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Q0BWI1

- ASSY_HYPNA

UniProt

Q0BWI1 - ASSY_HYPNA

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei94 – 941CitrullineUniRule annotation
Binding sitei99 – 991CitrullineUniRule annotation
Binding sitei124 – 1241ATP; via amide nitrogenUniRule annotation
Binding sitei126 – 1261AspartateUniRule annotation
Binding sitei130 – 1301AspartateUniRule annotation
Binding sitei130 – 1301CitrullineUniRule annotation
Binding sitei131 – 1311AspartateUniRule annotation
Binding sitei134 – 1341CitrullineUniRule annotation
Binding sitei185 – 1851CitrullineUniRule annotation
Binding sitei194 – 1941CitrullineUniRule annotation
Binding sitei270 – 2701CitrullineUniRule annotation
Binding sitei282 – 2821CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHNEP228405:GI69-3492-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:HNE_3491
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Argininosuccinate synthasePRO_0000263932Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi228405.HNE_3491.

Structurei

3D structure databases

ProteinModelPortaliQ0BWI1.
SMRiQ0BWI1. Positions 10-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiGIKSKFD.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BWI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNAASAPKK VVLAYSGGLD TSIILKWLQV EFGCEVVTFT ADLGQGEELE
60 70 80 90 100
PARKKALAAG VKPENIFIED VREEFVRDFV FPMFRANAVY EGVYLLGTSI
110 120 130 140 150
ARPLIAKRQI EIADMVGADA VCHGATGKGN DQVRFELGYY GLNPDIKVIA
160 170 180 190 200
PWRDWAFKSR TDLLKFAEEH GIEIAKDKRG EAPFSVDANL LHSSSEGKVL
210 220 230 240 250
ENPAEPAPEF VHMRTVSPED APDQAEVITI SFEKGDAVAI NGEAMSPATL
260 270 280 290 300
LTALNAYGKK HGIGRLDLLE NRFVGMKSRG IYETPGGTIL LVAHRGIEQA
310 320 330 340 350
TLDRGAAHLK DELMPKYAEL IYNGFWWSPE REMLQAAIDH SQRWVTGDVT
360 370 380 390 400
MKLYKGNAYL IGRSSPYSLY SEKIVTFEDD HGAYDQKDAA GFIKLNALRL
410
RLLAGRDRKF GKN
Length:413
Mass (Da):45,656
Last modified:October 17, 2006 - v1
Checksum:i197676852BE6F50B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI77474.1.
RefSeqiYP_762162.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI77474; ABI77474; HNE_3491.
GeneIDi4288392.
KEGGihne:HNE_3491.
PATRICi32219865. VBIHypNep17450_3495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000158 Genomic DNA. Translation: ABI77474.1 .
RefSeqi YP_762162.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0BWI1.
SMRi Q0BWI1. Positions 10-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_3491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI77474 ; ABI77474 ; HNE_3491 .
GeneIDi 4288392.
KEGGi hne:HNE_3491.
PATRICi 32219865. VBIHypNep17450_3495.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi GIKSKFD.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci HNEP228405:GI69-3492-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiASSY_HYPNA
AccessioniPrimary (citable) accession number: Q0BWI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 17, 2006
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3