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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway:itetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 888ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGBET391165:GHON-47-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:GbCGDNIH1_0047
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
ProteomesiUP000001963 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Formate--tetrahydrofolate ligasePRO_0000293036Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0047.

Structurei

3D structure databases

ProteinModelPortaliQ0BW57.
SMRiQ0BW57. Positions 21-570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BW57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEANKPRG NQHQEAKSDA EIAQAAFMRP IVDVAAEKLG IAAEHLAPYG
60 70 80 90 100
HYKAKIDLNY LSSLDSRPDG KLVLVTAISP TPAGEGKTTT TVGLTDALNH
110 120 130 140 150
IGKKAVACLR EPSLGPCFGV KGGAAGGGYA QVVPMEDINL HFTGDFHAIG
160 170 180 190 200
AANNLLAALI DNHVYWGNEL GIDPRRIGWR RAVDMNDRAL RSIVSSLGGV
210 220 230 240 250
SNGYPREDGF DITVASEVMA IFCLATDLDD LQRRLGNIIV GHTKDRKPIR
260 270 280 290 300
ASELSAAGSM AVLLKDAIAP NLVQTLEHNP AFIHGGPFAN IAHGCNSVIA
310 320 330 340 350
TRAALKLSDY VVTEAGFGAD LGAEKFFDIK CRKAGLSPSA VVIVATVRAL
360 370 380 390 400
KMHGGVAKDA LKTENVEAVQ KGFANLERHI QNVRKFGVPV VVGVNKFSAD
410 420 430 440 450
TDAEFQMLHD LCAKMGVPCV SSDHWANGGA GAADLAHEVV KLVEGGSADF
460 470 480 490 500
KPLYPEDMPL WDKLRTIATE IYGASDITAD AAVRKRFDEL QKEGFGHLPI
510 520 530 540 550
CVAKTQYSFS TDANLRGAPS GHVIPVRDLR LSAGAEFVVA ICGDIMTMPG
560 570
LPKVPAANAI RLASNGTIAG LF
Length:572
Mass (Da):60,606
Last modified:October 17, 2006 - v1
Checksum:i6D804024DA30ADD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA. Translation: ABI60945.1.
RefSeqiWP_011630755.1. NC_008343.1.

Genome annotation databases

EnsemblBacteriaiABI60945; ABI60945; GbCGDNIH1_0047.
KEGGigbe:GbCGDNIH1_0047.
PATRICi22076091. VBIGraBet83793_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA. Translation: ABI60945.1.
RefSeqiWP_011630755.1. NC_008343.1.

3D structure databases

ProteinModelPortaliQ0BW57.
SMRiQ0BW57. Positions 21-570.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI60945; ABI60945; GbCGDNIH1_0047.
KEGGigbe:GbCGDNIH1_0047.
PATRICi22076091. VBIGraBet83793_0048.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciGBET391165:GHON-47-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
    Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
    J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1260 / CGDNIH1.

Entry informationi

Entry nameiFTHS_GRABC
AccessioniPrimary (citable) accession number: Q0BW57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 17, 2006
Last modified: July 22, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.