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Q0C7P6 (EGLC_ASPTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucan endo-1,3-beta-glucosidase eglC

EC=3.2.1.39
Alternative name(s):
Endo-1,3-beta-glucanase eglC
Laminarinase eglC
Gene names
Name:eglC
ORF Names:ATEG_10288
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156) [Complete proteome]
Taxonomic identifier341663 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase By similarity.

Catalytic activity

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity. Secretedcell wall By similarity. Note: Covalently-linked GPI-modified cell wall protein By similarity.

Post-translational modification

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 17 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 463445Probable glucan endo-1,3-beta-glucosidase eglC
PRO_0000395147
Propeptide464 – 48623Removed in mature form Potential
PRO_0000395148

Regions

Compositional bias310 – 457148Ser-rich
Compositional bias333 – 40270Gly-rich

Sites

Active site1281Nucleophile By similarity
Active site2391Proton donor By similarity

Amino acid modifications

Lipidation4631GPI-anchor amidated glycine Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation3151N-linked (GlcNAc...) Potential
Glycosylation3861N-linked (GlcNAc...) Potential
Glycosylation3961N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q0C7P6 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: F168A8CD88AF0DD4

FASTA48648,753
        10         20         30         40         50         60 
MQLTQLLALA LSLATSEAAY KGFNYGDKKP DGSSKYQADF ASEFETAQNL VGAPGFTSAR 

        70         80         90        100        110        120 
LYTMIQAGTA NDPISAIPAA IAQNTSLLLG LWASGNNMNN ELTALKAAIS QYGEDLSKLV 

       130        140        150        160        170        180 
VGISVGSEDL YRNSVLGQKV NAGVGVDPHV LASYIEEVRS TISGTPLSGA PLGHVDTWND 

       190        200        210        220        230        240 
WVNGSNAAVI DAVDWVGFDG YPYFQNTMAN SIDDAKALFN EAVAKTKSAA GNKEVWITET 

       250        260        270        280        290        300 
GWPVSGKTEN LAVASIPNAK RFWDEVGCPL FDNTNTWWYT LQDAFGASVP NPSFGIVGST 

       310        320        330        340        350        360 
LTTQPLFDLS CSKSNTTSSS AIASPTSTAA AAGGVAGGST GSASGSSTGT GSSSGSGSNS 

       370        380        390        400        410        420 
NTGAASGAVG AADRETSGTS GSANTNGTSG SGSGSNSTSG HGSNVTVPTR PTSVSNVSPS 

       430        440        450        460        470        480 
KSSSALFTGA ATSMGASPSS VGNVGPSKSS GAASPSSTTM FTGAATSVSA PVVHVVLLAL 


MMVIAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH476610 Genomic DNA. Translation: EAU29285.1.
RefSeqXP_001218636.1. XM_001218635.1.

3D structure databases

ProteinModelPortalQ0C7P6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADATEAT00003164; CADATEAP00003164; CADATEAG00003164.
GeneID4354731.

Phylogenomic databases

eggNOGCOG5309.
OMATNTWWYI.
OrthoDBEOG7TBCCK.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00332. Glyco_hydro_17. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEGLC_ASPTN
AccessionPrimary (citable) accession number: Q0C7P6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries