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Q0C490 (Q0C490_HYPNA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP-Rule MF_01201

EC=5.1.1.1 HAMAP-Rule MF_01201
Gene names
Name:alr1 EMBL ABI76247.1
Ordered Locus Names:HNE_0725 EMBL ABI76247.1
OrganismHyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP] EMBL ABI76247.1
Taxonomic identifier228405 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS009006

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS009006

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site351Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2471Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1291Substrate By similarity HAMAP-Rule MF_01201
Binding site2951Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue351N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
Q0C490 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: B971162725F6DEF1

FASTA35137,173
        10         20         30         40         50         60 
MSQMPRATVL TGNIADNWRT LDALHPGATT AAVVKADAYG LGAMRVARAL RIAGCQTFFV 

        70         80         90        100        110        120 
AYAEEGLIVR KAAGKAARIF VLNGPVRSEM ATYRDADLTA VLSSEAHVKL WGTAPKGSCA 

       130        140        150        160        170        180 
LHFDTGMNRL GLPMDMSEKD LAALRRLQPV LIMSHLACAD DPENPANTAQ RKAFNEISDA 

       190        200        210        220        230        240 
FPDTPASLAN SNGCYLGKGF AYDLTRPGLA LYGGTTPPEK VKLKPGVILE ASILATFSGQ 

       250        260        270        280        290        300 
TGTKVGYGGT HTLPEDRILA TCALGYADGI PRAGANQITG WLEGNPCPVL GRISMDLITL 

       310        320        330        340        350 
DVTDCVKHAK PGARVEFLGE NAKLEVQAAA CGTLGYELLT GLGPRVQRVY R 

« Hide

References

[1]"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus."
Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. expand/collapse author list , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L.
J. Bacteriol. 188:6841-6850(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15444 EMBL ABI76247.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000158 Genomic DNA. Translation: ABI76247.1.
RefSeqYP_759453.1. NC_008358.1.

3D structure databases

ProteinModelPortalQ0C490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228405.HNE_0725.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI76247; ABI76247; HNE_0725.
GeneID4289560.
KEGGhne:HNE_0725.
PATRIC32214258. VBIHypNep17450_0732.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031445.
KOK01775.
OMAQYELLTG.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycHNEP228405:GI69-725-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ0C490_HYPNA
AccessionPrimary (citable) accession number: Q0C490
Entry history
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)