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Q0C618

- UPPP_HYPNA

UniProt

Q0C618 - UPPP_HYPNA

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: JCVI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciHNEP228405:GI69-91-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:HNE_0091
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Undecaprenyl-diphosphatasePRO_0000290715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_0091.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalUniRule annotationAdd
BLAST
Transmembranei92 – 11221HelicalUniRule annotationAdd
BLAST
Transmembranei122 – 14221HelicalUniRule annotationAdd
BLAST
Transmembranei159 – 17921HelicalUniRule annotationAdd
BLAST
Transmembranei197 – 21721HelicalUniRule annotationAdd
BLAST
Transmembranei233 – 25321HelicalUniRule annotationAdd
BLAST
Transmembranei259 – 27921HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiWDKIMST.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0C618 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILQLVLIA LMQGITEWLP ISSSAHVMLV SDVVGLAGRD ELLINAASNA
60 70 80 90 100
GTLLAMLLYF RKDVAAAIAG GFELLGAPVT RKPLSAGGRL ALCILVATPF
110 120 130 140 150
ALAGAVIYEN FIPENIWTAL RSVYAVAAST IVFGALLWWA DARGGQSRSE
160 170 180 190 200
GDMTLRDAFL IGASQLVAVI IPGTSRSGIT MTAARALGYE RVEAARFSML
210 220 230 240 250
IGAPILAAVS LYGLLGLATT PADGMGASLT DGLIVAALAF VSGYASIGLL
260 270 280
MALLRKMSFL PFVLYRFALG IALLATSPIV AGAMG
Length:285
Mass (Da):29,505
Last modified:October 17, 2006 - v1
Checksum:i01C6D9B68CB2DF45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77648.1.
RefSeqiWP_011645125.1. NC_008358.1.
YP_758825.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI77648; ABI77648; HNE_0091.
GeneIDi4288119.
KEGGihne:HNE_0091.
PATRICi32212966. VBIHypNep17450_0091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77648.1 .
RefSeqi WP_011645125.1. NC_008358.1.
YP_758825.1. NC_008358.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_0091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI77648 ; ABI77648 ; HNE_0091 .
GeneIDi 4288119.
KEGGi hne:HNE_0091.
PATRICi 32212966. VBIHypNep17450_0091.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi WDKIMST.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci HNEP228405:GI69-91-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiUPPP_HYPNA
AccessioniPrimary (citable) accession number: Q0C618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3