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Q0CCD0 (MANA1_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannan endo-1,4-beta-mannosidase A-1

EC=3.2.1.78
Alternative name(s):
Endo-beta-1,4-mannanase A-1
Gene names
Name:manA-1
Synonyms:man1-1
ORF Names:ATEG_08654
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans By similarity.

Catalytic activity

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannan endo-1,4-beta-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 388368Probable mannan endo-1,4-beta-mannosidase A-1
PRO_0000393703

Sites

Active site2071Proton donor By similarity
Active site3151Nucleophile By similarity

Amino acid modifications

Glycosylation2641N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0CCD0 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: FE35377CB387E076

FASTA38841,993
        10         20         30         40         50         60 
MKLSPLMALA GLASAQLALA LPQATPSASA TPSPTPGDGS FASTNGLQFV IDGETGYFAG 

        70         80         90        100        110        120 
SNSYWIGFLT NNADVDLVFT HMKEAGLRIL RVWGFNDVNE KPADGTVWFQ MHADGQSTIN 

       130        140        150        160        170        180 
TGADGLQRLD YVVQSAEKHG IKLIVNFVNY WDDYGGMNAY VQAYGGSDNT DFYASKDMQA 

       190        200        210        220        230        240 
AYRAYIKAVV SRYLDSPAIF AWELANEPRC QGCAPSVLHD WIDSTSQYIK SLDSKHMTCI 

       250        260        270        280        290        300 
GDEGFGLDIG SDGSYPYGYS EGGNFTMSLA LPTIDFGTFH LYPSSWGTNN DWGNGWVASH 

       310        320        330        340        350        360 
GAACKAAGKP CLFEEYGVTS DHCAVEKPWQ MTALNTTGIA ADLYWQYGDQ LSSGQSPNDG 

       370        380 
NTIYYGTDEF TCLVTDHIAS IGSRATRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476606 Genomic DNA. Translation: EAU30786.1.
RefSeqXP_001217240.1. XM_001217239.1.

3D structure databases

ProteinModelPortalQ0CCD0.
SMRQ0CCD0. Positions 39-381.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00006136; CADATEAP00006136; CADATEAG00006136.
GeneID4323372.

Phylogenomic databases

eggNOGCOG3934.
HOGENOMHOG000169951.
OMADYGGMAA.
OrthoDBEOG7M3J90.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANA1_ASPTN
AccessionPrimary (citable) accession number: Q0CCD0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries