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Q0BVN3 (Q0BVN3_GRABC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase 1 HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 1 HAMAP MF_00315
Gene names
Name:dxs1 HAMAP MF_00315
Ordered Locus Names:GbCGDNIH1_0221
OrganismGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP] EMBL ABI61119.1
Taxonomic identifier391165 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter

Protein attributes

Sequence length674 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
Q0BVN3 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 438A5A58C346A53E

FASTA67472,073
        10         20         30         40         50         60 
MSETDFMTET TPVRCHETPT LDRVRYPSDL RNMSSEQLRA VADELRAETV DAVSVTGGHL 

        70         80         90        100        110        120 
GAALGVIELT VAIHAVFDTP SDRLIWDVGH QAYPHKILTG RRDRIRTLRM GGGLSGFTKR 

       130        140        150        160        170        180 
SESEYDPFGA GHSSTSISAG LGMAVARDLR RAAGEVGAGP EHVIAVIGDG AMSAGMVYEA 

       190        200        210        220        230        240 
MNNAGSLKSR LVVILNDNDM SIAPPVGAMS AYLSRLLSSR SFLNLRDLAG KMARHFPRGI 

       250        260        270        280        290        300 
ERTARRAEEY ARGILTGGTL FEELGFYYVG PIDGHNLDHL LPVLRNVRDA EETGPILVHA 

       310        320        330        340        350        360 
ITRKGHGYAP AEASADKYHA VSRFNVVTGE QIKPAPVPGA KPAPPTYTKV FAEALIAAAE 

       370        380        390        400        410        420 
ENPRVVAINA AMPSGTGLDA FEKRFPDRCF DVGIAEQHAV TFAAGLAVEG MVPFCALYST 

       430        440        450        460        470        480 
FLQRGYDQLV HDVAIQHLPV RFAIDRAGLV GADGATHAGS FDMAYLGCLP GMMIMSPSDE 

       490        500        510        520        530        540 
AELVHAVATV AAYDSGPSAV RYPRGEGVGV ALPRDEKGRL RGDVLPIGRG RIVREGRSGI 

       550        560        570        580        590        600 
AILSIGTRLQ DALLAADDLA AHGLTVTVAD GRFVKPLDTA LVERLAREND VLVVVEEGSI 

       610        620        630        640        650        660 
GGYASHVMQH LAQAGLLDAR DGHALKLRSM ILPDRYIDHD TQPNQIRQAG LDHQAIRDTV 

       670 
LKLVDVGVTA AQPA

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References

[1]"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
J. Bacteriol. 189:8727-8736(2007) [PubMed: 17827295] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000394 Genomic DNA. Translation: ABI61119.1.
RefSeqYP_744042.1. NC_008343.1.

3D structure databases

ProteinModelPortalQ0BVN3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0BVN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4274630.
GenomeReviewsGene locus GbCGDNIH1_0221 in contig CP000394_GR.
KEGGgbe:GbCGDNIH1_0221.
NMPDRfig|391165.8.peg.223.
PATRIC22076463. VBIGraBet83793_0230.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAEAMNAHA.
PhylomeDBQ0BVN3.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ0BVN3_GRABC
AccessionPrimary (citable) accession number: Q0BVN3
Entry history
Integrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info