Q0BVI9 (Q0BVI9_GRABC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	GbCGDNIH1_0265

Organism

Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP] EMBL ABI61163.1

Taxonomic identifier

391165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ABI61163.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	514	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	606	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q0BVI9 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 8CABC9CEF0DBD6A2	FASTA	644	70,805
	10 20 30 40 50 60 MSEPTLIHVK PSLADSAHVN ARRHSLMTHQ AGTDPDAFWA EEARRIPWFR EPTLIKSTSF 70 80 90 100 110 120 EGDVSIRWFE DGRLNASVAC LDQHLETRGD QSAILWEGDE PGTQGSLTYR QLHDRVCRLA 130 140 150 160 170 180 NVMKSMGIGR GDRVTIYLPM VIEAAIAMLA CARIGAVHAV VFGGFSPDSL ADRIRDSESS 190 200 210 220 230 240 LLITADEGRR GGRKVPLKRN ADEALSRVDC IRNVIVVTVT GGDVNMQAGR DQRYETLIEA 250 260 270 280 290 300 ASPDCPPEEM NAEDPLFILY TSGSTGTPKG VLHTTGGYMV WASFTHELVF DYHAPEVYWC 310 320 330 340 350 360 TADVGWITGH TYIVYGPLAN GATTLMFEGV PNYPDSSRFW QVVDKYNVSI FYTAPTAIRA 370 380 390 400 410 420 LMREGDAPVK KTSRKSLRIL GTVGEPINPE AWRWYYEVVG EERCPVIDTW WQTETGGHLI 430 440 450 460 470 480 TPLPGAIAQK PGSATLPLPG VKAVLVDNEG NVLEGEAEGS LCIADSWPGQ MRTLYGDHER 490 500 510 520 530 540 FVQTYFSTYK GLYFTGDGAR RDADGYFWIT GRIDDVLNVS GHRLGTAEVE SALVAHGDVA 550 560 570 580 590 600 EAAVVGVPHD IKGQGIYAFV TLKDGYEPSD TLRSELINWV RRQIGPIATP DVIQWAPGLP 610 620 630 640 KTRSGKIMRR ILRKIACNET DGLGDISTLA DPSVVEDLIA NRPA

References

[1]

"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis." Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M. J. Bacteriol. 189:8727-8736(2007) [PubMed: 17827295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000394 Genomic DNA. Translation: ABI61163.1.
RefSeq	YP_744086.1. NC_008343.1.
3D structure databases
ProteinModelPortal	Q0BVI9.
SMR	Q0BVI9. Positions 8-644.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0BVI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4274484.
GenomeReviews	Gene locus GbCGDNIH1_0265 in contig CP000394_GR.
KEGG	gbe:GbCGDNIH1_0265.
NMPDR	fig|391165.8.peg.268.
PATRIC	22076557. VBIGraBet83793_0276.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	EMEGECS.
PhylomeDB	Q0BVI9.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0BVI9_GRABC

Accession

Primary (citable) accession number: Q0BVI9

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)