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Q0C600

- TRMB_HYPNA

UniProt

Q0C600 - TRMB_HYPNA

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, HNE_0109
Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511S-adenosyl-L-methionine By similarity
Binding sitei76 – 761S-adenosyl-L-methionine By similarity
Binding sitei103 – 1031S-adenosyl-L-methionine By similarity
Active sitei125 – 1251 By similarity
Binding sitei125 – 1251S-adenosyl-L-methionine By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei161 – 1611Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciHNEP228405:GI69-109-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:HNE_0109
    OrganismiHyphomonas neptunium (strain ATCC 15444)
    Taxonomic identifieri228405 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
    ProteomesiUP000001959: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288159Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi228405.HNE_0109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0C600.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni199 – 2024Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiRAFYGRR.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0C600-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSFGRTGGR PLSPRQKTLM AEKLDTYRIA EGDGPLDLCA MFPGKEAFWL    50
    EIGFGGAEHM IAQAAQNPDV GIIGCEPFLE GIAKALGGIE ETDLNNVRVW 100
    PDDARPLIAR MPDQCLDRAF VLFPDPWPKR RQHKRRLVQA DFLSILHPKM 150
    KPGARLRFAT DVKSYADEAL LTFVSDGRFE WLAASPDDWR CPPQDHVTTR 200
    YESKRLGDCK PVWFDFRIR 219
    Length:219
    Mass (Da):24,900
    Last modified:October 17, 2006 - v1
    Checksum:i68CB3009E2F1DF9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI76398.1.
    RefSeqiYP_758843.1. NC_008358.1.

    Genome annotation databases

    EnsemblBacteriaiABI76398; ABI76398; HNE_0109.
    GeneIDi4288247.
    KEGGihne:HNE_0109.
    PATRICi32213002. VBIHypNep17450_0109.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI76398.1 .
    RefSeqi YP_758843.1. NC_008358.1.

    3D structure databases

    ProteinModelPortali Q0C600.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 228405.HNE_0109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI76398 ; ABI76398 ; HNE_0109 .
    GeneIDi 4288247.
    KEGGi hne:HNE_0109.
    PATRICi 32213002. VBIHypNep17450_0109.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi RAFYGRR.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci HNEP228405:GI69-109-MONOMER.

    Family and domain databases

    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15444.

    Entry informationi

    Entry nameiTRMB_HYPNA
    AccessioniPrimary (citable) accession number: Q0C600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 17, 2006
    Last modified: June 11, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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