UniProtKB - Q0BW57 (FTHS_GRABC)
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Protein
Formate--tetrahydrofolate ligase
Gene
fhs
Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Functioni
Catalytic activityi
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation
: tetrahydrofolate interconversion Pathwayi
This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 81 – 88 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- formate-tetrahydrofolate ligase activity Source: UniProtKB-EC
GO - Biological processi
- tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Ligase |
Biological process | One-carbon metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | GBET391165:G1G6T-47-MONOMER. |
UniPathwayi | UPA00193. |
Names & Taxonomyi
Protein namesi | Recommended name: Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)Alternative name(s): Formyltetrahydrofolate synthetaseUniRule annotation Short name: FHSUniRule annotation Short name: FTHFSUniRule annotation |
Gene namesi | Name:fhsUniRule annotation Ordered Locus Names:GbCGDNIH1_0047 |
Organismi | Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) |
Taxonomic identifieri | 391165 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000293036 | 1 – 572 | Formate--tetrahydrofolate ligaseAdd BLAST | 572 |
Structurei
3D structure databases
ProteinModelPortali | Q0BW57. |
SMRi | Q0BW57. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105CKU. Bacteria. COG2759. LUCA. |
HOGENOMi | HOG000040280. |
KOi | K01938. |
OMAi | CGEIMTM. |
OrthoDBi | POG091H01S8. |
Family and domain databases
CDDi | cd00477. FTHFS. 1 hit. |
HAMAPi | MF_01543. FTHFS. 1 hit. |
InterProi | View protein in InterPro IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. IPR027417. P-loop_NTPase. |
Pfami | View protein in Pfam PF01268. FTHFS. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q0BW57-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTEANKPRG NQHQEAKSDA EIAQAAFMRP IVDVAAEKLG IAAEHLAPYG
60 70 80 90 100
HYKAKIDLNY LSSLDSRPDG KLVLVTAISP TPAGEGKTTT TVGLTDALNH
110 120 130 140 150
IGKKAVACLR EPSLGPCFGV KGGAAGGGYA QVVPMEDINL HFTGDFHAIG
160 170 180 190 200
AANNLLAALI DNHVYWGNEL GIDPRRIGWR RAVDMNDRAL RSIVSSLGGV
210 220 230 240 250
SNGYPREDGF DITVASEVMA IFCLATDLDD LQRRLGNIIV GHTKDRKPIR
260 270 280 290 300
ASELSAAGSM AVLLKDAIAP NLVQTLEHNP AFIHGGPFAN IAHGCNSVIA
310 320 330 340 350
TRAALKLSDY VVTEAGFGAD LGAEKFFDIK CRKAGLSPSA VVIVATVRAL
360 370 380 390 400
KMHGGVAKDA LKTENVEAVQ KGFANLERHI QNVRKFGVPV VVGVNKFSAD
410 420 430 440 450
TDAEFQMLHD LCAKMGVPCV SSDHWANGGA GAADLAHEVV KLVEGGSADF
460 470 480 490 500
KPLYPEDMPL WDKLRTIATE IYGASDITAD AAVRKRFDEL QKEGFGHLPI
510 520 530 540 550
CVAKTQYSFS TDANLRGAPS GHVIPVRDLR LSAGAEFVVA ICGDIMTMPG
560 570
LPKVPAANAI RLASNGTIAG LF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000394 Genomic DNA. Translation: ABI60945.1. |
RefSeqi | WP_011630755.1. NC_008343.2. |
Genome annotation databases
EnsemblBacteriai | ABI60945; ABI60945; GbCGDNIH1_0047. |
GeneIDi | 31474757. |
KEGGi | gbe:GbCGDNIH1_0047. |
Similar proteinsi
Entry informationi
Entry namei | FTHS_GRABC | |
Accessioni | Q0BW57Primary (citable) accession number: Q0BW57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 28, 2018 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |