Q0BTL0 (Q0BTL0_GRABC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387

Gene names

Name:	lpxA HAMAP MF_00387
Ordered Locus Names:	GbCGDNIH1_0944

Organism

Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP] EMBL ABI61842.1

Taxonomic identifier

391165 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00387 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00387
Domain	Repeat HAMAP MF_00387
Molecular function	Acyltransferase HAMAP MF_00387 EMBL ABI61842.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0BTL0 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: DA53FB17750454B3	FASTA	283	30,123
	10 20 30 40 50 60 MMNPVTELKP ATIHPTAIIS PSAKIGAGVS IGPFCAVGPD VELSDGVTLV SHVVVDGHTV 70 80 90 100 110 120 IGEGATLWPF CSVGLAPQDL KYRGEPTRTE IGARTQIREH CTIHRGTVTG TGLTKVGSDC 130 140 150 160 170 180 LLMAVAHVAH DCEVGNNVII ANNVVMGGHV TIGDHAGIMG AAAIHQFVRI GRCAWVGGVS 190 200 210 220 230 240 GVERDVIPFG MVMGNRAWLA GLNIVGLKRR GYDRSEIHRL RAAFRILYRD TSVDDGVFQE 250 260 270 280 RVQRVAAEYG EDRLIAEMLA FIAAPSHRGL IRNGVRDDGA EPA

References

[1]

"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis." Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M. J. Bacteriol. 189:8727-8736(2007) [PubMed: 17827295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000394 Genomic DNA. Translation: ABI61842.1.
RefSeq	YP_744765.1. NC_008343.1.
3D structure databases
ProteinModelPortal	Q0BTL0.
SMR	Q0BTL0. Positions 9-272.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0BTL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4274519.
GenomeReviews	Gene locus GbCGDNIH1_0944 in contig CP000394_GR.
KEGG	gbe:GbCGDNIH1_0944.
NMPDR	fig|391165.8.peg.950.
PATRIC	22078021. VBIGraBet83793_0988.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1043.
HOGENOM	HBG659295.
OMA	REFCTFN.
PhylomeDB	Q0BTL0.
ProtClustDB	PRK05289.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 4 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q0BTL0_GRABC

Accession

Primary (citable) accession number: Q0BTL0

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)