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Q0CCR9

- KEX1_ASPTN

UniProt

Q0CCR9 - KEX1_ASPTN

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901By similarity
    Active sitei389 – 3891By similarity
    Active sitei451 – 4511By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:kex1
    ORF Names:ATEG_08515
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 625587Pheromone-processing carboxypeptidase kex1PRO_0000411906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00007888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CCR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 522484LumenalSequence AnalysisAdd
    BLAST
    Topological domaini544 – 62582CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000208879.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0CCR9-1 [UniParc]FASTAAdd to Basket

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    MVSLSLRGAR RTAKDAASLP FLSWTLSLLA LNPLLVSAKS AADYYVRSLP    50
    GAPEGPLLKM HAGHIEVDPE NHGNLFFWHF QNRHIANRQR TVIWLNGGPG 100
    CSSMDGALME VGPYRLKDNS TLEYNEGSWD EFGNLLFVDQ PVGTGFSYVN 150
    GNQYLHEMDE MAAHFITFLE NWFDIFPEYE RDDIYIAGES FAGQHIPYIA 200
    KAIQERNEKA QMKPKWSLRG LLIGNGWISP KDQYPSYLTF AYEEGLITKD 250
    SRTAKNLEVL QSVCESRLEA GKNKIHLDDC EKVLSEMLTK TMDVSKNECI 300
    NSYDIRLRDE APACGMNWPP ELTHMNYYLR QPELISALNI NPEKKSGWME 350
    CSNAVSSTFR TQKSVPSVQL LPGLIESGIP ILLFSGDKDL ICNHVGTEEL 400
    INNMKWNGGT GFETSPGVWA PRHDWTFEGE PAGIYQYARN LTYVLFYNAS 450
    HMVPYDLPRQ SRDMLDRFMQ VDIASIGGSP ADSRIDGEKL PQTSVGGHPN 500
    STAAEEQEKK KMKEAEWKAY AKSGEAVLVV VIIGVIVWGF FIWRSRRHHR 550
    GYRSVYNKNM SGSSVLERFH SKRSGADMEA GDFDEAELDD LHSPGLDREH 600
    YAVGDDSDDE QQHQRQGSRP EGGQS 625
    Length:625
    Mass (Da):70,454
    Last modified:October 17, 2006 - v1
    Checksum:i3FC518DD043A26D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476606 Genomic DNA. Translation: EAU30647.1.
    RefSeqiXP_001217101.1. XM_001217100.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00007888; CADATEAP00007888; CADATEAG00007888.
    GeneIDi4323538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476606 Genomic DNA. Translation: EAU30647.1 .
    RefSeqi XP_001217101.1. XM_001217100.1.

    3D structure databases

    ProteinModelPortali Q0CCR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00007888.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00007888 ; CADATEAP00007888 ; CADATEAG00007888 .
    GeneIDi 4323538.

    Phylogenomic databases

    HOGENOMi HOG000208879.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiKEX1_ASPTN
    AccessioniPrimary (citable) accession number: Q0CCR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3