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Q0BX04

- FTHS_HYPNA

UniProt

Q0BX04 - FTHS_HYPNA

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHNEP228405:GI69-3317-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:HNE_3316
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300523Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_3316.

Structurei

3D structure databases

ProteinModelPortaliQ0BX04.
SMRiQ0BX04. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BX04-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASDIEIARG AKKKPIQEVA ARAGVSPENL IPYGHDKAKI SAAHLAGLAH
60 70 80 90 100
NATGKLILVT AINPTPAGEG KTTTSIGLAD AMNRIGANTL LCLREPSLGP
110 120 130 140 150
CFGMKGGATG GGLAQIVPME DINLHFTGDF HAITSAHNLL STMIDNHIHW
160 170 180 190 200
GGEPKLEAVR TSWRRVMDMN DRSLRNIVSG LGGPGNGSPS ETGFDITVAS
210 220 230 240 250
EVMAILCLAT DAEDLEARLA RIIVGYTSEK EAVTAADIKA TGAMMALLRD
260 270 280 290 300
AMLPNLVQTL ENNPCLVHGG PFANIAHGCN SVMATSAALK MADYVVTEAG
310 320 330 340 350
FGADLGAEKF LNIKCRQAGL APDAVVLVAT IRALKMHGGL GKNDLGKVSY
360 370 380 390 400
EALESGLENL GRHIGNLRSF GLPVIVAINR FTTDTEGEVH ALQAYCEKLG
410 420 430 440 450
VPVSLCTHWA EGGKGTEDLA RGVTALIEKG EADFKPLYPD DMPLLEKIET
460 470 480 490 500
VAKSIYRAGR VETTRAVRNQ LAAWEKAGFG HLPVCMAKTQ YSFSTDPALL
510 520 530 540 550
GAPEGHVVRL REVRLAAGAG FVVAICGDIM TMPGLPRRPA AEHIHLNRQG

QIEGLN
Length:556
Mass (Da):58,754
Last modified:October 17, 2006 - v1
Checksum:iE275AB0122208754
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI77946.1.
RefSeqiWP_011648284.1. NC_008358.1.
YP_761989.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI77946; ABI77946; HNE_3316.
GeneIDi4290287.
KEGGihne:HNE_3316.
PATRICi32219515. VBIHypNep17450_3322.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI77946.1 .
RefSeqi WP_011648284.1. NC_008358.1.
YP_761989.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0BX04.
SMRi Q0BX04. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_3316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI77946 ; ABI77946 ; HNE_3316 .
GeneIDi 4290287.
KEGGi hne:HNE_3316.
PATRICi 32219515. VBIHypNep17450_3322.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci HNEP228405:GI69-3317-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiFTHS_HYPNA
AccessioniPrimary (citable) accession number: Q0BX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 17, 2006
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3