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Q0CCD0

- MANA1_ASPTN

UniProt

Q0CCD0 - MANA1_ASPTN

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Protein

Probable mannan endo-1,4-beta-mannosidase A-1

Gene

manA-1

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071Proton donorBy similarity
Active sitei315 – 3151NucleophileBy similarity

GO - Molecular functioni

  1. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannan endo-1,4-beta-mannosidase A-1 (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase A-1
Gene namesi
Name:manA-1
Synonyms:man1-1
ORF Names:ATEG_08654
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 388368Probable mannan endo-1,4-beta-mannosidase A-1PRO_0000393703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0CCD0.
SMRiQ0CCD0. Positions 39-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3934.
HOGENOMiHOG000169951.
OMAiDYGGMAA.
OrthoDBiEOG7M3J90.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0CCD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSPLMALA GLASAQLALA LPQATPSASA TPSPTPGDGS FASTNGLQFV
60 70 80 90 100
IDGETGYFAG SNSYWIGFLT NNADVDLVFT HMKEAGLRIL RVWGFNDVNE
110 120 130 140 150
KPADGTVWFQ MHADGQSTIN TGADGLQRLD YVVQSAEKHG IKLIVNFVNY
160 170 180 190 200
WDDYGGMNAY VQAYGGSDNT DFYASKDMQA AYRAYIKAVV SRYLDSPAIF
210 220 230 240 250
AWELANEPRC QGCAPSVLHD WIDSTSQYIK SLDSKHMTCI GDEGFGLDIG
260 270 280 290 300
SDGSYPYGYS EGGNFTMSLA LPTIDFGTFH LYPSSWGTNN DWGNGWVASH
310 320 330 340 350
GAACKAAGKP CLFEEYGVTS DHCAVEKPWQ MTALNTTGIA ADLYWQYGDQ
360 370 380
LSSGQSPNDG NTIYYGTDEF TCLVTDHIAS IGSRATRK
Length:388
Mass (Da):41,993
Last modified:October 17, 2006 - v1
Checksum:iFE35377CB387E076
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476606 Genomic DNA. Translation: EAU30786.1.
RefSeqiXP_001217240.1. XM_001217239.1.

Genome annotation databases

EnsemblFungiiCADATEAT00006136; CADATEAP00006136; CADATEAG00006136.
GeneIDi4323372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476606 Genomic DNA. Translation: EAU30786.1 .
RefSeqi XP_001217240.1. XM_001217239.1.

3D structure databases

ProteinModelPortali Q0CCD0.
SMRi Q0CCD0. Positions 39-381.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00006136 ; CADATEAP00006136 ; CADATEAG00006136 .
GeneIDi 4323372.

Phylogenomic databases

eggNOGi COG3934.
HOGENOMi HOG000169951.
OMAi DYGGMAA.
OrthoDBi EOG7M3J90.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiMANA1_ASPTN
AccessioniPrimary (citable) accession number: Q0CCD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3