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Protein

Alanine racemase

Gene

alr1

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr2), Alanine racemase (alr1)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Active sitei247Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei295Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHNEP228405:G1G5G-723-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr1Imported
Ordered Locus Names:HNE_0725Imported
OrganismiHyphomonas neptunium (strain ATCC 15444)Imported
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
Proteomesi
  • UP000001959 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_0725

Structurei

3D structure databases

ProteinModelPortaliQ0C490
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 351Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiCALHVDT
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q0C490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQMPRATVL TGNIADNWRT LDALHPGATT AAVVKADAYG LGAMRVARAL
60 70 80 90 100
RIAGCQTFFV AYAEEGLIVR KAAGKAARIF VLNGPVRSEM ATYRDADLTA
110 120 130 140 150
VLSSEAHVKL WGTAPKGSCA LHFDTGMNRL GLPMDMSEKD LAALRRLQPV
160 170 180 190 200
LIMSHLACAD DPENPANTAQ RKAFNEISDA FPDTPASLAN SNGCYLGKGF
210 220 230 240 250
AYDLTRPGLA LYGGTTPPEK VKLKPGVILE ASILATFSGQ TGTKVGYGGT
260 270 280 290 300
HTLPEDRILA TCALGYADGI PRAGANQITG WLEGNPCPVL GRISMDLITL
310 320 330 340 350
DVTDCVKHAK PGARVEFLGE NAKLEVQAAA CGTLGYELLT GLGPRVQRVY

R
Length:351
Mass (Da):37,173
Last modified:October 17, 2006 - v1
Checksum:iB971162725F6DEF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA Translation: ABI76247.1
RefSeqiWP_011645753.1, NC_008358.1

Genome annotation databases

EnsemblBacteriaiABI76247; ABI76247; HNE_0725
KEGGihne:HNE_0725

Similar proteinsi

Entry informationi

Entry nameiQ0C490_HYPNA
AccessioniPrimary (citable) accession number: Q0C490
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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