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Q0C664 (Q0C664_HYPNA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA (guanine-N(1)-)-methyltransferase HAMAP MF_00605
EC=2.1.1.228 HAMAP MF_00605
Alternative name(s):
M1G-methyltransferase HAMAP MF_00605
tRNA [GM37] methyltransferase HAMAP MF_00605
Gene names
Name:trmD HAMAP MF_00605
Ordered Locus Names:HNE_0045
OrganismHyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP] EMBL ABI76092.1
Taxonomic identifier228405 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Hyphomonas

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity. HAMAP MF_00605

Catalytic activity

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. HAMAP MF_00605

Subunit structure

Homodimer By similarity. HAMAP MF_00605

Subcellular location

Cytoplasm By similarity HAMAP MF_00605.

Sequence similarities

Belongs to the RNA methyltransferase TrmD family. HAMAP MF_00605

Ontologies

Keywords
   Biological processtRNA processing HAMAP MF_00605
   Cellular componentCytoplasm HAMAP MF_00605
   LigandS-adenosyl-L-methionine HAMAP MF_00605
   Molecular functionMethyltransferase HAMAP MF_00605 EMBL ABI76092.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA (guanine-N1-)-methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region141 – 1466S-adenosyl-L-methionine binding By similarity HAMAP MF_00605

Sites

Binding site1211S-adenosyl-L-methionine; via amide nitrogen By similarity HAMAP MF_00605

Sequences

Sequence LengthMass (Da)Tools
Q0C664 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: B4013284F51AC4D7

FASTA25127,242
        10         20         30         40         50         60 
MFKATAITLI PEAWPGPLGA SILGRARAEG IWDLETVDLR TFGLGKHRKV DDTPAGGGAG 

        70         80         90        100        110        120 
LVLRPDVAAA AVDSVQKCPD LSRSVPAMTR PVVYLSPRGR RFDQEMARQW AAGPGVILFC 

       130        140        150        160        170        180 
GRFEGLDERA IEARDMQEVS LGDFVLAGGD VAAMAMLEAA IRLLPGVAGN SASITGESFE 

       190        200        210        220        230        240 
NGLLEYPHYT LPREWEGRQT PPVLLSGDHR RIEEWRISRS KALTFDRRPD LYAAYSETPT 

       250 
PTAPETGDEP D

« Hide

References

[1]"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus."
Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. expand/collapse author list , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L.
J. Bacteriol. 188:6841-6850(2006) [PubMed: 16980487] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000158 Genomic DNA. Translation: ABI76092.1.
RefSeqYP_758779.1. NC_008358.1.

3D structure databases

ProteinModelPortalQ0C664.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0C664.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4288057.
GenomeReviewsGene locus HNE_0045 in contig CP000158_GR.
KEGGhne:HNE_0045.
NMPDRfig|228405.5.peg.45.
PATRIC32212874. VBIHypNep17450_0045.
TIGRHNE_0045.

Phylogenomic databases

eggNOGCOG0336.
HOGENOMHBG285805.
OMAVCGRFEG.

Family and domain databases

HAMAPMF_00605. TrmD.
[Tree]
InterProIPR016009. tRNA_m1G_MeTrfase.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
[Graphical view]
Gene3DG3DSA:1.10.1270.20. tRNA_m1G_MeTrfase_C. 1 hit.
KOK00554.
PANTHERPTHR10056. PTHR10056. 1 hit.
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFPIRSF000386. tRNA_mtase. 1 hit.
TIGRFAMsTIGR00088. TrmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ0C664_HYPNA
AccessionPrimary (citable) accession number: Q0C664
Entry history
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info