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Q0C2Z8 (Q0C2Z8_HYPNA) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:HNE_1177 EMBL ABI77790.1
OrganismHyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP] EMBL ABI77790.1
Taxonomic identifier228405 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity
Nucleotide binding308 – 3136NADP By similarity
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q0C2Z8 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 8BD6376785EEC66B

FASTA40545,591
        10         20         30         40         50         60 
MAKIKVKNPI VEMDGDEMTR IIWQLIKDKL IHPYLDIDLK YYDLSIEKRD ETDDQITIDS 

        70         80         90        100        110        120 
AEATKKYGVA VKCATITPDE ARVEEFGLKK MWKSPNGTIR NILGGVVFRE PIVISNIPRL 

       130        140        150        160        170        180 
VPGWTKPVII GRHAFGDQYR ATDFLVPGKG KLTMKFEGED GKVIEKEIFD FPSAGIAMGM 

       190        200        210        220        230        240 
YNLDDSIRDF ARASFNYGLQ RKLPVYLSTK NTILKAYDGR FKDIFQEEWD KEFKAKFAEF 

       250        260        270        280        290        300 
KGTYEHRLID DMVAAAMKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLSPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRAHQKG EATSTNSIAS IYAWTQGLDH RGRMDETPEV RKFAQTLEKT 

       370        380        390        400 
IIKTVEAGFM TKDLALLVGP DQGYLTTEGF IEKVAQNLEI EMGKA 

« Hide

References

[1]"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus."
Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. expand/collapse author list , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L.
J. Bacteriol. 188:6841-6850(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15444 EMBL ABI77790.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000158 Genomic DNA. Translation: ABI77790.1.
RefSeqYP_759895.1. NC_008358.1.

3D structure databases

ProteinModelPortalQ0C2Z8.
SMRQ0C2Z8. Positions 3-404.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228405.HNE_1177.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI77790; ABI77790; HNE_1177.
GeneID4289182.
KEGGhne:HNE_1177.
PATRIC32215161. VBIHypNep17450_1176.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycHNEP228405:GI69-1177-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ0C2Z8_HYPNA
AccessionPrimary (citable) accession number: Q0C2Z8
Entry history
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 13, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)