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Q0BWB5

- SYL_HYPNA

UniProt

Q0BWB5 - SYL_HYPNA

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Protein
Leucine--tRNA ligase
Gene
leuS, HNE_3557
Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHNEP228405:GI69-3558-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:HNE_3557
OrganismiHyphomonas neptunium (strain ATCC 15444)
Taxonomic identifieri228405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
ProteomesiUP000001959: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 855855Leucine--tRNA ligaseUniRule annotation
PRO_0000334764Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228405.HNE_3557.

Structurei

3D structure databases

ProteinModelPortaliQ0BWB5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BWB5-1 [UniParc]FASTAAdd to Basket

« Hide

MATRYDPQSA EPRWRDAWEK ADIFRTKAPK DAPGAPKAFV LEMFPYPSGR    50
LHMGHVRNYA MGDVVARHKR AKGYNVLHPM GWDAFGMPAE NAAMERKVHP 100
GKWTYANIES MKAQFRKLGL SLDWSREFAT CDPDYYGAQQ ALFLKLMDKG 150
LVYRKASKVN WDPVDNTVLA NEQVIDGRGW RSGAPVEQRE LTQWFFKITA 200
YADDLLEAVQ KLERWPEKVR TMQANWIGRS EGLEMTFAFD GERPAGFEDG 250
ISVFTTRPDT LFGASFVALS PDHPLTLQLA EKSDALQAFR AKCAQIGTSE 300
EAIEKAEKLG FDTGLTVAHP FEPGRTVPVW VANFVLMGYG TGAIFGCPAH 350
DQRDLDFARK FGLDVFPVVL PPGADAAAFE VGIEAYTGPG HIYKSGFLDG 400
LSIDDAKRAA IAKIEAAGQG EGKVNYRLRD WGVSRQRYWG CPIPVVHCED 450
CGVVGVPAAD LPVRLPEDVT FDVPGNPLDR HPDWKHVDCP KCGKPARRET 500
DTLDTFVDSS WYYARFASVS DPEERAYWLP VDQYIGGVEH AVLHLLYSRF 550
FSRAMRDVGE LDLPSGEPFA GLFTQGMVTH ETYRSEGGTW LEPSAVERKD 600
GQVFEIATGK PVKVGAIEKM SKSKKNTVDP DAIVATYGAD VARWFVLSDS 650
PPERDVEWTQ SGAEGAARFV QRVWSFVDSL PETGPFPAPG SDDVSTALRK 700
SNHKAVAAID RAIEEFRFNS AIATIHEWVN ALKKTESDPA TLGARAEGAD 750
MLARCLVPFM PHLAEACWER LGQTSLVSQA MWPKIDASLV VDDTVTLAVQ 800
VNGKRRAEIT VAKDMAPDAV EAAAKALPDV ASFIAGKSVK KTIVVPGRIV 850
NIVVA 855
Length:855
Mass (Da):94,333
Last modified:October 17, 2006 - v1
Checksum:i40A93E3F4848CAFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77585.1.
RefSeqiWP_011648522.1. NC_008358.1.
YP_762228.1. NC_008358.1.

Genome annotation databases

EnsemblBacteriaiABI77585; ABI77585; HNE_3557.
GeneIDi4289011.
KEGGihne:HNE_3557.
PATRICi32220001. VBIHypNep17450_3563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000158 Genomic DNA. Translation: ABI77585.1 .
RefSeqi WP_011648522.1. NC_008358.1.
YP_762228.1. NC_008358.1.

3D structure databases

ProteinModelPortali Q0BWB5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 228405.HNE_3557.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI77585 ; ABI77585 ; HNE_3557 .
GeneIDi 4289011.
KEGGi hne:HNE_3557.
PATRICi 32220001. VBIHypNep17450_3563.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HNEP228405:GI69-3558-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15444.

Entry informationi

Entry nameiSYL_HYPNA
AccessioniPrimary (citable) accession number: Q0BWB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi