Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q0BX04

- FTHS_HYPNA

UniProt

Q0BX04 - FTHS_HYPNA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHNEP228405:GI69-3317-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:HNE_3316
    OrganismiHyphomonas neptunium (strain ATCC 15444)
    Taxonomic identifieri228405 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
    ProteomesiUP000001959: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300523Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi228405.HNE_3316.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BX04.
    SMRiQ0BX04. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0BX04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASDIEIARG AKKKPIQEVA ARAGVSPENL IPYGHDKAKI SAAHLAGLAH    50
    NATGKLILVT AINPTPAGEG KTTTSIGLAD AMNRIGANTL LCLREPSLGP 100
    CFGMKGGATG GGLAQIVPME DINLHFTGDF HAITSAHNLL STMIDNHIHW 150
    GGEPKLEAVR TSWRRVMDMN DRSLRNIVSG LGGPGNGSPS ETGFDITVAS 200
    EVMAILCLAT DAEDLEARLA RIIVGYTSEK EAVTAADIKA TGAMMALLRD 250
    AMLPNLVQTL ENNPCLVHGG PFANIAHGCN SVMATSAALK MADYVVTEAG 300
    FGADLGAEKF LNIKCRQAGL APDAVVLVAT IRALKMHGGL GKNDLGKVSY 350
    EALESGLENL GRHIGNLRSF GLPVIVAINR FTTDTEGEVH ALQAYCEKLG 400
    VPVSLCTHWA EGGKGTEDLA RGVTALIEKG EADFKPLYPD DMPLLEKIET 450
    VAKSIYRAGR VETTRAVRNQ LAAWEKAGFG HLPVCMAKTQ YSFSTDPALL 500
    GAPEGHVVRL REVRLAAGAG FVVAICGDIM TMPGLPRRPA AEHIHLNRQG 550
    QIEGLN 556
    Length:556
    Mass (Da):58,754
    Last modified:October 17, 2006 - v1
    Checksum:iE275AB0122208754
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77946.1.
    RefSeqiWP_011648284.1. NC_008358.1.
    YP_761989.1. NC_008358.1.

    Genome annotation databases

    EnsemblBacteriaiABI77946; ABI77946; HNE_3316.
    GeneIDi4290287.
    KEGGihne:HNE_3316.
    PATRICi32219515. VBIHypNep17450_3322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77946.1 .
    RefSeqi WP_011648284.1. NC_008358.1.
    YP_761989.1. NC_008358.1.

    3D structure databases

    ProteinModelPortali Q0BX04.
    SMRi Q0BX04. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228405.HNE_3316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI77946 ; ABI77946 ; HNE_3316 .
    GeneIDi 4290287.
    KEGGi hne:HNE_3316.
    PATRICi 32219515. VBIHypNep17450_3322.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci HNEP228405:GI69-3317-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15444.

    Entry informationi

    Entry nameiFTHS_HYPNA
    AccessioniPrimary (citable) accession number: Q0BX04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3