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Reviewed, UniProtKB/Swiss-Prot Q0C8L9 (HMDH_ASPTN)

Last modified February 9, 2010. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-hydroxy-3-methylglutaryl-coenzyme A reductase
      Short name=HMG-CoA reductase
    EC=1.1.1.34
Gene names
ORF Names: ATEG_09965
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

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Protein attributes

Sequence length1048 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis By similarity.

Catalytic activity

(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the HMG-CoA reductase family.

Contains 1 SSD (sterol-sensing) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 104810483-hydroxy-3-methylglutaryl-coenzyme A reductase
PRO_0000283711

Regions

Transmembrane221 – 24121 Potential
Transmembrane251 – 27121 Potential
Transmembrane277 – 29721 Potential
Transmembrane349 – 36921 Potential
Transmembrane378 – 39821 Potential
Transmembrane440 – 46021 Potential
Domain222 – 403182SSD
Region461 – 614154Linker By similarity
Region615 – 1040426Catalytic By similarity

Sites

Active site7291Charge relay system By similarity
Active site8631Charge relay system By similarity
Active site9391Charge relay system By similarity
Active site10351Proton donor By similarity

Amino acid modifications

Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential
Glycosylation5201N-linked (GlcNAc...) Potential
Glycosylation7931N-linked (GlcNAc...) Potential
Glycosylation10391N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q0C8L9-1 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: D7A3A8FF88A42B06

FASTA1,048112,181
        10         20         30         40         50         60 
MDPVVKKPSP GGVQHRVTKG LRAIVGHACR HPIHTLLVTA LTAATTHLHV LEGTYQAAHR 

        70         80         90        100        110        120 
GLAPWAKETP LNVQSFLCGS RTVTLGEASA WRWQIDDRPK VSEDGQSDFH WALVTLDLPG 

       130        140        150        160        170        180 
ASVDASIPFL SNTLSEFLGA EQITPTPDSS PSPDHSALTF RVPYSQLDGF LQAVEIIPSE 

       190        200        210        220        230        240 
KEDDSWRLRS PREEGSPTSL GHWVGSSWLS FLHRVKHAET VDLVIIGLSY LAMNMTVVSL 

       250        260        270        280        290        300 
FRVMRQLGSR FWLATSVLLS GAFAFVLGLG ITTTCDVPVD MLLLFEGIPY LVLTVGFEKP 

       310        320        330        340        350        360 
IQLTRAVLCV SEELRGGWQR PVPNGASSDD SRQSQLIPNI IQLAVDREGW YIVRSYLLEI 

       370        380        390        400        410        420 
GALALGAVLR PNDSLGHFCF LAAWTLLIDA ILLFTFYATI LCVKLEITRI RSPGGLGQVN 

       430        440        450        460        470        480 
AKHPSGIFGH KVKSTNITWW KLLTVGGFVL CHFLQLSPFF YRVMGEYMAN GTLPPTAVSP 

       490        500        510        520        530        540 
FKEAANGLNE IYLTARVEGF ETRVTVLPPL QYALESAGFN ISATKRSTFD GVLDGLESPL 

       550        560        570        580        590        600 
GRLCLMGALV VSLVLNNHLI HAARWHAWPQ ARESAVPDGS SLSVPCSATA PEVCTRPPEE 

       610        620        630        640        650        660 
TEALLKSNQA ESLTDDELVE LCLRGKIAGY SLEKTLERIA AGSSCSVTRL DAFTRAVRIR 

       670        680        690        700        710        720 
RAAVSKTPST QNLCSGLAES LLPYRDYNYE LVHGACCENV VGYLPLPLGV AGPMVIDGQA 

       730        740        750        760        770        780 
LFIPMATTEG VLVASASRGC KAINAGGGAT TMLKGDGMTR GPCLRFPSAQ RAAEAQRWVE 

       790        800        810        820        830        840 
SPLGHEVLAA AFNATSRFAR LQTLTVAQAG IYLYIRFRTT TGDAMGMNMI SKGVEKALEA 

       850        860        870        880        890        900 
MAAEGGFPDM HTVTLSGNFC SDKKSAAINW IGGRGKSVIA EATIPAETVR QVLKTDVDAL 

       910        920        930        940        950        960 
VELNTAKNLV GSAMAGSLGG FNAHASNLVQ AVFLATGQDP AQNVESSSCI TTMKNIDGNL 

       970        980        990       1000       1010       1020 
HIAVSMPSME VGTIGGGTIL EAQGAMLDLL GVRGAHATEP GANARRLARI VAAAVLAGEL 

      1030       1040 
STCAALAAGH LVNAHMQHNR SAGATVKK

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References

[1]"Annotation of the Aspergillus terreus NIH2624 genome."
Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. expand/collapse author list , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W., Nierman W.C., Milne T., Madden K.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH476609 Genomic DNA. Translation: EAU29414.1.
RefSeqXP_001209267.1.

3D structure databases

SMRQ0C8L9. Positions 609-1032.
ModBaseSearch...

Genome annotation databases

GeneID4319611.

Phylogenomic databases

OrthoDBEOG94TQS9.

Family and domain databases

InterProIPR002202. HMG_CoA_Rdtase_cat.
IPR004554. HMG_CoA_Rdtase_I_cat.
IPR009023. HMG_CoA_Rdtase_NAD(P)-bd.
IPR009029. HMG_CoA_Rdtase_sub-bd.
IPR000731. SSD_5TM.
[Graphical view]
Gene3DG3DSA:3.90.770.10. HMG-CoA_red. 1 hit.
PANTHERPTHR10572. HMG-CoA_red. 1 hit.
PfamPF00368. HMG-CoA_red. 1 hit.
[Graphical view]
PRINTSPR00071. HMGCOARDTASE.
TIGRFAMsTIGR00533. HMG_CoA_R_NADP. 1 hit.
PROSITEPS00066. HMG_COA_REDUCTASE_1. 1 hit.
PS00318. HMG_COA_REDUCTASE_2. 1 hit.
PS01192. HMG_COA_REDUCTASE_3. 1 hit.
PS50065. HMG_COA_REDUCTASE_4. 1 hit.
PS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHMDH_ASPTN
AccessionPrimary (citable) accession number: Q0C8L9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 17, 2006
Last modified: February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents