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Q0C8J3 (MANC_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannan endo-1,4-beta-mannosidase C

EC=3.2.1.78
Alternative name(s):
Endo-beta-1,4-mannanase C
Gene names
Name:manC
ORF Names:ATEG_09991
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans By similarity.

Catalytic activity

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannan endo-1,4-beta-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 406386Probable mannan endo-1,4-beta-mannosidase C
PRO_0000393709

Sites

Active site2021Proton donor By similarity
Active site3201Nucleophile By similarity

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation3381N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0C8J3 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 2D17F17F4806AC93

FASTA40645,768
        10         20         30         40         50         60 
MLINFEKVLS LALLAGSVSG RKHVPRGFVT TSGMKFQLDG KDFYFAGSNA YYFPFNDNQT 

        70         80         90        100        110        120 
DVELGLAAAK QAGLTVFRTW GFNDKNATYI EGGLPAYGGE GAGTTEVVFQ RWANGTSTID 

       130        140        150        160        170        180 
LEPFDKVVNA AKNTGMKLVV ALTNNWADYG GMDVYTINLG GQYHDDFYRL PAIKKAYKRY 

       190        200        210        220        230        240 
VKEMVTRYRD SPAIMAWELA NEPRCGADGV RNLPRSADGC NPEVLTAWID EMSTYIKKLD 

       250        260        270        280        290        300 
PHHLVTWGGE GGFNIESDDW AYNGADGGDF DNELALPNID FGVFHSYPDW WSKTVSWTNQ 

       310        320        330        340        350        360 
WIRDHAAAMR TGRKPVVHEE YGWLTPEARL EYLGTVSNIT RLEAVGGWQQ ISVSEKMSDM 

       370        380        390        400 
YWQYGYSGYS YGRNHNDGFT IYLDDPEAKE LVYKHAKEVK KLNRRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476609 Genomic DNA. Translation: EAU29440.1.
RefSeqXP_001209293.1. XM_001209293.1.

3D structure databases

ProteinModelPortalQ0C8J3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33178.CADATEAP00001977.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00001977; CADATEAP00001977; CADATEAG00001977.
GeneID4319511.

Phylogenomic databases

eggNOGCOG3934.
HOGENOMHOG000169951.
OMAMYWQYGY.
OrthoDBEOG7C2R9T.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANC_ASPTN
AccessionPrimary (citable) accession number: Q0C8J3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: October 17, 2006
Last modified: March 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries