Q0C4M2 (OTC_HYPNA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	HNE_0592

Organism

Hyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP]

Taxonomic identifier

228405 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Hyphomonas

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000065095
Regions
	Region	58 – 62	5	Carbamoyl phosphate binding By similarity
	Region	265 – 268	4	Ornithine binding By similarity
Sites
	Binding site	109	1	Carbamoyl phosphate By similarity
	Binding site	136	1	Carbamoyl phosphate By similarity
	Site	28	1	Important for structural integrity By similarity
	Site	149	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0C4M2 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 27D658FB0ED84885	FASTA	308	33,442
	10 20 30 40 50 60 MTIRHFLDIW PLESAELRAI LDQAHAMKKA RAGWPKGKID AGAPLDGHTL AMIFEKSSTR 70 80 90 100 110 120 TRFSFDMAMR QLGGSSITAT SNDMQLGRGE TVEDTAKVLS RFVDAVMIRA NDHADVEAFA 130 140 150 160 170 180 DAASVPVING LTDRSHPCQI MADLMTLEEH GLTLRGARLA WVGDGNNVCA SFIHAAPKFG 190 200 210 220 230 240 FSLAVGTPKR FAPDEDDLEI AAELQGRIDL YETAEEAVAG ADVVIADTFV SMGDVDAERR 250 260 270 280 290 300 LEILDPYAVT EELMELAAGG AKFLHCLPAH RGEEVDAEVI DGPASLVFDE AENRLHAQKA ILRWCLGK

References

[1]

"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus." Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L. J. Bacteriol. 188:6841-6850(2006) [PubMed: 16980487] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15444.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000158 Genomic DNA. Translation: ABI78192.1.
RefSeq	YP_759321.1. NC_008358.1.
3D structure databases
ProteinModelPortal	Q0C4M2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0C4M2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4290222.
GenomeReviews	Gene locus HNE_0592 in contig CP000158_GR.
KEGG	hne:HNE_0592.
NMPDR	fig|228405.5.peg.580.
PATRIC	32213984. VBIHypNep17450_0596.
TIGR	HNE_0592.
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	GVDCVVT.
PhylomeDB	Q0C4M2.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	HNEP81032:HNE_0592-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_HYPNA

Accession

Primary (citable) accession number: Q0C4M2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program