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Q0BW57

- FTHS_GRABC

UniProt

Q0BW57 - FTHS_GRABC

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, GbCGDNIH1_0047
Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 888ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGBET391165:GHON-47-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:GbCGDNIH1_0047
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
ProteomesiUP000001963: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000293036Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0047.

Structurei

3D structure databases

ProteinModelPortaliQ0BW57.
SMRiQ0BW57. Positions 21-570.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BW57-1 [UniParc]FASTAAdd to Basket

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MSTEANKPRG NQHQEAKSDA EIAQAAFMRP IVDVAAEKLG IAAEHLAPYG    50
HYKAKIDLNY LSSLDSRPDG KLVLVTAISP TPAGEGKTTT TVGLTDALNH 100
IGKKAVACLR EPSLGPCFGV KGGAAGGGYA QVVPMEDINL HFTGDFHAIG 150
AANNLLAALI DNHVYWGNEL GIDPRRIGWR RAVDMNDRAL RSIVSSLGGV 200
SNGYPREDGF DITVASEVMA IFCLATDLDD LQRRLGNIIV GHTKDRKPIR 250
ASELSAAGSM AVLLKDAIAP NLVQTLEHNP AFIHGGPFAN IAHGCNSVIA 300
TRAALKLSDY VVTEAGFGAD LGAEKFFDIK CRKAGLSPSA VVIVATVRAL 350
KMHGGVAKDA LKTENVEAVQ KGFANLERHI QNVRKFGVPV VVGVNKFSAD 400
TDAEFQMLHD LCAKMGVPCV SSDHWANGGA GAADLAHEVV KLVEGGSADF 450
KPLYPEDMPL WDKLRTIATE IYGASDITAD AAVRKRFDEL QKEGFGHLPI 500
CVAKTQYSFS TDANLRGAPS GHVIPVRDLR LSAGAEFVVA ICGDIMTMPG 550
LPKVPAANAI RLASNGTIAG LF 572
Length:572
Mass (Da):60,606
Last modified:October 17, 2006 - v1
Checksum:i6D804024DA30ADD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI60945.1.
RefSeqiYP_743868.1. NC_008343.1.

Genome annotation databases

EnsemblBacteriaiABI60945; ABI60945; GbCGDNIH1_0047.
GeneIDi4274643.
KEGGigbe:GbCGDNIH1_0047.
PATRICi22076091. VBIGraBet83793_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000394 Genomic DNA. Translation: ABI60945.1 .
RefSeqi YP_743868.1. NC_008343.1.

3D structure databases

ProteinModelPortali Q0BW57.
SMRi Q0BW57. Positions 21-570.
ModBasei Search...

Protein-protein interaction databases

STRINGi 391165.GbCGDNIH1_0047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI60945 ; ABI60945 ; GbCGDNIH1_0047 .
GeneIDi 4274643.
KEGGi gbe:GbCGDNIH1_0047.
PATRICi 22076091. VBIGraBet83793_0048.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci GBET391165:GHON-47-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
    Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
    J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1260 / CGDNIH1.

Entry informationi

Entry nameiFTHS_GRABC
AccessioniPrimary (citable) accession number: Q0BW57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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