ID   Q0C1Q4_HYPNA            Unreviewed;       792 AA.
AC   Q0C1Q4;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=HNE_1631 {ECO:0000313|EMBL:ABI77136.1};
OS   Hyphomonas neptunium (strain ATCC 15444).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC   Hyphomonadaceae; Hyphomonas.
OX   NCBI_TaxID=228405 {ECO:0000313|EMBL:ABI77136.1, ECO:0000313|Proteomes:UP000001959};
RN   [1] {ECO:0000313|EMBL:ABI77136.1, ECO:0000313|Proteomes:UP000001959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15444 {ECO:0000313|EMBL:ABI77136.1,
RC   ECO:0000313|Proteomes:UP000001959};
RX   PubMed=16980487; DOI=10.1128/JB.00111-06;
RA   Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G.,
RA   Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D.,
RA   Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R.,
RA   Brinkac L.M., Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G.,
RA   Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N.,
RA   Ward N.L.;
RT   "Comparative genomic evidence for a close relationship between the
RT   dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter
RT   crescentus.";
RL   J. Bacteriol. 188:6841-6850(2006).
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DR   EMBL; CP000158; ABI77136.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0C1Q4; -.
DR   STRING; 228405.HNE_1631; -.
DR   KEGG; hne:HNE_1631; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_007799_0_0_5; -.
DR   Proteomes; UP000001959; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF6; SERINE_THREONINE-PROTEIN KINASE NEKL-3; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Kinase {ECO:0000313|EMBL:ABI77136.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001959};
KW   Transferase {ECO:0000313|EMBL:ABI77136.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        347..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          83..500
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         114
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   792 AA;  86577 MW;  EF06EDA3FE743340 CRC64;
     MKRGRMSTGS IDRFALELLS QALDMPSDQR EDWVRNKCAG DAALEKRVLG LLATERAHPG
     ALKTGGARHD AVEPEAPERV GAYRIIETIG QGGMGAVYKG ERASGNFDHT VAIKIIRPGV
     LSEALIERFE RERQILAALN HPNIARLYDG GEMEDGSPYM IMEYVDGEPV LSWAERTGAS
     IRERLDLFQS LCGAVQFAHQ NLIIHRDITP SNVLVNKDGL VKLIDFGISK SPDQTAPARF
     TAPGSKTAMS YTPGYAAPER SRGAVANTLS DVYSLGKLLS DLLKSGETRP ELMAIIKCAT
     ANEPEDRYAS VDALNEDVTN FRTGKPVSAF SDSGAYRFRK FVGRHKITVA SIAAVIIGLS
     ATLAATVVQY NRAEAALAVA NDRFTQAREL SRTLVFDIYD ETQKISGSLE ARKALAGVVR
     DYVSGLELDE TAPEDVLVEV GIITSRLADL YGGVGIANLG ENEQSMALFL DAQKTLNDAL
     ARNPADKTAI AELLMVERML TMQNYYHKND LTAAHAANDR ALALAERGLA LGPDGERPIL
     KHFWSIRTDE LQLLDAEKRT EEALGKVRQW RTELTPEMAE RLGGSAEMEA YFASQEAMLL
     IDDNRGEEAM EPLTTAITLR SQQLSEAPEN YYYKVQLMVA QGEMATALRL AGDIAASRDA
     AIEAVKLARE IMAENTEDAG GPEGLSAMLQ KLATAEFNSD NFPAAKVAIE EAATLLEKLV
     EQFPTDPFYQ VRLLNVLSQS VEFDTEDAGK SWSCGLIRNA GLYFDVQATL DNPEAGWEED
     QIRPLLDVSC ET
//