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Q0C8J3

- MANC_ASPTN

UniProt

Q0C8J3 - MANC_ASPTN

Protein

Probable mannan endo-1,4-beta-mannosidase C

Gene

manC

Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei202 – 2021Proton donorBy similarity
    Active sitei320 – 3201NucleophileBy similarity

    GO - Molecular functioni

    1. mannan endo-1,4-beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannan endo-1,4-beta-mannosidase C (EC:3.2.1.78)
    Alternative name(s):
    Endo-beta-1,4-mannanase C
    Gene namesi
    Name:manC
    ORF Names:ATEG_09991
    OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
    Taxonomic identifieri341663 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000007963: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 406386Probable mannan endo-1,4-beta-mannosidase CPRO_0000393709Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi33178.CADATEAP00001977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0C8J3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3934.
    HOGENOMiHOG000169951.
    OMAiMYWQYGY.
    OrthoDBiEOG7C2R9T.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q0C8J3-1 [UniParc]FASTAAdd to Basket

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    MLINFEKVLS LALLAGSVSG RKHVPRGFVT TSGMKFQLDG KDFYFAGSNA    50
    YYFPFNDNQT DVELGLAAAK QAGLTVFRTW GFNDKNATYI EGGLPAYGGE 100
    GAGTTEVVFQ RWANGTSTID LEPFDKVVNA AKNTGMKLVV ALTNNWADYG 150
    GMDVYTINLG GQYHDDFYRL PAIKKAYKRY VKEMVTRYRD SPAIMAWELA 200
    NEPRCGADGV RNLPRSADGC NPEVLTAWID EMSTYIKKLD PHHLVTWGGE 250
    GGFNIESDDW AYNGADGGDF DNELALPNID FGVFHSYPDW WSKTVSWTNQ 300
    WIRDHAAAMR TGRKPVVHEE YGWLTPEARL EYLGTVSNIT RLEAVGGWQQ 350
    ISVSEKMSDM YWQYGYSGYS YGRNHNDGFT IYLDDPEAKE LVYKHAKEVK 400
    KLNRRH 406
    Length:406
    Mass (Da):45,768
    Last modified:October 17, 2006 - v1
    Checksum:i2D17F17F4806AC93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476609 Genomic DNA. Translation: EAU29440.1.
    RefSeqiXP_001209293.1. XM_001209293.1.

    Genome annotation databases

    EnsemblFungiiCADATEAT00001977; CADATEAP00001977; CADATEAG00001977.
    GeneIDi4319511.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH476609 Genomic DNA. Translation: EAU29440.1 .
    RefSeqi XP_001209293.1. XM_001209293.1.

    3D structure databases

    ProteinModelPortali Q0C8J3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 33178.CADATEAP00001977.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADATEAT00001977 ; CADATEAP00001977 ; CADATEAG00001977 .
    GeneIDi 4319511.

    Phylogenomic databases

    eggNOGi COG3934.
    HOGENOMi HOG000169951.
    OMAi MYWQYGY.
    OrthoDBi EOG7C2R9T.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NIH 2624 / FGSC A1156.

    Entry informationi

    Entry nameiMANC_ASPTN
    AccessioniPrimary (citable) accession number: Q0C8J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3