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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.IEP:

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.IEP:

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.IEP:
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseIEP: (EC:2.7.8.13IEP:)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseIEP:
Gene namesi
Name:mraYIEP:
Ordered Locus Names:GbCGDNIH1_0432
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
Proteomesi
  • UP000001963 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalIEP:Add BLAST21
Transmembranei72 – 92HelicalIEP:Add BLAST21
Transmembranei100 – 120HelicalIEP:Add BLAST21
Transmembranei134 – 154HelicalIEP:Add BLAST21
Transmembranei170 – 190HelicalIEP:Add BLAST21
Transmembranei201 – 221HelicalIEP:Add BLAST21
Transmembranei241 – 261HelicalIEP:Add BLAST21
Transmembranei265 – 285HelicalIEP:Add BLAST21
Transmembranei290 – 310HelicalIEP:Add BLAST21
Transmembranei339 – 359HelicalIEP:Add BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003325361 – 362Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST362

Interactioni

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0432.

Structurei

3D structure databases

SMRiQ0BV22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.IEP:

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0BV22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYDLAHPLA EQFFLFNLFR YITFRSGAAC MTALIVSFLL GPALIRWLKS
60 70 80 90 100
VQRGGQPIRE DGPERHLLEK KGTPTMGGVL ILAATGISTL LWTDLRNGYV
110 120 130 140 150
WAVLLLTLGY GGIGFADDYL KLSKRNTKGL PGRVKLIGQA VIGLIAAIWI
160 170 180 190 200
MSLTRDPLST GLAIPLLKDV LIPLGFAFPL FGMLVAMGAS NAVNLTDGLD
210 220 230 240 250
GLAIVPTIIA AGVFALIAYL VGNHVFATYL QLNEVAGTGE LTVFCSALIG
260 270 280 290 300
AGLGFLWFNA PPARVFMGDT GSLALGGALG GVAIATKHEI VLAIVGGLFV
310 320 330 340 350
VETISVIVQV FWYKRTGRRV FLMAPLHHHF EKKGWPESTI VIRFWIVSFI
360
LALAGLATLK IR
Length:362
Mass (Da):38,973
Last modified:October 17, 2006 - v1
Checksum:i5A2F15115EF9F69C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA. Translation: ABI61330.1.

Genome annotation databases

EnsemblBacteriaiABI61330; ABI61330; GbCGDNIH1_0432.
KEGGigbe:GbCGDNIH1_0432.

Similar proteinsi

Entry informationi

Entry nameiMRAY_GRABC
AccessioniPrimary (citable) accession number: Q0BV22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 17, 2006
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families