Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase

Gene

katG

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Transition state stabilizerUniRule annotation
Active sitei98 – 981Proton acceptorUniRule annotation
Metal bindingi266 – 2661Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciHNEP228405:GI69-2116-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:HNE_2115
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
Proteomesi
  • UP000001959 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929UniRule annotationAdd
BLAST
Chaini30 – 723694Catalase-peroxidasePRO_0000354809Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki97 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-97)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ0C0D1.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi228405.HNE_2115.

Structurei

3D structure databases

ProteinModelPortaliQ0C0D1.
SMRiQ0C0D1. Positions 24-722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0C0D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGNDLVENK CPVMHGGITV AGHSNTAWWP ETLNLEILHQ HDTKVSPLGK
60 70 80 90 100
DFNYRDAVKS LDFEALKKDM HDLMTNSQDW WPADYGHYGG LMIRLAWHSA
110 120 130 140 150
GSYRLADGRG GGNTGNIRFA PLNSWPDNGN LDKARRLLWP IKKKYGNKIS
160 170 180 190 200
WADLILLSGT IAYESMGLKT YGFSFGREDI WAPEKDVYWG AEKEWLAPSD
210 220 230 240 250
ERYTDVDKPE TMENPLAAVQ MGLIYVNPEG VNGKSDPLKS AAQVRETFAR
260 270 280 290 300
MAMNDEETAA LTCGGHTVGK AHGNGDAGKL SPPPEGNDLE TQGFGWMNPN
310 320 330 340 350
MDGKATNAVT SGIEGAWTTH PTKWDMGYFH LLFGYEWELT KSPAGASQWR
360 370 380 390 400
PINIKEEDMP VDPTDPTKRV MPMMTDADMA MKMDPAYNAI CQKFMADQAY
410 420 430 440 450
FSDTFARAWF KLTHRDLGPR VRYIGPDAPQ EDLIWQDPVP AGSKSYDVAA
460 470 480 490 500
VKAKIADSGL SLSEMVSTAW DSARTFRGSD LRGGANGARI RLAPQKDWAG
510 520 530 540 550
NEPARLQKVL SVLEPIASAT GASVADVIVL AGNVGVEQAA KAAGFDISVP
560 570 580 590 600
FSPGRGDATA EMTDADSFES LEPYADGFRN WQKEDYVVKP EELLLDRAQL
610 620 630 640 650
LGLTGPEMTV LLGGMRVMGT NHGGTKHGVF TDKVGALTND FFVNLTDMAN
660 670 680 690 700
KWVPRGKNAY DITDRKSGAV KFTATRADLV FGSNSILRAY AEIYAQDDAK
710 720
EKFVKDFVAA WSKVMDADRF DLA
Length:723
Mass (Da):79,522
Last modified:October 17, 2006 - v1
Checksum:iF852D8F2C535EDD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI78396.1.
RefSeqiWP_011647110.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI78396; ABI78396; HNE_2115.
KEGGihne:HNE_2115.
PATRICi32217073. VBIHypNep17450_2120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI78396.1.
RefSeqiWP_011647110.1. NC_008358.1.

3D structure databases

ProteinModelPortaliQ0C0D1.
SMRiQ0C0D1. Positions 24-722.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228405.HNE_2115.

Proteomic databases

PRIDEiQ0C0D1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI78396; ABI78396; HNE_2115.
KEGGihne:HNE_2115.
PATRICi32217073. VBIHypNep17450_2120.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciHNEP228405:GI69-2116-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_HYPNA
AccessioniPrimary (citable) accession number: Q0C0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.