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Q0C2Z8

- Q0C2Z8_HYPNA

UniProt

Q0C2Z8 - Q0C2Z8_HYPNA

Protein

Isocitrate dehydrogenase [NADP]

Gene

HNE_1177

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADP
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi308 – 3136NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciHNEP228405:GI69-1177-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:HNE_1177Imported
    OrganismiHyphomonas neptunium (strain ATCC 15444)Imported
    Taxonomic identifieri228405 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
    ProteomesiUP000001959: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi228405.HNE_1177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0C2Z8.
    SMRiQ0C2Z8. Positions 3-404.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0C2Z8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVKNPI VEMDGDEMTR IIWQLIKDKL IHPYLDIDLK YYDLSIEKRD    50
    ETDDQITIDS AEATKKYGVA VKCATITPDE ARVEEFGLKK MWKSPNGTIR 100
    NILGGVVFRE PIVISNIPRL VPGWTKPVII GRHAFGDQYR ATDFLVPGKG 150
    KLTMKFEGED GKVIEKEIFD FPSAGIAMGM YNLDDSIRDF ARASFNYGLQ 200
    RKLPVYLSTK NTILKAYDGR FKDIFQEEWD KEFKAKFAEF KGTYEHRLID 250
    DMVAAAMKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLSPDGKT 300
    VEAEAAHGTV TRHYRAHQKG EATSTNSIAS IYAWTQGLDH RGRMDETPEV 350
    RKFAQTLEKT IIKTVEAGFM TKDLALLVGP DQGYLTTEGF IEKVAQNLEI 400
    EMGKA 405
    Length:405
    Mass (Da):45,591
    Last modified:October 17, 2006 - v1
    Checksum:i8BD6376785EEC66B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77790.1.
    RefSeqiYP_759895.1. NC_008358.1.

    Genome annotation databases

    EnsemblBacteriaiABI77790; ABI77790; HNE_1177.
    GeneIDi4289182.
    KEGGihne:HNE_1177.
    PATRICi32215161. VBIHypNep17450_1176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77790.1 .
    RefSeqi YP_759895.1. NC_008358.1.

    3D structure databases

    ProteinModelPortali Q0C2Z8.
    SMRi Q0C2Z8. Positions 3-404.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228405.HNE_1177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI77790 ; ABI77790 ; HNE_1177 .
    GeneIDi 4289182.
    KEGGi hne:HNE_1177.
    PATRICi 32215161. VBIHypNep17450_1176.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci HNEP228405:GI69-1177-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15444Imported.

    Entry informationi

    Entry nameiQ0C2Z8_HYPNA
    AccessioniPrimary (citable) accession number: Q0C2Z8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 17, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3