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Q0C4V1

- DEF_HYPNA

UniProt

Q0C4V1 - DEF_HYPNA

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Protein

Peptide deformylase

Gene

def

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951IronUniRule annotation
Metal bindingi137 – 1371IronUniRule annotation
Active sitei138 – 1381UniRule annotation
Metal bindingi141 – 1411IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHNEP228405:GI69-512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:HNE_0512
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Peptide deformylasePRO_0000301040Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_0512.

Structurei

3D structure databases

ProteinModelPortaliQ0C4V1.
SMRiQ0C4V1. Positions 2-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiVEYLSPF.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0C4V1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIREILTVP DPRLKQVSKP VEGGVTDDIR ALMDDMLETM YDAPGIGLAA
60 70 80 90 100
IQIGVPLRVI VMDLAREGEE PAPRYFVNPE ILETIEEKKP YEEGCLSVPD
110 120 130 140 150
IFDQVERSAR CRIRYLDYDG KQVDEWAEDL YAVCIQHEMD HLEGTLFIDY
160 170
LSRLKRDRAI DKVKKAKIRA IREDAN
Length:176
Mass (Da):20,178
Last modified:October 17, 2006 - v1
Checksum:iB7EC65796CA43467
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI78719.1.
RefSeqiWP_011645542.1. NC_008358.1.
YP_759242.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI78719; ABI78719; HNE_0512.
GeneIDi4290364.
KEGGihne:HNE_0512.
PATRICi32213816. VBIHypNep17450_0513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI78719.1 .
RefSeqi WP_011645542.1. NC_008358.1.
YP_759242.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0C4V1.
SMRi Q0C4V1. Positions 2-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_0512.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI78719 ; ABI78719 ; HNE_0512 .
GeneIDi 4290364.
KEGGi hne:HNE_0512.
PATRICi 32213816. VBIHypNep17450_0513.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi VEYLSPF.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci HNEP228405:GI69-512-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiDEF_HYPNA
AccessioniPrimary (citable) accession number: Q0C4V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3