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Q0BWB5

- SYL_HYPNA

UniProt

Q0BWB5 - SYL_HYPNA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Hyphomonas neptunium (strain ATCC 15444)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHNEP228405:GI69-3558-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:HNE_3557
    OrganismiHyphomonas neptunium (strain ATCC 15444)
    Taxonomic identifieri228405 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesHyphomonadaceaeHyphomonas
    ProteomesiUP000001959: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 855855Leucine--tRNA ligasePRO_0000334764Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi228405.HNE_3557.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BWB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 5511"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0BWB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATRYDPQSA EPRWRDAWEK ADIFRTKAPK DAPGAPKAFV LEMFPYPSGR    50
    LHMGHVRNYA MGDVVARHKR AKGYNVLHPM GWDAFGMPAE NAAMERKVHP 100
    GKWTYANIES MKAQFRKLGL SLDWSREFAT CDPDYYGAQQ ALFLKLMDKG 150
    LVYRKASKVN WDPVDNTVLA NEQVIDGRGW RSGAPVEQRE LTQWFFKITA 200
    YADDLLEAVQ KLERWPEKVR TMQANWIGRS EGLEMTFAFD GERPAGFEDG 250
    ISVFTTRPDT LFGASFVALS PDHPLTLQLA EKSDALQAFR AKCAQIGTSE 300
    EAIEKAEKLG FDTGLTVAHP FEPGRTVPVW VANFVLMGYG TGAIFGCPAH 350
    DQRDLDFARK FGLDVFPVVL PPGADAAAFE VGIEAYTGPG HIYKSGFLDG 400
    LSIDDAKRAA IAKIEAAGQG EGKVNYRLRD WGVSRQRYWG CPIPVVHCED 450
    CGVVGVPAAD LPVRLPEDVT FDVPGNPLDR HPDWKHVDCP KCGKPARRET 500
    DTLDTFVDSS WYYARFASVS DPEERAYWLP VDQYIGGVEH AVLHLLYSRF 550
    FSRAMRDVGE LDLPSGEPFA GLFTQGMVTH ETYRSEGGTW LEPSAVERKD 600
    GQVFEIATGK PVKVGAIEKM SKSKKNTVDP DAIVATYGAD VARWFVLSDS 650
    PPERDVEWTQ SGAEGAARFV QRVWSFVDSL PETGPFPAPG SDDVSTALRK 700
    SNHKAVAAID RAIEEFRFNS AIATIHEWVN ALKKTESDPA TLGARAEGAD 750
    MLARCLVPFM PHLAEACWER LGQTSLVSQA MWPKIDASLV VDDTVTLAVQ 800
    VNGKRRAEIT VAKDMAPDAV EAAAKALPDV ASFIAGKSVK KTIVVPGRIV 850
    NIVVA 855
    Length:855
    Mass (Da):94,333
    Last modified:October 17, 2006 - v1
    Checksum:i40A93E3F4848CAFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77585.1.
    RefSeqiWP_011648522.1. NC_008358.1.
    YP_762228.1. NC_008358.1.

    Genome annotation databases

    EnsemblBacteriaiABI77585; ABI77585; HNE_3557.
    GeneIDi4289011.
    KEGGihne:HNE_3557.
    PATRICi32220001. VBIHypNep17450_3563.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000158 Genomic DNA. Translation: ABI77585.1 .
    RefSeqi WP_011648522.1. NC_008358.1.
    YP_762228.1. NC_008358.1.

    3D structure databases

    ProteinModelPortali Q0BWB5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228405.HNE_3557.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI77585 ; ABI77585 ; HNE_3557 .
    GeneIDi 4289011.
    KEGGi hne:HNE_3557.
    PATRICi 32220001. VBIHypNep17450_3563.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HNEP228405:GI69-3558-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15444.

    Entry informationi

    Entry nameiSYL_HYPNA
    AccessioniPrimary (citable) accession number: Q0BWB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3