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Protein

Probable mannan endo-1,4-beta-mannosidase C

Gene

manC

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202Proton donorBy similarity1
Active sitei320NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannan endo-1,4-beta-mannosidase C (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase C
Gene namesi
Name:manC
ORF Names:ATEG_09991
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000007963 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ATEG_09991.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000039370921 – 406Probable mannan endo-1,4-beta-mannosidase CAdd BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0C8J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000169951.
OMAiEVVFQRW.
OrthoDBiEOG092C2KMO.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0C8J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLINFEKVLS LALLAGSVSG RKHVPRGFVT TSGMKFQLDG KDFYFAGSNA
60 70 80 90 100
YYFPFNDNQT DVELGLAAAK QAGLTVFRTW GFNDKNATYI EGGLPAYGGE
110 120 130 140 150
GAGTTEVVFQ RWANGTSTID LEPFDKVVNA AKNTGMKLVV ALTNNWADYG
160 170 180 190 200
GMDVYTINLG GQYHDDFYRL PAIKKAYKRY VKEMVTRYRD SPAIMAWELA
210 220 230 240 250
NEPRCGADGV RNLPRSADGC NPEVLTAWID EMSTYIKKLD PHHLVTWGGE
260 270 280 290 300
GGFNIESDDW AYNGADGGDF DNELALPNID FGVFHSYPDW WSKTVSWTNQ
310 320 330 340 350
WIRDHAAAMR TGRKPVVHEE YGWLTPEARL EYLGTVSNIT RLEAVGGWQQ
360 370 380 390 400
ISVSEKMSDM YWQYGYSGYS YGRNHNDGFT IYLDDPEAKE LVYKHAKEVK

KLNRRH
Length:406
Mass (Da):45,768
Last modified:October 17, 2006 - v1
Checksum:i2D17F17F4806AC93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476609 Genomic DNA. Translation: EAU29440.1.
RefSeqiXP_001209293.1. XM_001209293.1.

Genome annotation databases

EnsemblFungiiCADATEAT00001977; CADATEAP00001977; CADATEAG00001977.
GeneIDi4319511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476609 Genomic DNA. Translation: EAU29440.1.
RefSeqiXP_001209293.1. XM_001209293.1.

3D structure databases

ProteinModelPortaliQ0C8J3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADATEAT00001977; CADATEAP00001977; CADATEAG00001977.
GeneIDi4319511.

Organism-specific databases

EuPathDBiFungiDB:ATEG_09991.

Phylogenomic databases

HOGENOMiHOG000169951.
OMAiEVVFQRW.
OrthoDBiEOG092C2KMO.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMANC_ASPTN
AccessioniPrimary (citable) accession number: Q0C8J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.