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Protein

dCTP deaminase

Gene

dcd

Organism
Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Proton donor/acceptorUniRule annotation1
Binding sitei152dCTPUniRule annotation1
Binding sitei166dCTPUniRule annotation1
Binding sitei176dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 112dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:GbCGDNIH1_1038
OrganismiGranulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)
Taxonomic identifieri391165 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGranulibacter
Proteomesi
  • UP000001963 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000097311 – 184dCTP deaminaseAdd BLAST184

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi391165.GbCGDNIH1_1038

Structurei

3D structure databases

ProteinModelPortaliQ0BTB7
SMRiQ0BTB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228600
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H02A6

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q0BTB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIMPDHWIR QMATGHGMIE PFVETQKRDG VISYGLSSYG YDARVADEFK
60 70 80 90 100
IFTNVDSAVV DPKAFSPASF VDRKGPVCII PPNSFALAHT VEYFRIPRNV
110 120 130 140 150
LVICLGKSTY ARCGIIVNVT PLEPEWEGQV TIEISNTTPL PARIYAGEGI
160 170 180
CQFLFLRGDS DCETSYADKA GKYMGQRGVS LPRM
Length:184
Mass (Da):20,391
Last modified:October 17, 2006 - v1
Checksum:iE6135AFD7F21BDB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000394 Genomic DNA Translation: ABI61936.1
RefSeqiWP_011631744.1, NC_008343.2

Genome annotation databases

EnsemblBacteriaiABI61936; ABI61936; GbCGDNIH1_1038
GeneIDi31475742
KEGGigbe:GbCGDNIH1_1038

Similar proteinsi

Entry informationi

Entry nameiDCD_GRABC
AccessioniPrimary (citable) accession number: Q0BTB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health