fhs

Functionⁱ

Catalytic activityⁱ

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayⁱ: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	81 – 88	ATPUniRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
formate-tetrahydrofolate ligase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

tetrahydrofolate interconversion Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Ligase
Biological process	One-carbon metabolism
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00193.

UniPathwayⁱ

UPA00193.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation) Alternative name(s): Formyltetrahydrofolate synthetaseUniRule annotation Short name: FHSUniRule annotation Short name: FTHFSUniRule annotation
Gene namesⁱ	Name:fhsUniRule annotation Ordered Locus Names:GbCGDNIH1_0047
Organismⁱ	Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifierⁱ	391165 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter › Granulibacter bethesdensis
Proteomesⁱ	UP000001963 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000293036	1 – 572	Formate--tetrahydrofolate ligaseAdd BLAST		572

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	391165.GbCGDNIH1_0047.

STRINGⁱ

391165.GbCGDNIH1_0047.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q0BW57.
SMRⁱ	Q0BW57.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CKU. Bacteria. COG2759. LUCA.
HOGENOMⁱ	HOG000040280.
KEGG Orthology (KO) More...KOⁱ	K01938.
OMAⁱ	CGEIMTM.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01S8.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00477. FTHFS. 1 hit.
HAMAPⁱ	MF_01543. FTHFS. 1 hit.
InterProⁱ	View protein in InterPro IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01268. FTHFS. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q0BW57-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTEANKPRG NQHQEAKSDA EIAQAAFMRP IVDVAAEKLG IAAEHLAPYG 
        60         70         80         90        100
HYKAKIDLNY LSSLDSRPDG KLVLVTAISP TPAGEGKTTT TVGLTDALNH 
       110        120        130        140        150
IGKKAVACLR EPSLGPCFGV KGGAAGGGYA QVVPMEDINL HFTGDFHAIG 
       160        170        180        190        200
AANNLLAALI DNHVYWGNEL GIDPRRIGWR RAVDMNDRAL RSIVSSLGGV 
       210        220        230        240        250
SNGYPREDGF DITVASEVMA IFCLATDLDD LQRRLGNIIV GHTKDRKPIR 
       260        270        280        290        300
ASELSAAGSM AVLLKDAIAP NLVQTLEHNP AFIHGGPFAN IAHGCNSVIA 
       310        320        330        340        350
TRAALKLSDY VVTEAGFGAD LGAEKFFDIK CRKAGLSPSA VVIVATVRAL 
       360        370        380        390        400
KMHGGVAKDA LKTENVEAVQ KGFANLERHI QNVRKFGVPV VVGVNKFSAD 
       410        420        430        440        450
TDAEFQMLHD LCAKMGVPCV SSDHWANGGA GAADLAHEVV KLVEGGSADF 
       460        470        480        490        500
KPLYPEDMPL WDKLRTIATE IYGASDITAD AAVRKRFDEL QKEGFGHLPI 
       510        520        530        540        550
CVAKTQYSFS TDANLRGAPS GHVIPVRDLR LSAGAEFVVA ICGDIMTMPG 
       560        570 
LPKVPAANAI RLASNGTIAG LF

Length:572

Mass (Da):60,606

Last modified:October 17, 2006 - v1

Checksum:ⁱ6D804024DA30ADD2

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000394 Genomic DNA. Translation: ABI60945.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011630755.1. NC_008343.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABI60945; ABI60945; GbCGDNIH1_0047.
GeneIDⁱ	31474757.
KEGGⁱ	gbe:GbCGDNIH1_0047.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000394 Genomic DNA. Translation: ABI60945.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_011630755.1. NC_008343.1.

3D structure databases

ProteinModelPortalⁱ	Q0BW57.
SMRⁱ	Q0BW57.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	391165.GbCGDNIH1_0047.

STRINGⁱ

391165.GbCGDNIH1_0047.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABI60945; ABI60945; GbCGDNIH1_0047.
GeneIDⁱ	31474757.
KEGGⁱ	gbe:GbCGDNIH1_0047.

Phylogenomic databases

eggNOGⁱ	ENOG4105CKU. Bacteria. COG2759. LUCA.
HOGENOMⁱ	HOG000040280.
KEGG Orthology (KO) More...KOⁱ	K01938.
OMAⁱ	CGEIMTM.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01S8.

Enzyme and pathway databases

UniPathwayⁱ	UPA00193.

UniPathwayⁱ

UPA00193.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00477. FTHFS. 1 hit.
HAMAPⁱ	MF_01543. FTHFS. 1 hit.
InterProⁱ	View protein in InterPro IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01268. FTHFS. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FTHS_GRABC
Accessionⁱ	Q0BW57Primary (citable) accession number: Q0BW57
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
	Last sequence update:	October 17, 2006
	Last modified:	July 5, 2017
	This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q0BW57 (FTHS_GRABC)

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Formate--tetrahydrofolate ligase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate interconversion

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: tetrahydrofolate interconversion

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ