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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciGBET391165:GHON-619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1UniRule annotation
Short name:
RF-1UniRule annotation
Gene namesi
Name:prfAUniRule annotation
Ordered Locus Names:GbCGDNIH1_0606
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
ProteomesiUP000001963 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Peptide chain release factor 1PRO_0000263281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291N5-methylglutamineUniRule annotation

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1.UniRule annotation

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0606.

Structurei

3D structure databases

ProteinModelPortaliQ0BUJ8.
SMRiQ0BUJ8. Positions 89-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prokaryotic/mitochondrial release factor family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0216.
HOGENOMiHOG000074815.
KOiK02835.
OMAiWKVEIVS.
OrthoDBiEOG6TN48J.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q0BUJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFTANLDRI VARAEELRAS LSEGLNGDSF AAASRELAEL EPVVARIEEL
60 70 80 90 100
WAAERGLAEA EAMLADPDMR ELAESEAEIL REKLPSLTRE IRIALLPKDE
110 120 130 140 150
ADERSAILEI RPAAGGDEAS LFAAQLFSMY QRYAEIRGWR FEILEYDDTG
160 170 180 190 200
LGGLKGGMAE ITGRSVFARL KYESGVHRVQ RVPATESQGR IHTSTVTVAV
210 220 230 240 250
LPEAEDVDVQ VDEGDLRIDV YRASGAGGQH VNKTESAVRI THLPSGIVVA
260 270 280 290 300
MQEEKSQHKN RAKAMKILKA RLYEQQRAAL HASRAADRRA QVGTGDRSER
310 320 330 340 350
IRTYNFPQGR VSDHRINLTL YKIDRVMLGE LDDFVDALTA EDQAARLSAQ

EL
Length:352
Mass (Da):39,011
Last modified:October 17, 2006 - v1
Checksum:iA3816F05C06376CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA. Translation: ABI61504.1.
RefSeqiWP_011631313.1. NC_008343.1.
YP_744427.1. NC_008343.1.

Genome annotation databases

EnsemblBacteriaiABI61504; ABI61504; GbCGDNIH1_0606.
KEGGigbe:GbCGDNIH1_0606.
PATRICi22077289. VBIGraBet83793_0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA. Translation: ABI61504.1.
RefSeqiWP_011631313.1. NC_008343.1.
YP_744427.1. NC_008343.1.

3D structure databases

ProteinModelPortaliQ0BUJ8.
SMRiQ0BUJ8. Positions 89-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI61504; ABI61504; GbCGDNIH1_0606.
KEGGigbe:GbCGDNIH1_0606.
PATRICi22077289. VBIGraBet83793_0635.

Phylogenomic databases

eggNOGiCOG0216.
HOGENOMiHOG000074815.
KOiK02835.
OMAiWKVEIVS.
OrthoDBiEOG6TN48J.

Enzyme and pathway databases

BioCyciGBET391165:GHON-619-MONOMER.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
HAMAPiMF_00093. Rel_fac_1.
InterProiIPR014720. dsRNA-bd_dom.
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
[Graphical view]
PfamiPF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
[Graphical view]
SMARTiSM00937. PCRF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiPS00745. RF_PROK_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
    Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
    J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1260 / CGDNIH1.

Entry informationi

Entry nameiRF1_GRABC
AccessioniPrimary (citable) accession number: Q0BUJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 17, 2006
Last modified: April 29, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.