Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q0C618 (UPPP_HYPNA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:HNE_0091
OrganismHyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP]
Taxonomic identifier228405 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290715

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane233 – 25321Helical; Potential
Transmembrane259 – 27921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0C618 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 01C6D9B68CB2DF45

FASTA28529,505
        10         20         30         40         50         60 
MSILQLVLIA LMQGITEWLP ISSSAHVMLV SDVVGLAGRD ELLINAASNA GTLLAMLLYF 

        70         80         90        100        110        120 
RKDVAAAIAG GFELLGAPVT RKPLSAGGRL ALCILVATPF ALAGAVIYEN FIPENIWTAL 

       130        140        150        160        170        180 
RSVYAVAAST IVFGALLWWA DARGGQSRSE GDMTLRDAFL IGASQLVAVI IPGTSRSGIT 

       190        200        210        220        230        240 
MTAARALGYE RVEAARFSML IGAPILAAVS LYGLLGLATT PADGMGASLT DGLIVAALAF 

       250        260        270        280 
VSGYASIGLL MALLRKMSFL PFVLYRFALG IALLATSPIV AGAMG 

« Hide

References

[1]"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus."
Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. expand/collapse author list , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L.
J. Bacteriol. 188:6841-6850(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15444.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000158 Genomic DNA. Translation: ABI77648.1.
RefSeqYP_758825.1. NC_008358.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228405.HNE_0091.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI77648; ABI77648; HNE_0091.
GeneID4288119.
KEGGhne:HNE_0091.
PATRIC32212966. VBIHypNep17450_0091.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWEFLATG.
OrthoDBEOG6QP13M.
ProtClustDBCLSK777537.

Enzyme and pathway databases

BioCycHNEP228405:GI69-91-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_HYPNA
AccessionPrimary (citable) accession number: Q0C618
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families