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Q0C490

- Q0C490_HYPNA

UniProt

Q0C490 - Q0C490_HYPNA

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Protein

Alanine racemase

Gene

alr1

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Active sitei247 – 2471Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei295 – 2951Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHNEP228405:GI69-725-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr1Imported
Ordered Locus Names:HNE_0725Imported
OrganismiHyphomonas neptunium (strain ATCC 15444)Imported
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_0725.

Structurei

3D structure databases

ProteinModelPortaliQ0C490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiIAINAVE.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0C490-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQMPRATVL TGNIADNWRT LDALHPGATT AAVVKADAYG LGAMRVARAL
60 70 80 90 100
RIAGCQTFFV AYAEEGLIVR KAAGKAARIF VLNGPVRSEM ATYRDADLTA
110 120 130 140 150
VLSSEAHVKL WGTAPKGSCA LHFDTGMNRL GLPMDMSEKD LAALRRLQPV
160 170 180 190 200
LIMSHLACAD DPENPANTAQ RKAFNEISDA FPDTPASLAN SNGCYLGKGF
210 220 230 240 250
AYDLTRPGLA LYGGTTPPEK VKLKPGVILE ASILATFSGQ TGTKVGYGGT
260 270 280 290 300
HTLPEDRILA TCALGYADGI PRAGANQITG WLEGNPCPVL GRISMDLITL
310 320 330 340 350
DVTDCVKHAK PGARVEFLGE NAKLEVQAAA CGTLGYELLT GLGPRVQRVY

R
Length:351
Mass (Da):37,173
Last modified:October 17, 2006 - v1
Checksum:iB971162725F6DEF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI76247.1.
RefSeqiWP_011645753.1. NC_008358.1.
YP_759453.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI76247; ABI76247; HNE_0725.
GeneIDi4289560.
KEGGihne:HNE_0725.
PATRICi32214258. VBIHypNep17450_0732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI76247.1 .
RefSeqi WP_011645753.1. NC_008358.1.
YP_759453.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0C490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_0725.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI76247 ; ABI76247 ; HNE_0725 .
GeneIDi 4289560.
KEGGi hne:HNE_0725.
PATRICi 32214258. VBIHypNep17450_0732.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031445.
KOi K01775.
OMAi IAINAVE.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci HNEP228405:GI69-725-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444Imported.

Entry informationi

Entry nameiQ0C490_HYPNA
AccessioniPrimary (citable) accession number: Q0C490
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3