Q0BSW7 (Q0BSW7_GRABC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydrolipoyl dehydrogenase RuleBase RU003692
EC=1.8.1.4 RuleBase RU003692

Gene names

Ordered Locus Names:

GbCGDNIH1_1187

Organism

Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) [Complete proteome] [HAMAP] EMBL ABI62085.1

Taxonomic identifier

391165 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Granulibacter › Granulibacter bethesdensis

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH. RuleBase RU003692
Cofactor	Binds 1 FAD per subunit By similarity. RuleBase RU003692
Miscellaneous	The active site is a redox-active disulfide bond By similarity. RuleBase RU003692
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003691

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003691
Ligand	FAD RuleBase RU003691 Flavoprotein RuleBase RU003691 NAD RuleBase RU003692
Molecular function	Oxidoreductase RuleBase RU003691 EMBL ABI62085.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	dihydrolipoyl dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q0BSW7 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: DD4ABD39E25C9EBA	FASTA	465	49,628
	10 20 30 40 50 60 MADTVFDLIV VGGGPGGYVA AIRAAQLGMK TALVERAHLG GICLNWGCIP TKALLRAAEI 70 80 90 100 110 120 NHLLHHLSDF GFAADNIRYD LDAVVKRSRT VAGQLSSGVK HLLKKNKVTV FDGHARLSGR 130 140 150 160 170 180 HRLDVSKDGQ PVATLEAPHI VLATGARARQ LPGLEADGTL IWSYREAMVP KALPKRLLVV 190 200 210 220 230 240 GSGAIGIEFA SFYRSLGSEV TVLEAVERIL PAEDEEIAAF ARKSFEAQGM TIHTGVKIGK 250 260 270 280 290 300 VEKGRDEVTI SFEAAGKKHS LTVDRIIAAV GIVGNVENLG LEGTAVTIEK THIVTDGLGR 310 320 330 340 350 360 TGEDGVYAIG DLTGPPWLAH KASHEAVLCV EAIAGLDVHP LDITNIPGCT YCRPQIASVG 370 380 390 400 410 420 LTEAKARERG YEVRVGRFPF IGNGKAIAMG EAEGLTKTIF DAKTGELLGA HMVGPEVTEM 430 440 450 460 IQGFTIARTL ETTEAELMHT VFPHPTVSET MHEAVLDAYG RALHF

References

[1]

"Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis." Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E., Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M. J. Bacteriol. 189:8727-8736(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1260 / CGDNIH1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000394 Genomic DNA. Translation: ABI62085.1.
RefSeq	YP_745008.1. NC_008343.1.
3D structure databases
ProteinModelPortal	Q0BSW7.
ModBase	Search...
Protein-protein interaction databases
STRING	391165.GbCGDNIH1_1187.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABI62085; ABI62085; GbCGDNIH1_1187.
GeneID	4274678.
KEGG	gbe:GbCGDNIH1_1187.
PATRIC	22078533. VBIGraBet83793_1236.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1249.
HOGENOM	HOG000276708.
KO	K00382.
OMA	CTPQVAS.
Enzyme and pathway databases
BioCyc	GBET391165:GHON-1248-MONOMER.
Family and domain databases
Gene3D	3.30.390.30. 1 hit.
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR006258. Lipoamide_DH. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR012999. Pyr_OxRdtase_I_AS. IPR001327. Pyr_OxRdtase_NAD-bd_dom. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMs	TIGR01350. lipoamide_DH. 1 hit.
PROSITE	PS00076. PYRIDINE_REDOX_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q0BSW7_GRABC

Accession

Primary (citable) accession number: Q0BSW7

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)