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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:HNE_3027
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
Proteomesi
  • UP000001959 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei71 – 91HelicalUniRule annotationAdd BLAST21
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei230 – 250HelicalUniRule annotationAdd BLAST21
Transmembranei266 – 286HelicalUniRule annotationAdd BLAST21
Transmembranei294 – 314HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21
Transmembranei375 – 395HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029911 – 397Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST397

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_3027.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BXT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYELLAADS GLFNLLNYIT FRTGAAVVTA FLVTVLFGDM LINFLRARQG
60 70 80 90 100
KGQPIRDLSL EMQLSKQGTP TMGGFLIWLG LIVGVALWGN LQNPYVWVTL
110 120 130 140 150
FVTFSYAILG FLDDYAKVTK QSTDGVSAGA RLIAGFGIAA LACAIIMGLH
160 170 180 190 200
GAHTPAGHAE WGPFNPLAEW IAGFAPQTSV EPADPNFSGG VAVPFVNNYF
210 220 230 240 250
LPLGGFFILF GMIVIVGAAN AVNFTDGLDG LAIVPMTFAA AAYAMIAYLT
260 270 280 290 300
GNFVFASYLG IQFAPGAGEL AVLLGALIGS GMGFLWYNAY PAKVFMGDTG
310 320 330 340 350
SLGLGGMLGV VAVATKHEFA LVVIGGLFVI EAVSVLTQIG WFKITKRLTG
360 370 380 390
EGKRIFLMAP LHHHFQKKNW PETRVVVRFW ILSVLFALAG LATLKLR
Length:397
Mass (Da):42,416
Last modified:October 17, 2006 - v1
Checksum:i8CC00120598C9BBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI75927.1.
RefSeqiWP_011648001.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI75927; ABI75927; HNE_3027.
KEGGihne:HNE_3027.

Similar proteinsi

Entry informationi

Entry nameiMRAY_HYPNA
AccessioniPrimary (citable) accession number: Q0BXT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families