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Q0C2Z8

- Q0C2Z8_HYPNA

UniProt

Q0C2Z8 - Q0C2Z8_HYPNA

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Protein

Isocitrate dehydrogenase [NADP]

Gene

HNE_1177

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADP
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADP
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP
Nucleotide bindingi308 – 3136NADP

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciHNEP228405:GI69-1177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:HNE_1177Imported
OrganismiHyphomonas neptunium (strain ATCC 15444)Imported
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_1177.

Structurei

3D structure databases

ProteinModelPortaliQ0C2Z8.
SMRiQ0C2Z8. Positions 3-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0C2Z8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVKNPI VEMDGDEMTR IIWQLIKDKL IHPYLDIDLK YYDLSIEKRD
60 70 80 90 100
ETDDQITIDS AEATKKYGVA VKCATITPDE ARVEEFGLKK MWKSPNGTIR
110 120 130 140 150
NILGGVVFRE PIVISNIPRL VPGWTKPVII GRHAFGDQYR ATDFLVPGKG
160 170 180 190 200
KLTMKFEGED GKVIEKEIFD FPSAGIAMGM YNLDDSIRDF ARASFNYGLQ
210 220 230 240 250
RKLPVYLSTK NTILKAYDGR FKDIFQEEWD KEFKAKFAEF KGTYEHRLID
260 270 280 290 300
DMVAAAMKWS GGYVWACKNY DGDVQSDTVA QGYGSLGLMT SVLLSPDGKT
310 320 330 340 350
VEAEAAHGTV TRHYRAHQKG EATSTNSIAS IYAWTQGLDH RGRMDETPEV
360 370 380 390 400
RKFAQTLEKT IIKTVEAGFM TKDLALLVGP DQGYLTTEGF IEKVAQNLEI

EMGKA
Length:405
Mass (Da):45,591
Last modified:October 17, 2006 - v1
Checksum:i8BD6376785EEC66B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77790.1.
RefSeqiWP_011646195.1. NC_008358.1.
YP_759895.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI77790; ABI77790; HNE_1177.
GeneIDi4289182.
KEGGihne:HNE_1177.
PATRICi32215161. VBIHypNep17450_1176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77790.1 .
RefSeqi WP_011646195.1. NC_008358.1.
YP_759895.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0C2Z8.
SMRi Q0C2Z8. Positions 3-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_1177.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI77790 ; ABI77790 ; HNE_1177 .
GeneIDi 4289182.
KEGGi hne:HNE_1177.
PATRICi 32215161. VBIHypNep17450_1176.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci HNEP228405:GI69-1177-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444Imported.

Entry informationi

Entry nameiQ0C2Z8_HYPNA
AccessioniPrimary (citable) accession number: Q0C2Z8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3