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Q0BWI1

- ASSY_HYPNA

UniProt

Q0BWI1 - ASSY_HYPNA

Protein

Argininosuccinate synthase

Gene

argG

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei94 – 941CitrullineUniRule annotation
    Binding sitei99 – 991CitrullineUniRule annotation
    Binding sitei124 – 1241ATP; via amide nitrogenUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei130 – 1301AspartateUniRule annotation
    Binding sitei130 – 1301CitrullineUniRule annotation
    Binding sitei131 – 1311AspartateUniRule annotation
    Binding sitei134 – 1341CitrullineUniRule annotation
    Binding sitei185 – 1851CitrullineUniRule annotation
    Binding sitei194 – 1941CitrullineUniRule annotation
    Binding sitei270 – 2701CitrullineUniRule annotation
    Binding sitei282 – 2821CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 229ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHNEP228405:GI69-3492-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:HNE_3491
    OrganismiHyphomonas neptunium (strain ATCC 15444)
    Taxonomic identifieri228405 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
    ProteomesiUP000001959: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Argininosuccinate synthasePRO_0000263932Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi228405.HNE_3491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BWI1.
    SMRiQ0BWI1. Positions 10-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiGIKSKFD.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0BWI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNAASAPKK VVLAYSGGLD TSIILKWLQV EFGCEVVTFT ADLGQGEELE    50
    PARKKALAAG VKPENIFIED VREEFVRDFV FPMFRANAVY EGVYLLGTSI 100
    ARPLIAKRQI EIADMVGADA VCHGATGKGN DQVRFELGYY GLNPDIKVIA 150
    PWRDWAFKSR TDLLKFAEEH GIEIAKDKRG EAPFSVDANL LHSSSEGKVL 200
    ENPAEPAPEF VHMRTVSPED APDQAEVITI SFEKGDAVAI NGEAMSPATL 250
    LTALNAYGKK HGIGRLDLLE NRFVGMKSRG IYETPGGTIL LVAHRGIEQA 300
    TLDRGAAHLK DELMPKYAEL IYNGFWWSPE REMLQAAIDH SQRWVTGDVT 350
    MKLYKGNAYL IGRSSPYSLY SEKIVTFEDD HGAYDQKDAA GFIKLNALRL 400
    RLLAGRDRKF GKN 413
    Length:413
    Mass (Da):45,656
    Last modified:October 17, 2006 - v1
    Checksum:i197676852BE6F50B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77474.1.
    RefSeqiWP_011648456.1. NC_008358.1.
    YP_762162.1. NC_008358.1.

    Genome annotation databases

    EnsemblBacteriaiABI77474; ABI77474; HNE_3491.
    GeneIDi4288392.
    KEGGihne:HNE_3491.
    PATRICi32219865. VBIHypNep17450_3495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77474.1 .
    RefSeqi WP_011648456.1. NC_008358.1.
    YP_762162.1. NC_008358.1.

    3D structure databases

    ProteinModelPortali Q0BWI1.
    SMRi Q0BWI1. Positions 10-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228405.HNE_3491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI77474 ; ABI77474 ; HNE_3491 .
    GeneIDi 4288392.
    KEGGi hne:HNE_3491.
    PATRICi 32219865. VBIHypNep17450_3495.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi GIKSKFD.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci HNEP228405:GI69-3492-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15444.

    Entry informationi

    Entry nameiASSY_HYPNA
    AccessioniPrimary (citable) accession number: Q0BWI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3