA
360 370 380 390 400
IIPDAFDPSK KHKPQMLTTD LALRYDPAYE KIARRFLENP DQFADAFARA
410 420 430 440 450
WFKLTHRDMG PRARYVGPEV PSEVLIWQDP IPAVNHPLVD ASDIASLKQA
460 470 480 490 500
ILNSGVDRSK FVSTAWAAAS TFRGGDKRGG ANGARIRLAP QRDWEVNNQP
510 520 530 540 550
WLKESLAALE KIQSSFNGSR SDRKKISLAD LIVLAGCAAV ESAAQEAGHA
560 570 580 590 600
VSVPFTPGRM DASQEETDVE SFSHMEPVAD GFRNYSTAPT RRRAEHYLVD
610 620 630 640 650
KAQMLTLSAP EMTALVGGLR ALNANYDGSA HGVFTSRPGY LTNDFFVNLL
660 670 680 690 700
DMGTTWKPTD ASGELYEGAD RRTGSKKWTA TRVDLVFGSH AELRAIAEVY
710 720 730
GSSDGERKFV KDFVAAWNKV MNLDRFDLKR ENVPARL
Length:737
Mass (Da):81,333
Last modified:October 17, 2006 - v1
Checksum:i59F5B80D7B3F9425
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476605 Genomic DNA. Translation: EAU31595.1.
RefSeqiXP_001217043.1. XM_001217043.1.

Genome annotation databases

EnsemblFungiiCADATEAT00005560; CADATEAP00005560; CADATEAG00005560.
GeneIDi4353293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476605 Genomic DNA. Translation: EAU31595.1.
RefSeqiXP_001217043.1. XM_001217043.1.

3D structure databases

ProteinModelPortaliQ0CD12.
SMRiQ0CD12. Positions 14-728.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3413. AteCP01.

Proteomic databases

PRIDEiQ0CD12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00005560; CADATEAP00005560; CADATEAG00005560.
GeneIDi4353293.

Organism-specific databases

EuPathDBiFungiDB:ATEG_08422.

Phylogenomic databases

HOGENOMiHOG000218110.
OMAiTESKCPF.
OrthoDBiEOG7BKD32.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiKATG_ASPTN
AccessioniPrimary (citable) accession number: Q0CD12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.