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Q0BX04 (FTHS_HYPNA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:HNE_3316
OrganismHyphomonas neptunium (strain ATCC 15444) [Complete proteome] [HAMAP]
Taxonomic identifier228405 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300523

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0BX04 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: E275AB0122208754

FASTA55658,754
        10         20         30         40         50         60 
MASDIEIARG AKKKPIQEVA ARAGVSPENL IPYGHDKAKI SAAHLAGLAH NATGKLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTSIGLAD AMNRIGANTL LCLREPSLGP CFGMKGGATG GGLAQIVPME 

       130        140        150        160        170        180 
DINLHFTGDF HAITSAHNLL STMIDNHIHW GGEPKLEAVR TSWRRVMDMN DRSLRNIVSG 

       190        200        210        220        230        240 
LGGPGNGSPS ETGFDITVAS EVMAILCLAT DAEDLEARLA RIIVGYTSEK EAVTAADIKA 

       250        260        270        280        290        300 
TGAMMALLRD AMLPNLVQTL ENNPCLVHGG PFANIAHGCN SVMATSAALK MADYVVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF LNIKCRQAGL APDAVVLVAT IRALKMHGGL GKNDLGKVSY EALESGLENL 

       370        380        390        400        410        420 
GRHIGNLRSF GLPVIVAINR FTTDTEGEVH ALQAYCEKLG VPVSLCTHWA EGGKGTEDLA 

       430        440        450        460        470        480 
RGVTALIEKG EADFKPLYPD DMPLLEKIET VAKSIYRAGR VETTRAVRNQ LAAWEKAGFG 

       490        500        510        520        530        540 
HLPVCMAKTQ YSFSTDPALL GAPEGHVVRL REVRLAAGAG FVVAICGDIM TMPGLPRRPA 

       550 
AEHIHLNRQG QIEGLN 

« Hide

References

[1]"Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus."
Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G., Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D., Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R., Brinkac L.M. expand/collapse author list , Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G., Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N., Ward N.L.
J. Bacteriol. 188:6841-6850(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15444.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000158 Genomic DNA. Translation: ABI77946.1.
RefSeqYP_761989.1. NC_008358.1.

3D structure databases

ProteinModelPortalQ0BX04.
SMRQ0BX04. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228405.HNE_3316.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI77946; ABI77946; HNE_3316.
GeneID4290287.
KEGGhne:HNE_3316.
PATRIC32219515. VBIHypNep17450_3322.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycHNEP228405:GI69-3317-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_HYPNA
AccessionPrimary (citable) accession number: Q0BX04
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways