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Q0BW99

- SYL_GRABC

UniProt

Q0BW99 - SYL_GRABC

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Protein
Leucine--tRNA ligase
Gene
leuS, GbCGDNIH1_0005
Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei634 – 6341ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGBET391165:GHON-5-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:GbCGDNIH1_0005
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
ProteomesiUP000001963: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Leucine--tRNA ligaseUniRule annotation
PRO_0000334761Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0005.

Structurei

3D structure databases

ProteinModelPortaliQ0BW99.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi57 – 6711"HIGH" regionUniRule annotation
Add
BLAST
Motifi631 – 6355"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BW99-1 [UniParc]FASTAAdd to Basket

« Hide

MTDSITDLQS DQRPDRSYDF ASAERRWQLA WTERACFTVP DVPDPGARTY    50
YVLEMFPYPS GQIHMGHVRN YTLGDVVARY KRAQGYQVLH PMGWDAFGLP 100
AENAARERGV HPGQWTWNNI AAMRGELQRM GLSITWEREF ATCDPSYYGH 150
QQALFLDFLK KNLVERRESW VNWDPVDETV LANEQVIDGK GWRSGAPVER 200
KKLSQWFLRI TDYAEELLAG LDQLDRWPER VRVMQSRWIG RSEGARLRFP 250
LVEPLGDQRE IEVYTTRPDT LYGMSFVAIA ADHPVAAALA AHHPALAAFV 300
AECRSLGTSE AAIEAAEKRG FDTGLRVKHP FCDETFPVWI ANFVLMDYGT 350
GAVFGCPAHD QRDLDFARKY DLSVTPVVLP SDQDAASFTI GRKAYDGDGI 400
LFNSGPFDGL TPDAARREAI TRLEAMGWGQ GVTNWRLRDW GVSRQRYWGC 450
PIPIIHCDQC GPVPVPADQL PVTLPEDVTF DRPGNPLDHH PSWKHVTCPS 500
CGAAAVRETD TFDTFVDSSW YFARFASPHA HVPVLKEAAQ NWLPVDQYIG 550
GIEHAILHLL YARFFTRAMA DTGHVPVREP FAGLFTQGMV THESYRAADG 600
RWLSPVEVTR HGETVVETAT GEPVQVGRGE KMSKSKRNTV APGEIFNRYG 650
ADAARWFILS DNPPERDMEW TDAGAVGAYR FVQRLYRLAE AVARIAKEET 700
NRDDASSDAA MTLRRMTHRT VAAVTEALEG FNFNVAVARV YEFANALTEA 750
EKKAAEPGMT AARVEAITLL SRIIAPMMPH LAEEMATLIE QGPKLVAEQV 800
WPSADPALLV VQSVTIAIQV MGKLRATLDI SPDADQDSVI AQAEADPNVV 850
RALEGKRVVK RIYVPNRIVN FVIAG 875
Length:875
Mass (Da):97,795
Last modified:October 17, 2006 - v1
Checksum:i91357A96A7461C7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI60903.1.
RefSeqiYP_743826.1. NC_008343.1.

Genome annotation databases

EnsemblBacteriaiABI60903; ABI60903; GbCGDNIH1_0005.
GeneIDi4274530.
KEGGigbe:GbCGDNIH1_0005.
PATRICi22076005. VBIGraBet83793_0005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI60903.1 .
RefSeqi YP_743826.1. NC_008343.1.

3D structure databases

ProteinModelPortali Q0BW99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391165.GbCGDNIH1_0005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI60903 ; ABI60903 ; GbCGDNIH1_0005 .
GeneIDi 4274530.
KEGGi gbe:GbCGDNIH1_0005.
PATRICi 22076005. VBIGraBet83793_0005.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GBET391165:GHON-5-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
    Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
    J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1260 / CGDNIH1.

Entry informationi

Entry nameiSYL_GRABC
AccessioniPrimary (citable) accession number: Q0BW99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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