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Q0BYP8 (SYR_HYPNA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:HNE_2715
OrganismHyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP]
Taxonomic identifier228405 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018043

Regions

Motif123 – 13311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q0BYP8 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: BB35B7B72683BE2B

FASTA58963,441
        10         20         30         40         50         60 
MTSLAKNLSA AAGAAFEAMG LEARFGEVRR SDKPELADFQ CNGAMAAAKA AGKNPREIAG 

        70         80         90        100        110        120 
EIAARLKEHA SVLSAEVAGP GFINLRVSDA ALSARAEHVR GDAMAGAEKA ADAAVTVIDF 

       130        140        150        160        170        180 
GGANVAKPMH VGHLRSAVIG DTLQRICRFA GDEVTSDVHL GDWGLQMGHL VTELYDEQPG 

       190        200        210        220        230        240 
LIYFDAAYTG PYPAEPPVTI DDLGRLYPQA SNKAKADAAR NERSQKAVAE MQAGRPGYRA 

       250        260        270        280        290        300 
LLRHFIEVSI EALKLDYGFL NVSFDLWKGE SDVDGLIPGL VERFKQAGLA EESDGALIVH 

       310        320        330        340        350        360 
VARETDKKEM PPVMLVNSRG GTGYHTTDLA TILDRMDTLT TTPERMLYVV DQRQALHFEQ 

       370        380        390        400        410        420 
VFRAAGMLGL IAEDKLEHIG FGTVNGADGK PFKTREGGVL RLADLQAMAM EEAEKKLSAA 

       430        440        450        460        470        480 
NLPADMGDAE RFDVAKKVAV AALRFSDLMN TRTTNYVFDL ERFTSFEGKT GPYLMYAAVR 

       490        500        510        520        530        540 
VKSVLRKAAE NGHSAGKVVV TEDAERTLVL QLDGFGAALL GAREKRMPHI LCEHLYGLAQ 

       550        560        570        580 
AFSSFYAALP IAAEADGEKR ASRLALADGV RHQLETGLEL LGIAVPERM 

« Hide

References

[1]"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus."
Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. expand/collapse author list , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L.
J. Bacteriol. 188:6841-6850(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15444.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000158 Genomic DNA. Translation: ABI76291.1.
RefSeqYP_761395.1. NC_008358.1.

3D structure databases

ProteinModelPortalQ0BYP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228405.HNE_2715.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI76291; ABI76291; HNE_2715.
GeneID4289313.
KEGGhne:HNE_2715.
PATRIC32218301. VBIHypNep17450_2720.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
KOK01887.
OMAPDITKAW.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycHNEP228405:GI69-2716-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_HYPNA
AccessionPrimary (citable) accession number: Q0BYP8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries