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Q0BWM9

- PNP_HYPNA

UniProt

Q0BWM9 - PNP_HYPNA

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, HNE_3441
Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: JCVI

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: JCVI
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciHNEP228405:GI69-3442-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:HNE_3441
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329682Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_3441.

Structurei

3D structure databases

ProteinModelPortaliQ0BWM9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KH
Add
BLAST
Domaini624 – 69269S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiHGNFKSN.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BWM9-1 [UniParc]FASTAAdd to Basket

« Hide

MFNKQSVSLE WAGRTLTIET GQVARQADGA VMVQYGDTIV LATAVFAKEA    50
KPGQDFFPLT VNYQEKYFAS GRIPGGFFKR EGRPTEKETL TSRLIDRPIR 100
PLFVDGFKHE VQVVVTTLSY DLENDADIIA LVGASAALVL SGAPFMGPIG 150
AARVGYKDGQ YIINPTIAEL EESELDLVVA GTTDAVMMVE SQAAELSEDV 200
MLGAVVAGHD AMQPVIDAII ALAEKAAKEP FAYEPPDHSA ALKSVIDTVG 250
ADLSKAYKIT AKGERYAAIG AAKDKAKAAL LGTDEAPGVM TPEVFKTVFK 300
EAEASVVRGD ILKTGQRIDG RKLDQIRPIV AEAGFLPRTH GSSLFTRGET 350
QAICVATLGT SDDEQYIDGL DGTKKEKFML HYNFPPYSVG ETGRMGGAGR 400
REIGHGKLAW RALKAVLPKH EDFPYTIRMV SEITESNGSS SMATVCGCSL 450
AMMDAGVPLT RPVSGIAMGL ILEGSEFAVL SDILGDEDHL GDMDFKVAGT 500
ENGVTSLQMD IKVAGITKDI MGKALEQAKG GRMHILGEMG KALTASRGQL 550
SENAPQMEII KVPTDKIRDV IGSGGKVIRG IVDETGAKVN IDDDGTVQIS 600
AMDRKSIDAA IKMIKGITAE AEVGEIYEGK VVSMKDFGIF VNFFGPKDGL 650
VHVSQMANKR IGHPKEMVKE GDKVWVKLMG FDERGKVRLS MKVVDQETGK 700
ELAEEAGDDA SED 713
Length:713
Mass (Da):76,422
Last modified:October 17, 2006 - v1
Checksum:iFDDAF00AA87ED40D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI76481.1.
RefSeqiYP_762114.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI76481; ABI76481; HNE_3441.
GeneIDi4288000.
KEGGihne:HNE_3441.
PATRICi32219759. VBIHypNep17450_3444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI76481.1 .
RefSeqi YP_762114.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0BWM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_3441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI76481 ; ABI76481 ; HNE_3441 .
GeneIDi 4288000.
KEGGi hne:HNE_3441.
PATRICi 32219759. VBIHypNep17450_3444.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi HGNFKSN.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci HNEP228405:GI69-3442-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiPNP_HYPNA
AccessioniPrimary (citable) accession number: Q0BWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 17, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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