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Q0BW57 (FTHS_GRABC) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:GbCGDNIH1_0047
OrganismGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP]
Taxonomic identifier391165 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter ›

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293036

Regions

Nucleotide binding81 – 888ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0BW57 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 6D804024DA30ADD2

FASTA57260,606
        10         20         30         40         50         60 
MSTEANKPRG NQHQEAKSDA EIAQAAFMRP IVDVAAEKLG IAAEHLAPYG HYKAKIDLNY 

        70         80         90        100        110        120 
LSSLDSRPDG KLVLVTAISP TPAGEGKTTT TVGLTDALNH IGKKAVACLR EPSLGPCFGV 

       130        140        150        160        170        180 
KGGAAGGGYA QVVPMEDINL HFTGDFHAIG AANNLLAALI DNHVYWGNEL GIDPRRIGWR 

       190        200        210        220        230        240 
RAVDMNDRAL RSIVSSLGGV SNGYPREDGF DITVASEVMA IFCLATDLDD LQRRLGNIIV 

       250        260        270        280        290        300 
GHTKDRKPIR ASELSAAGSM AVLLKDAIAP NLVQTLEHNP AFIHGGPFAN IAHGCNSVIA 

       310        320        330        340        350        360 
TRAALKLSDY VVTEAGFGAD LGAEKFFDIK CRKAGLSPSA VVIVATVRAL KMHGGVAKDA 

       370        380        390        400        410        420 
LKTENVEAVQ KGFANLERHI QNVRKFGVPV VVGVNKFSAD TDAEFQMLHD LCAKMGVPCV 

       430        440        450        460        470        480 
SSDHWANGGA GAADLAHEVV KLVEGGSADF KPLYPEDMPL WDKLRTIATE IYGASDITAD 

       490        500        510        520        530        540 
AAVRKRFDEL QKEGFGHLPI CVAKTQYSFS TDANLRGAPS GHVIPVRDLR LSAGAEFVVA 

       550        560        570 
ICGDIMTMPG LPKVPAANAI RLASNGTIAG LF

« Hide

References

[1]"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1260 / CGDNIH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000394 Genomic DNA. Translation: ABI60945.1.
RefSeqYP_743868.1. NC_008343.1.

3D structure databases

ProteinModelPortalQ0BW57.
SMRQ0BW57. Positions 21-570.
ModBaseSearch...

Protein-protein interaction databases

STRING391165.GbCGDNIH1_0047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI60945; ABI60945; GbCGDNIH1_0047.
GeneID4274643.
KEGGgbe:GbCGDNIH1_0047.
PATRIC22076091. VBIGraBet83793_0048.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycGBET391165:GHON-47-MONOMER.
UniPathwayUPA00193.

Family and domain databases

HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_GRABC
AccessionPrimary (citable) accession number: Q0BW57
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 17, 2006
Last modified: November 13, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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