Q0BYP2 (GCSPA_HYPNA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	HNE_2721

Organism

Hyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP]

Taxonomic identifier

228405 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Hyphomonadaceae › Hyphomonas

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00712
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045659

Sequences

	Sequence		Length	Mass (Da)
	Q0BYP2 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: E724A1B01F97A95B	FASTA	447	46,985
	10 20 30 40 50 60 MRYLPLTPED RANMLATIGA KSVDDFYTDV PDAARLKGKI AGLPDHQGEL AVERHLTKLA 70 80 90 100 110 120 AKNRSASSGP FFVGAGAYKH HVPATVDMII QRSEFLTTYT PYQPEIAQGT LQTLFEFQTQ 130 140 150 160 170 180 VASLTAMDVA NASMYDGSTS CAEAAVMAAR VTRRKKIILS GGLHPHYAAA TRLLAEAQGL 190 200 210 220 230 240 TVVQLPVAID GEGELAKAVD GETACVIGQS PNVFGTVTDL SAVADAAHGK GALLVSVFTE 250 260 270 280 290 300 AVSLGLVTPP GEMGADIAAG EGQSIGNGLN FGGPYVGLFS CREKLVRQMP GRLCGETVDA 310 320 330 340 350 360 DGKRGFVLTL STREQHIRRD KATSNICTNS GLCALAFTSH MTLLGGKGLK QLAELNHEAA 370 380 390 400 410 420 IELADALGAV KGVEILTPRF FNEFAIRTPM DAEAVLAMLD EAGVVGGVRA SRLFPGDHLG 430 440 DVILVAATEC TTADDIAAYT DALKEII

References

[1]

"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus." Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L. J. Bacteriol. 188:6841-6850(2006) [PubMed: 16980487] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15444.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000158 Genomic DNA. Translation: ABI76120.1.
RefSeq	YP_761401.1. NC_008358.1.
3D structure databases
ProteinModelPortal	Q0BYP2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0BYP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4288474.
GenomeReviews	Gene locus HNE_2721 in contig CP000158_GR.
KEGG	hne:HNE_2721.
NMPDR	fig|228405.5.peg.2608.
PATRIC	32218315. VBIHypNep17450_2727.
TIGR	HNE_2721.
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HBG288345.
OMA	VANASMY.
ProtClustDB	PRK00451.
Enzyme and pathway databases
BioCyc	HNEP81032:HNE_2721-MONOMER.
Family and domain databases
HAMAP	MF_00712. GcvPA. [Tree]
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KO	K00282.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSPA_HYPNA

Accession

Primary (citable) accession number: Q0BYP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program