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Q0BTT3 (UPPP_GRABC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:GbCGDNIH1_0871
OrganismGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP]
Taxonomic identifier391165 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290713

Regions

Transmembrane12 – 3423Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane95 – 11521Helical; Potential
Transmembrane120 – 14021Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane272 – 29221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0BTT3 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: B1852C0BBE0298E7

FASTA29531,743
        10         20         30         40         50         60 
MRIESMNAIQ AIAIAILQGA TELFPVSSLG HAVVLPALLG WSLPQHSQTF LPFLVFLHLG 

        70         80         90        100        110        120 
TAAALLLYFW RDWWALFSGV IGFAPAHHVP QARRIFMLLV VATLPAIVVG GLLEHMLRAL 

       130        140        150        160        170        180 
FESAPIAAFF LVVNGGLLLF GEKLRGAASP YPQTSDHEVT ERRALSTLTV MDAFTIGCWQ 

       190        200        210        220        230        240 
CAALIPGISR SGATIVGGLL RGIDHEASAH FSFLIALPII LGATVLEVPK LLHADIAPGV 

       250        260        270        280        290 
FQTAALAAVA AGITAWLSTA FLMRYFRDHD SWALKPFAFY CIIAGLGALA WLHFA 

« Hide

References

[1]"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis."
Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.
J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1260 / CGDNIH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000394 Genomic DNA. Translation: ABI61769.1.
RefSeqYP_744692.1. NC_008343.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391165.GbCGDNIH1_0871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI61769; ABI61769; GbCGDNIH1_0871.
GeneID4275685.
KEGGgbe:GbCGDNIH1_0871.
PATRIC22077855. VBIGraBet83793_0909.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMADHEASAH.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycGBET391165:GHON-893-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_GRABC
AccessionPrimary (citable) accession number: Q0BTT3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families