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Q0CCR9 (KEX1_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:ATEG_08515
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length625 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 625587Pheromone-processing carboxypeptidase kex1
PRO_0000411906

Regions

Topological domain39 – 522484Lumenal Potential
Transmembrane523 – 54321Helical; Potential
Topological domain544 – 62582Cytoplasmic Potential

Sites

Active site1901 By similarity
Active site3891 By similarity
Active site4511 By similarity

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation4401N-linked (GlcNAc...) Potential
Glycosylation4481N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0CCR9 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 3FC518DD043A26D0

FASTA62570,454
        10         20         30         40         50         60 
MVSLSLRGAR RTAKDAASLP FLSWTLSLLA LNPLLVSAKS AADYYVRSLP GAPEGPLLKM 

        70         80         90        100        110        120 
HAGHIEVDPE NHGNLFFWHF QNRHIANRQR TVIWLNGGPG CSSMDGALME VGPYRLKDNS 

       130        140        150        160        170        180 
TLEYNEGSWD EFGNLLFVDQ PVGTGFSYVN GNQYLHEMDE MAAHFITFLE NWFDIFPEYE 

       190        200        210        220        230        240 
RDDIYIAGES FAGQHIPYIA KAIQERNEKA QMKPKWSLRG LLIGNGWISP KDQYPSYLTF 

       250        260        270        280        290        300 
AYEEGLITKD SRTAKNLEVL QSVCESRLEA GKNKIHLDDC EKVLSEMLTK TMDVSKNECI 

       310        320        330        340        350        360 
NSYDIRLRDE APACGMNWPP ELTHMNYYLR QPELISALNI NPEKKSGWME CSNAVSSTFR 

       370        380        390        400        410        420 
TQKSVPSVQL LPGLIESGIP ILLFSGDKDL ICNHVGTEEL INNMKWNGGT GFETSPGVWA 

       430        440        450        460        470        480 
PRHDWTFEGE PAGIYQYARN LTYVLFYNAS HMVPYDLPRQ SRDMLDRFMQ VDIASIGGSP 

       490        500        510        520        530        540 
ADSRIDGEKL PQTSVGGHPN STAAEEQEKK KMKEAEWKAY AKSGEAVLVV VIIGVIVWGF 

       550        560        570        580        590        600 
FIWRSRRHHR GYRSVYNKNM SGSSVLERFH SKRSGADMEA GDFDEAELDD LHSPGLDREH 

       610        620 
YAVGDDSDDE QQHQRQGSRP EGGQS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476606 Genomic DNA. Translation: EAU30647.1.
RefSeqXP_001217101.1. XM_001217100.1.

3D structure databases

ProteinModelPortalQ0CCR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00007888.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00007888; CADATEAP00007888; CADATEAG00007888.
GeneID4323538.

Phylogenomic databases

HOGENOMHOG000208879.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKEX1_ASPTN
AccessionPrimary (citable) accession number: Q0CCR9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries