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Q0C8J3

- MANC_ASPTN

UniProt

Q0C8J3 - MANC_ASPTN

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Protein

Probable mannan endo-1,4-beta-mannosidase C

Gene

manC

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

Catalytic activityi

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021Proton donorBy similarity
Active sitei320 – 3201NucleophileBy similarity

GO - Molecular functioni

  1. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannan endo-1,4-beta-mannosidase C (EC:3.2.1.78)
Alternative name(s):
Endo-beta-1,4-mannanase C
Gene namesi
Name:manC
ORF Names:ATEG_09991
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 406386Probable mannan endo-1,4-beta-mannosidase CPRO_0000393709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi33178.CADATEAP00001977.

Structurei

3D structure databases

ProteinModelPortaliQ0C8J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3934.
HOGENOMiHOG000169951.
OMAiMYWQYGY.
OrthoDBiEOG7C2R9T.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0C8J3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLINFEKVLS LALLAGSVSG RKHVPRGFVT TSGMKFQLDG KDFYFAGSNA
60 70 80 90 100
YYFPFNDNQT DVELGLAAAK QAGLTVFRTW GFNDKNATYI EGGLPAYGGE
110 120 130 140 150
GAGTTEVVFQ RWANGTSTID LEPFDKVVNA AKNTGMKLVV ALTNNWADYG
160 170 180 190 200
GMDVYTINLG GQYHDDFYRL PAIKKAYKRY VKEMVTRYRD SPAIMAWELA
210 220 230 240 250
NEPRCGADGV RNLPRSADGC NPEVLTAWID EMSTYIKKLD PHHLVTWGGE
260 270 280 290 300
GGFNIESDDW AYNGADGGDF DNELALPNID FGVFHSYPDW WSKTVSWTNQ
310 320 330 340 350
WIRDHAAAMR TGRKPVVHEE YGWLTPEARL EYLGTVSNIT RLEAVGGWQQ
360 370 380 390 400
ISVSEKMSDM YWQYGYSGYS YGRNHNDGFT IYLDDPEAKE LVYKHAKEVK

KLNRRH
Length:406
Mass (Da):45,768
Last modified:October 17, 2006 - v1
Checksum:i2D17F17F4806AC93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476609 Genomic DNA. Translation: EAU29440.1.
RefSeqiXP_001209293.1. XM_001209293.1.

Genome annotation databases

EnsemblFungiiCADATEAT00001977; CADATEAP00001977; CADATEAG00001977.
GeneIDi4319511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476609 Genomic DNA. Translation: EAU29440.1 .
RefSeqi XP_001209293.1. XM_001209293.1.

3D structure databases

ProteinModelPortali Q0C8J3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33178.CADATEAP00001977.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00001977 ; CADATEAP00001977 ; CADATEAG00001977 .
GeneIDi 4319511.

Phylogenomic databases

eggNOGi COG3934.
HOGENOMi HOG000169951.
OMAi MYWQYGY.
OrthoDBi EOG7C2R9T.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiMANC_ASPTN
AccessioniPrimary (citable) accession number: Q0C8J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3