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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:HNE_3477
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
Proteomesi
  • UP000001959 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000185981 – 211N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST211

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_3477.

Structurei

3D structure databases

ProteinModelPortaliQ0BWJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB. Bacteria.
COG0135. LUCA.
HOGENOMiHOG000161598.
KOiK01817.
OMAiCGFIFHP.
OrthoDBiPOG091H01PA.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BWJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVKICGLK DPDMVAFAAR EGADWVGFVF APSVRQVTLA AAETLLLSVG
60 70 80 90 100
KATPVALMVD PSDAEAQAVA ALGFPILQLH GQETPARAAE LKSLTGCAIW
110 120 130 140 150
KAIGVQTRDN LGQIGTFPDI DGLLLDAKPP EGATIAGGHG AAFDWSILKG
160 170 180 190 200
WTAPKPWLLA GGLTPENVAE AIAATGAPGV DVSSGVERIR GLKDRELVRA
210
FIRAAKASEQ P
Length:211
Mass (Da):21,856
Last modified:October 17, 2006 - v1
Checksum:i7C5FE3AEC07C87F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI75671.1.
RefSeqiWP_011648443.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI75671; ABI75671; HNE_3477.
KEGGihne:HNE_3477.
PATRICi32219837. VBIHypNep17450_3482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI75671.1.
RefSeqiWP_011648443.1. NC_008358.1.

3D structure databases

ProteinModelPortaliQ0BWJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228405.HNE_3477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI75671; ABI75671; HNE_3477.
KEGGihne:HNE_3477.
PATRICi32219837. VBIHypNep17450_3482.

Phylogenomic databases

eggNOGiENOG4108ZGB. Bacteria.
COG0135. LUCA.
HOGENOMiHOG000161598.
KOiK01817.
OMAiCGFIFHP.
OrthoDBiPOG091H01PA.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPF_HYPNA
AccessioniPrimary (citable) accession number: Q0BWJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.