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Q0CCD0

- MANA1_ASPTN

UniProt

Q0CCD0 - MANA1_ASPTN

Protein

Probable mannan endo-1,4-beta-mannosidase A-1

Gene

manA-1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei207 – 2071Proton donorBy similarity
    Active sitei315 – 3151NucleophileBy similarity

    GO - Molecular functioni

    1. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannan endo-1,4-beta-mannosidase A-1 (EC:3.2.1.78)
    Alternative name(s):
    Endo-beta-1,4-mannanase A-1
    Gene namesi
    Name:manA-1
    Synonyms:man1-1
    ORF Names:ATEG_08654
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 388368Probable mannan endo-1,4-beta-mannosidase A-1PRO_0000393703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ0CCD0.
    SMRiQ0CCD0. Positions 39-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3934.
    HOGENOMiHOG000169951.
    OMAiDYGGMAA.
    OrthoDBiEOG7M3J90.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0CCD0-1 [UniParc]FASTAAdd to Basket

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    MKLSPLMALA GLASAQLALA LPQATPSASA TPSPTPGDGS FASTNGLQFV    50
    IDGETGYFAG SNSYWIGFLT NNADVDLVFT HMKEAGLRIL RVWGFNDVNE 100
    KPADGTVWFQ MHADGQSTIN TGADGLQRLD YVVQSAEKHG IKLIVNFVNY 150
    WDDYGGMNAY VQAYGGSDNT DFYASKDMQA AYRAYIKAVV SRYLDSPAIF 200
    AWELANEPRC QGCAPSVLHD WIDSTSQYIK SLDSKHMTCI GDEGFGLDIG 250
    SDGSYPYGYS EGGNFTMSLA LPTIDFGTFH LYPSSWGTNN DWGNGWVASH 300
    GAACKAAGKP CLFEEYGVTS DHCAVEKPWQ MTALNTTGIA ADLYWQYGDQ 350
    LSSGQSPNDG NTIYYGTDEF TCLVTDHIAS IGSRATRK 388
    Length:388
    Mass (Da):41,993
    Last modified:October 17, 2006 - v1
    Checksum:iFE35377CB387E076
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476606 Genomic DNA. Translation: EAU30786.1.
    RefSeqiXP_001217240.1. XM_001217239.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00006136; CADATEAP00006136; CADATEAG00006136.
    GeneIDi4323372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476606 Genomic DNA. Translation: EAU30786.1 .
    RefSeqi XP_001217240.1. XM_001217239.1.

    3D structure databases

    ProteinModelPortali Q0CCD0.
    SMRi Q0CCD0. Positions 39-381.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00006136 ; CADATEAP00006136 ; CADATEAG00006136 .
    GeneIDi 4323372.

    Phylogenomic databases

    eggNOGi COG3934.
    HOGENOMi HOG000169951.
    OMAi DYGGMAA.
    OrthoDBi EOG7M3J90.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiMANA1_ASPTN
    AccessioniPrimary (citable) accession number: Q0CCD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3