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Q0BYP2

- GCSPA_HYPNA

UniProt

Q0BYP2 - GCSPA_HYPNA

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, HNE_2721
Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciHNEP228405:GI69-2722-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:HNE_2721
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000045659Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi228405.HNE_2721.

Structurei

3D structure databases

ProteinModelPortaliQ0BYP2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BYP2-1 [UniParc]FASTAAdd to Basket

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MRYLPLTPED RANMLATIGA KSVDDFYTDV PDAARLKGKI AGLPDHQGEL    50
AVERHLTKLA AKNRSASSGP FFVGAGAYKH HVPATVDMII QRSEFLTTYT 100
PYQPEIAQGT LQTLFEFQTQ VASLTAMDVA NASMYDGSTS CAEAAVMAAR 150
VTRRKKIILS GGLHPHYAAA TRLLAEAQGL TVVQLPVAID GEGELAKAVD 200
GETACVIGQS PNVFGTVTDL SAVADAAHGK GALLVSVFTE AVSLGLVTPP 250
GEMGADIAAG EGQSIGNGLN FGGPYVGLFS CREKLVRQMP GRLCGETVDA 300
DGKRGFVLTL STREQHIRRD KATSNICTNS GLCALAFTSH MTLLGGKGLK 350
QLAELNHEAA IELADALGAV KGVEILTPRF FNEFAIRTPM DAEAVLAMLD 400
EAGVVGGVRA SRLFPGDHLG DVILVAATEC TTADDIAAYT DALKEII 447
Length:447
Mass (Da):46,985
Last modified:October 17, 2006 - v1
Checksum:iE724A1B01F97A95B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI76120.1.
RefSeqiWP_011647698.1. NC_008358.1.
YP_761401.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI76120; ABI76120; HNE_2721.
GeneIDi4288474.
KEGGihne:HNE_2721.
PATRICi32218315. VBIHypNep17450_2727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI76120.1 .
RefSeqi WP_011647698.1. NC_008358.1.
YP_761401.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0BYP2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_2721.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI76120 ; ABI76120 ; HNE_2721 .
GeneIDi 4288474.
KEGGi hne:HNE_2721.
PATRICi 32218315. VBIHypNep17450_2727.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci HNEP228405:GI69-2722-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiGCSPA_HYPNA
AccessioniPrimary (citable) accession number: Q0BYP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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