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Q0C7P6

- EGLC_ASPTN

UniProt

Q0C7P6 - EGLC_ASPTN

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Protein

Probable glucan endo-1,3-beta-glucosidase eglC

Gene
eglC, ATEG_10288
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase By similarity.

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Nucleophile By similarity
Active sitei239 – 2391Proton donor By similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan endo-1,3-beta-glucosidase eglC (EC:3.2.1.39)
Alternative name(s):
Endo-1,3-beta-glucanase eglC
Laminarinase eglC
Gene namesi
Name:eglC
ORF Names:ATEG_10288
OrganismiAspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic identifieri341663 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000007963: Unassembled WGS sequence

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor By similarity. Secretedcell wall By similarity
Note: Covalently-linked GPI-modified cell wall protein By similarity.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell wall Source: UniProtKB-SubCell
  3. extracellular region Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 463445Probable glucan endo-1,3-beta-glucosidase eglCPRO_0000395147Add
BLAST
Propeptidei464 – 48623Removed in mature form Reviewed predictionPRO_0000395148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi396 – 3961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi404 – 4041N-linked (GlcNAc...) Reviewed prediction
Lipidationi463 – 4631GPI-anchor amidated glycine Reviewed prediction

Post-translational modificationi

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer By similarity.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliQ0C7P6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi310 – 457148Ser-richAdd
BLAST
Compositional biasi333 – 40270Gly-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5309.
OMAiTNTWWYI.
OrthoDBiEOG7TBCCK.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00332. Glyco_hydro_17. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0C7P6-1 [UniParc]FASTAAdd to Basket

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MQLTQLLALA LSLATSEAAY KGFNYGDKKP DGSSKYQADF ASEFETAQNL    50
VGAPGFTSAR LYTMIQAGTA NDPISAIPAA IAQNTSLLLG LWASGNNMNN 100
ELTALKAAIS QYGEDLSKLV VGISVGSEDL YRNSVLGQKV NAGVGVDPHV 150
LASYIEEVRS TISGTPLSGA PLGHVDTWND WVNGSNAAVI DAVDWVGFDG 200
YPYFQNTMAN SIDDAKALFN EAVAKTKSAA GNKEVWITET GWPVSGKTEN 250
LAVASIPNAK RFWDEVGCPL FDNTNTWWYT LQDAFGASVP NPSFGIVGST 300
LTTQPLFDLS CSKSNTTSSS AIASPTSTAA AAGGVAGGST GSASGSSTGT 350
GSSSGSGSNS NTGAASGAVG AADRETSGTS GSANTNGTSG SGSGSNSTSG 400
HGSNVTVPTR PTSVSNVSPS KSSSALFTGA ATSMGASPSS VGNVGPSKSS 450
GAASPSSTTM FTGAATSVSA PVVHVVLLAL MMVIAA 486
Length:486
Mass (Da):48,753
Last modified:October 17, 2006 - v1
Checksum:iF168A8CD88AF0DD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476610 Genomic DNA. Translation: EAU29285.1.
RefSeqiXP_001218636.1. XM_001218635.1.

Genome annotation databases

EnsemblFungiiCADATEAT00003164; CADATEAP00003164; CADATEAG00003164.
GeneIDi4354731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH476610 Genomic DNA. Translation: EAU29285.1 .
RefSeqi XP_001218636.1. XM_001218635.1.

3D structure databases

ProteinModelPortali Q0C7P6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADATEAT00003164 ; CADATEAP00003164 ; CADATEAG00003164 .
GeneIDi 4354731.

Phylogenomic databases

eggNOGi COG5309.
OMAi TNTWWYI.
OrthoDBi EOG7TBCCK.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00332. Glyco_hydro_17. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NIH 2624 / FGSC A1156.

Entry informationi

Entry nameiEGLC_ASPTN
AccessioniPrimary (citable) accession number: Q0C7P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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