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Q0CCR9

- KEX1_ASPTN

UniProt

Q0CCR9 - KEX1_ASPTN

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Protein
Pheromone-processing carboxypeptidase kex1
Gene
kex1, ATEG_08515
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901 By similarity
Active sitei389 – 3891 By similarity
Active sitei451 – 4511 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:ATEG_08515
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 522484Lumenal Reviewed prediction
Add
BLAST
Transmembranei523 – 54321Helical; Reviewed prediction
Add
BLAST
Topological domaini544 – 62582Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838 Reviewed prediction
Add
BLAST
Chaini39 – 625587Pheromone-processing carboxypeptidase kex1
PRO_0000411906Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00007888.

Structurei

3D structure databases

ProteinModelPortaliQ0CCR9.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CCR9-1 [UniParc]FASTAAdd to Basket

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MVSLSLRGAR RTAKDAASLP FLSWTLSLLA LNPLLVSAKS AADYYVRSLP    50
GAPEGPLLKM HAGHIEVDPE NHGNLFFWHF QNRHIANRQR TVIWLNGGPG 100
CSSMDGALME VGPYRLKDNS TLEYNEGSWD EFGNLLFVDQ PVGTGFSYVN 150
GNQYLHEMDE MAAHFITFLE NWFDIFPEYE RDDIYIAGES FAGQHIPYIA 200
KAIQERNEKA QMKPKWSLRG LLIGNGWISP KDQYPSYLTF AYEEGLITKD 250
SRTAKNLEVL QSVCESRLEA GKNKIHLDDC EKVLSEMLTK TMDVSKNECI 300
NSYDIRLRDE APACGMNWPP ELTHMNYYLR QPELISALNI NPEKKSGWME 350
CSNAVSSTFR TQKSVPSVQL LPGLIESGIP ILLFSGDKDL ICNHVGTEEL 400
INNMKWNGGT GFETSPGVWA PRHDWTFEGE PAGIYQYARN LTYVLFYNAS 450
HMVPYDLPRQ SRDMLDRFMQ VDIASIGGSP ADSRIDGEKL PQTSVGGHPN 500
STAAEEQEKK KMKEAEWKAY AKSGEAVLVV VIIGVIVWGF FIWRSRRHHR 550
GYRSVYNKNM SGSSVLERFH SKRSGADMEA GDFDEAELDD LHSPGLDREH 600
YAVGDDSDDE QQHQRQGSRP EGGQS 625
Length:625
Mass (Da):70,454
Last modified:October 17, 2006 - v1
Checksum:i3FC518DD043A26D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476606 Genomic DNA. Translation: EAU30647.1.
RefSeqiXP_001217101.1. XM_001217100.1.

Genome annotation databases

EnsemblFungiiCADATEAT00007888; CADATEAP00007888; CADATEAG00007888.
GeneIDi4323538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476606 Genomic DNA. Translation: EAU30647.1 .
RefSeqi XP_001217101.1. XM_001217100.1.

3D structure databases

ProteinModelPortali Q0CCR9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00007888.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00007888 ; CADATEAP00007888 ; CADATEAG00007888 .
GeneIDi 4323538.

Phylogenomic databases

HOGENOMi HOG000208879.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiKEX1_ASPTN
AccessioniPrimary (citable) accession number: Q0CCR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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