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Protein

Pantothenate synthetase

Gene

panC

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei153PantoateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi147 – 150ATPUniRule annotation4
Nucleotide bindingi184 – 187ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGBET391165:G1G6T-781-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:GbCGDNIH1_0758
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
Proteomesi
  • UP000001963 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003054601 – 287Pantothenate synthetaseAdd BLAST287

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_0758

Structurei

3D structure databases

ProteinModelPortaliQ0BU46
SMRiQ0BU46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R03 Bacteria
COG0414 LUCA
HOGENOMiHOG000175516
KOiK01918
OMAiQITKPDN
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BU46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLARTLPTL QQAVHQLRHA GKRIAFVPTM GALHEGHQSL VRAAIAQDYA
60 70 80 90 100
VVTSVFVNPT QFGPSEDLAR YPRDEKGDIA ILERTGCSIA WLPDVDTMYP
110 120 130 140 150
PGDATGFVMG GPALGWEGAR RPGHFNGVAQ VVAKLFGQVR PDAAFFGEKD
160 170 180 190 200
WQQLQVIRRL TADLLLPVAI HGVPTQREED GLAMSSRNRF LSPEERAIAP
210 220 230 240 250
LLFRTLLQAG HALSSSPDAE EICKNAIAAL NGQGFDVDYF ALIEGSSLSS
260 270 280
IAILPEGDDW RLITAARLGS VRLLDNLGRA ELARFRA
Length:287
Mass (Da):31,223
Last modified:October 17, 2006 - v1
Checksum:i5B3A527D8F502364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA Translation: ABI61656.1
RefSeqiWP_011631465.1, NC_008343.2

Genome annotation databases

EnsemblBacteriaiABI61656; ABI61656; GbCGDNIH1_0758
GeneIDi31475464
KEGGigbe:GbCGDNIH1_0758

Similar proteinsi

Entry informationi

Entry nameiPANC_GRABC
AccessioniPrimary (citable) accession number: Q0BU46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health