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Q0BW57

- FTHS_GRABC

UniProt

Q0BW57 - FTHS_GRABC

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi81 – 888ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGBET391165:GHON-47-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:GbCGDNIH1_0047
    OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
    Taxonomic identifieri391165 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
    ProteomesiUP000001963: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Formate--tetrahydrofolate ligasePRO_0000293036Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391165.GbCGDNIH1_0047.

    Structurei

    3D structure databases

    ProteinModelPortaliQ0BW57.
    SMRiQ0BW57. Positions 21-570.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q0BW57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTEANKPRG NQHQEAKSDA EIAQAAFMRP IVDVAAEKLG IAAEHLAPYG    50
    HYKAKIDLNY LSSLDSRPDG KLVLVTAISP TPAGEGKTTT TVGLTDALNH 100
    IGKKAVACLR EPSLGPCFGV KGGAAGGGYA QVVPMEDINL HFTGDFHAIG 150
    AANNLLAALI DNHVYWGNEL GIDPRRIGWR RAVDMNDRAL RSIVSSLGGV 200
    SNGYPREDGF DITVASEVMA IFCLATDLDD LQRRLGNIIV GHTKDRKPIR 250
    ASELSAAGSM AVLLKDAIAP NLVQTLEHNP AFIHGGPFAN IAHGCNSVIA 300
    TRAALKLSDY VVTEAGFGAD LGAEKFFDIK CRKAGLSPSA VVIVATVRAL 350
    KMHGGVAKDA LKTENVEAVQ KGFANLERHI QNVRKFGVPV VVGVNKFSAD 400
    TDAEFQMLHD LCAKMGVPCV SSDHWANGGA GAADLAHEVV KLVEGGSADF 450
    KPLYPEDMPL WDKLRTIATE IYGASDITAD AAVRKRFDEL QKEGFGHLPI 500
    CVAKTQYSFS TDANLRGAPS GHVIPVRDLR LSAGAEFVVA ICGDIMTMPG 550
    LPKVPAANAI RLASNGTIAG LF 572
    Length:572
    Mass (Da):60,606
    Last modified:October 17, 2006 - v1
    Checksum:i6D804024DA30ADD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000394 Genomic DNA. Translation: ABI60945.1.
    RefSeqiYP_743868.1. NC_008343.1.

    Genome annotation databases

    EnsemblBacteriaiABI60945; ABI60945; GbCGDNIH1_0047.
    GeneIDi4274643.
    KEGGigbe:GbCGDNIH1_0047.
    PATRICi22076091. VBIGraBet83793_0048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000394 Genomic DNA. Translation: ABI60945.1 .
    RefSeqi YP_743868.1. NC_008343.1.

    3D structure databases

    ProteinModelPortali Q0BW57.
    SMRi Q0BW57. Positions 21-570.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391165.GbCGDNIH1_0047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI60945 ; ABI60945 ; GbCGDNIH1_0047 .
    GeneIDi 4274643.
    KEGGi gbe:GbCGDNIH1_0047.
    PATRICi 22076091. VBIGraBet83793_0048.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci GBET391165:GHON-47-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
      Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
      J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1260 / CGDNIH1.

    Entry informationi

    Entry nameiFTHS_GRABC
    AccessioniPrimary (citable) accession number: Q0BW57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3