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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:HNE_2721
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
Proteomesi
  • UP000001959 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456591 – 447Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST447

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi228405.HNE_2721

Structurei

3D structure databases

ProteinModelPortaliQ0BYP2
SMRiQ0BYP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108EYQ Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BYP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPLTPED RANMLATIGA KSVDDFYTDV PDAARLKGKI AGLPDHQGEL
60 70 80 90 100
AVERHLTKLA AKNRSASSGP FFVGAGAYKH HVPATVDMII QRSEFLTTYT
110 120 130 140 150
PYQPEIAQGT LQTLFEFQTQ VASLTAMDVA NASMYDGSTS CAEAAVMAAR
160 170 180 190 200
VTRRKKIILS GGLHPHYAAA TRLLAEAQGL TVVQLPVAID GEGELAKAVD
210 220 230 240 250
GETACVIGQS PNVFGTVTDL SAVADAAHGK GALLVSVFTE AVSLGLVTPP
260 270 280 290 300
GEMGADIAAG EGQSIGNGLN FGGPYVGLFS CREKLVRQMP GRLCGETVDA
310 320 330 340 350
DGKRGFVLTL STREQHIRRD KATSNICTNS GLCALAFTSH MTLLGGKGLK
360 370 380 390 400
QLAELNHEAA IELADALGAV KGVEILTPRF FNEFAIRTPM DAEAVLAMLD
410 420 430 440
EAGVVGGVRA SRLFPGDHLG DVILVAATEC TTADDIAAYT DALKEII
Length:447
Mass (Da):46,985
Last modified:October 17, 2006 - v1
Checksum:iE724A1B01F97A95B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA Translation: ABI76120.1
RefSeqiWP_011647698.1, NC_008358.1

Genome annotation databases

EnsemblBacteriaiABI76120; ABI76120; HNE_2721
KEGGihne:HNE_2721

Similar proteinsi

Entry informationi

Entry nameiGCSPA_HYPNA
AccessioniPrimary (citable) accession number: Q0BYP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health