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Q0BWI1

- ASSY_HYPNA

UniProt

Q0BWI1 - ASSY_HYPNA

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Protein

Argininosuccinate synthase

Gene
argG, HNE_3491
Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei94 – 941Citrulline By similarity
Binding sitei99 – 991Citrulline By similarity
Binding sitei124 – 1241ATP; via amide nitrogen By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei130 – 1301Aspartate By similarity
Binding sitei130 – 1301Citrulline By similarity
Binding sitei131 – 1311Aspartate By similarity
Binding sitei134 – 1341Citrulline By similarity
Binding sitei185 – 1851Citrulline By similarity
Binding sitei194 – 1941Citrulline By similarity
Binding sitei270 – 2701Citrulline By similarity
Binding sitei282 – 2821Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHNEP228405:GI69-3492-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:HNE_3491
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Argininosuccinate synthaseUniRule annotationPRO_0000263932Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi228405.HNE_3491.

Structurei

3D structure databases

ProteinModelPortaliQ0BWI1.
SMRiQ0BWI1. Positions 10-408.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiGIKSKFD.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BWI1-1 [UniParc]FASTAAdd to Basket

« Hide

MSNAASAPKK VVLAYSGGLD TSIILKWLQV EFGCEVVTFT ADLGQGEELE    50
PARKKALAAG VKPENIFIED VREEFVRDFV FPMFRANAVY EGVYLLGTSI 100
ARPLIAKRQI EIADMVGADA VCHGATGKGN DQVRFELGYY GLNPDIKVIA 150
PWRDWAFKSR TDLLKFAEEH GIEIAKDKRG EAPFSVDANL LHSSSEGKVL 200
ENPAEPAPEF VHMRTVSPED APDQAEVITI SFEKGDAVAI NGEAMSPATL 250
LTALNAYGKK HGIGRLDLLE NRFVGMKSRG IYETPGGTIL LVAHRGIEQA 300
TLDRGAAHLK DELMPKYAEL IYNGFWWSPE REMLQAAIDH SQRWVTGDVT 350
MKLYKGNAYL IGRSSPYSLY SEKIVTFEDD HGAYDQKDAA GFIKLNALRL 400
RLLAGRDRKF GKN 413
Length:413
Mass (Da):45,656
Last modified:October 17, 2006 - v1
Checksum:i197676852BE6F50B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77474.1.
RefSeqiWP_011648456.1. NC_008358.1.
YP_762162.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI77474; ABI77474; HNE_3491.
GeneIDi4288392.
KEGGihne:HNE_3491.
PATRICi32219865. VBIHypNep17450_3495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77474.1 .
RefSeqi WP_011648456.1. NC_008358.1.
YP_762162.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0BWI1.
SMRi Q0BWI1. Positions 10-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228405.HNE_3491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI77474 ; ABI77474 ; HNE_3491 .
GeneIDi 4288392.
KEGGi hne:HNE_3491.
PATRICi 32219865. VBIHypNep17450_3495.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi GIKSKFD.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci HNEP228405:GI69-3492-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiASSY_HYPNA
AccessioniPrimary (citable) accession number: Q0BWI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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